Comparative analysis reveals a role for TGF-β in shaping the residency-related transcriptional signature in tissue-resident memory CD8+ T cells

• Published in: PloS one Vol. 14; no. 2; p. e0210495
• Main Authors: Nath, Artika P, Braun, Asolina, Ritchie, Scott C, Carbone, Francis R, Mackay, Laura K, Gebhardt, Thomas, Inouye, Michael
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.02.2019; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cells, Cultured; Comparative analysis; Cytokines; Diabetes; Female; Flow cytometry; Gene Expression Regulation; Gene set enrichment analysis; Genomes; Genomic imprinting; Genomics; Growth factors; Immune system; Immunologic Memory; Immunological memory; Immunology; Imprinting; Infections; Lymphocytes; Lymphocytes T; Medicine and Health Sciences; Memory cells; Mice, Inbred C57BL; Primary care; Public health; Research and Analysis Methods; Ribonucleic acid; RNA; Signaling; Signatures; T cell receptors; Tissues; Transcription; Transcriptome; Transforming growth factor; Transforming Growth Factor beta - immunology; Transforming growth factor-b; United Kingdom > UK; Australia; Victoria Australia

Tissue-resident CD8+ memory T (TRM) cells are immune cells that permanently reside at tissue sites where they play an important role in providing rapid protection against reinfection. They are not only phenotypically and functionally distinct from their circulating memory counterparts, but also exhi...