The Role of Hemosiderin Excision in Seizure Outcome in Cerebral Cavernous Malformation Surgery: A Systematic Review and Meta-Analysis

• Published in: PloS one Vol. 10; no. 8; p. e0136619
• Main Authors: Ruan, Di, Yu, Xiao-Bo, Shrestha, Sudeep, Wang, Lin, Chen, Gao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.08.2015; Public Library of Science (PLoS)
• Subjects: Asia; Cohort analysis; Epilepsy; Epilepsy - metabolism; Epilepsy - physiopathology; Epilepsy - surgery; Hemangioma, Cavernous, Central Nervous System - metabolism; Hemangioma, Cavernous, Central Nervous System - physiopathology; Hemangioma, Cavernous, Central Nervous System - surgery; Hemosiderin - metabolism; Humans; Lesions; Literature reviews; Medical ethics; Medicine; Meta-analysis; Nervous system; Neurosurgery; Patients; Quality; Retrospective Studies; Seizing; Seizures - metabolism; Seizures - physiopathology; Seizures - surgery; Sensitivity analysis; Studies; Subgroups; Surgery; Surgical outcomes; Systematic review; Treatment Outcome; Asia; China

Whether the excision of hemosiderin surrounding cerebral cavernous malformations (CCMs) is necessary to achieve a seizure-free result has been the subject of debate. Here, we report a systematic review of related literature up to Jan 1, 2015 including 594 patients to assess the effect of hemosiderin...