Respiratory Syncytial Virus Increases the Virulence of Streptococcus pneumoniae by Binding to Penicillin Binding Protein 1a. A New Paradigm in Respiratory Infection

• Published in: American journal of respiratory and critical care medicine Vol. 190; no. 2; pp. 196 - 207
• Main Authors: Smith, Claire M., Sandrini, Sara, Datta, Sumit, Freestone, Primrose, Shafeeq, Sulman, Radhakrishnan, Priya, Williams, Gwyneth, Glenn, Sarah M., Kuipers, Oscar P., Hirst, Robert A., Easton, Andrew J., Andrew, Peter W., O’Callaghan, Christopher
• Format: Journal Article
• Language: English
• Published: New York, NY American Thoracic Society 15.07.2014
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Antibodies; Bacteria; Bacterial Adhesion; Bacterial diseases; Biological and medical sciences; Biomarkers - metabolism; Blotting, Western; Cell culture; Cells, Cultured; Coinfection - metabolism; Coinfection - microbiology; Epithelial Cells - metabolism; Epithelial Cells - microbiology; Female; Gene expression; Gene Expression Regulation, Bacterial; Human bacterial diseases; Human viral diseases; Humans; Infectious diseases; Intensive care medicine; Medical sciences; Mice; Microscopy; Microscopy, Confocal; Original; Pathogens; Penicillin; Penicillin-Binding Proteins - metabolism; Pneumology; Pneumonia; Pneumonia, Pneumococcal - metabolism; Pneumonia, Pneumococcal - microbiology; Pneumonia, Pneumococcal - virology; Proteins; Real-Time Polymerase Chain Reaction; Respiratory diseases; Respiratory Mucosa - metabolism; Respiratory Mucosa - microbiology; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - metabolism; Respiratory Syncytial Virus Infections - microbiology; Respiratory Syncytial Viruses - metabolism; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus infections; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - metabolism; Streptococcus pneumoniae - pathogenicity; Streptococcus pneumoniae - virology; Transcriptome; Up-Regulation; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Viral Fusion Proteins - metabolism; Virulence; United Kingdom > UK; Denmark; Human respiratory syncytial virus; Intensive care; Paradigm; Virulence; Respiratory system; Paramyxoviridae; Penicillin binding protein; Respiratory tract; Binding protein; pneumococcus; Streptococcal infection; Bacteria; Micrococcales; Pneumovirus; Pneumococcal infection; Resuscitation; Cilia; G protein; Pneumovirinae; Respiratory disease; Increase; Streptococcus pneumoniae; Virus; Infection; Streptococcaceae; Mononegavirales; Bacteriosis; respiratory syncytial virus; cilia; virulence

Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major respiratory pathogens. Coinfection with RSV and S. pneumoniae is associated with severe and often fatal pneumonia but the molecular basis for this remains unclear. To determine if interaction between RSV and pneumococci enhance...