Respiratory Syncytial Virus Increases the Virulence of Streptococcus pneumoniae by Binding to Penicillin Binding Protein 1a. A New Paradigm in Respiratory Infection - Smith, Claire M.; Sandrini, Sara; Datta, Sumit; Freestone, Primrose; Shafeeq, Sulman; Radhakrishnan, Priya; Williams, Gwyneth; Glenn, Sarah M.; Kuipers, Oscar P.; Hirst, Robert A.; Easton, Andrew J.; Andrew, Peter W.; et al. (American journal of respiratory and critical care medicine, 2014)
Keywords: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Antibodies; Bacteria; Bacterial Adhesion; Bacterial diseases; Biological and medical sciences; Biomarkers - metabolism; Blotting, Western; Cell culture; Cells, Cultured; Coinfection - metabolism; Coinfection - microbiology; Epithelial Cells - metabolism; Epithelial Cells - microbiology; Female; Gene expression; Gene Expression Regulation, Bacterial; Human bacterial diseases; Human viral diseases; Humans; Infectious diseases; Intensive care medicine; Medical sciences; Mice; Microscopy; Microscopy, Confocal; Original; Pathogens; Penicillin; Penicillin-Binding Proteins - metabolism; Pneumology; Pneumonia; Pneumonia, Pneumococcal - metabolism; Pneumonia, Pneumococcal - microbiology; Pneumonia, Pneumococcal - virology; Proteins; Real-Time Polymerase Chain Reaction; Respiratory diseases; Respiratory Mucosa - metabolism; Respiratory Mucosa - microbiology; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - metabolism; Respiratory Syncytial Virus Infections - microbiology; Respiratory Syncytial Viruses - metabolism; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus infections; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - metabolism; Streptococcus pneumoniae - pathogenicity; Streptococcus pneumoniae - virology; Transcriptome; Up-Regulation; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Viral Fusion Proteins - metabolism; Virulence; United Kingdom--UK; Denmark; Human respiratory syncytial virus; Intensive care; Paradigm; Virulence; Respiratory system; Paramyxoviridae; Penicillin binding protein; Respiratory tract; Binding protein; pneumococcus; Streptococcal infection; Bacteria; Micrococcales; Pneumovirus; Pneumococcal infection; Resuscitation; Cilia; G protein; Pneumovirinae; Respiratory disease; Increase; Streptococcus pneumoniae; Virus; Infection; Streptococcaceae; Mononegavirales; Bacteriosis; respiratory syncytial virus; cilia; virulence