Noninvasive predictors of nonalcoholic steatohepatitis in Korean patients with histologically proven nonalcoholic fatty liver disease
The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severi...
Saved in:
| Published in | Clinical and molecular hepatology Vol. 19; no. 2; pp. 120 - 130 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Association for the Study of the Liver
01.06.2013
The Korean Association for the Study of the Liver 대한간학회 |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH.
One hundred and eight consecutive patients with biopsy-proven NAFLD (age, 39.8±13.5 years, mean±SD; males, 67.6%) were prospectively enrolled from 10 participating centers across Korea.
According to the original criteria for NAFLD subtypes, 67 patients (62.0%) had NASH (defined as steatosis with hepatocellular ballooning and/or Mallory-Denk bodies or fibrosis ≥2). Among those with NAFLD subtype 3 or 4, none had an NAFLD histologic activity score (NAS) below 3 points, 40.3% had a score of 3 or 4 points, and 59.7% had a score >4 points. Fragmented cytokeratin-18 (CK-18) levels were positively correlated with NAS (r=0.401), as well as NAS components such as lobular inflammation (r=0.387) and ballooning (r=0.231). Fragmented CK-18 was also correlated with aspartate aminotransferase (r=0.609), alanine aminotransferase (r=0.588), serum ferritin (r=0.432), and the fibrosis stage (r=0.314). A fragmented CK-18 cutoff level of 235.5 U/L yielded sensitivity, specificity, and positive and negative predictive values of 69.0%, 64.9%, 75.5% (95% CI 62.4-85.1), and 57.1% (95% CI 42.2-70.9), respectively, for the diagnosis of NASH.
Serum fragmented CK-18 levels can be used to distinguish between NASH and NAFL. Further evaluation is required to determine whether the combined measurement of serum CK-18 and ferritin levels improves the diagnostic performance of this distinction. |
|---|---|
| AbstractList | Background/AimsThe aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH.MethodsOne hundred and eight consecutive patients with biopsy-proven NAFLD (age, 39.8±13.5 years, mean±SD; males, 67.6%) were prospectively enrolled from 10 participating centers across Korea.ResultsAccording to the original criteria for NAFLD subtypes, 67 patients (62.0%) had NASH (defined as steatosis with hepatocellular ballooning and/or Mallory-Denk bodies or fibrosis ≥2). Among those with NAFLD subtype 3 or 4, none had an NAFLD histologic activity score (NAS) below 3 points, 40.3% had a score of 3 or 4 points, and 59.7% had a score >4 points. Fragmented cytokeratin-18 (CK-18) levels were positively correlated with NAS (r=0.401), as well as NAS components such as lobular inflammation (r=0.387) and ballooning (r=0.231). Fragmented CK-18 was also correlated with aspartate aminotransferase (r=0.609), alanine aminotransferase (r=0.588), serum ferritin (r=0.432), and the fibrosis stage (r=0.314). A fragmented CK-18 cutoff level of 235.5 U/L yielded sensitivity, specificity, and positive and negative predictive values of 69.0%, 64.9%, 75.5% (95% CI 62.4-85.1), and 57.1% (95% CI 42.2-70.9), respectively, for the diagnosis of NASH.ConclusionsSerum fragmented CK-18 levels can be used to distinguish between NASH and NAFL. Further evaluation is required to determine whether the combined measurement of serum CK-18 and ferritin levels improves the diagnostic performance of this distinction. Background/Aims: The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH. Methods: One hundred and eight consecutive patients with biopsy-proven NAFLD (age, 39.8±13.5 years, mean±SD;males, 67.6%) were prospectively enrolled from 10 participating centers across Korea. Results: According to the original criteria for NAFLD subtypes, 67 patients (62.0%) had NASH (defined as steatosis with hepatocellular ballooning and/or Mallory-Denk bodies or fibrosis ≥2). Among those with NAFLD subtype 3 or 4,none had an NAFLD histologic activity score (NAS) below 3 points, 40.3% had a score of 3 or 4 points, and 59.7% had a score >4 points. Fragmented cytokeratin-18 (CK-18) levels were positively correlated with NAS (r=0.401), as well as NAShecomponents such as lobular inflammation (r=0.387) and ballooning (r=0.231). Fragmented CK-18 was also correlated with aspartate aminotransferase (r=0.609), alanine aminotransferase (r=0.588), serum ferritin (r=0.432), and the fibrosis stage (r=0.314). A fragmented CK-18 cutoff level of 235.5 U/L yielded sensitivity, specificity, and positive and negative predictive values of 69.0%, 64.9%, 75.5% (95% CI 62.4–85.1), and 57.1% (95% CI 42.2–70.9), respectively, for the diagnosis of NASH. Conclusions: Serum fragmented CK-18 levels can be used to distinguish between NASH and NAFL. Further evaluation is required to determine whether the combined measurement of serum CK-18 and ferritin levels improves the diagnostic performance of this distinction. (Clin Mol Hepatol 2013;19:120-130) KCI Citation Count: 3 The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH.BACKGROUND/AIMSThe aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH.One hundred and eight consecutive patients with biopsy-proven NAFLD (age, 39.8±13.5 years, mean±SD; males, 67.6%) were prospectively enrolled from 10 participating centers across Korea.METHODSOne hundred and eight consecutive patients with biopsy-proven NAFLD (age, 39.8±13.5 years, mean±SD; males, 67.6%) were prospectively enrolled from 10 participating centers across Korea.According to the original criteria for NAFLD subtypes, 67 patients (62.0%) had NASH (defined as steatosis with hepatocellular ballooning and/or Mallory-Denk bodies or fibrosis ≥2). Among those with NAFLD subtype 3 or 4, none had an NAFLD histologic activity score (NAS) below 3 points, 40.3% had a score of 3 or 4 points, and 59.7% had a score >4 points. Fragmented cytokeratin-18 (CK-18) levels were positively correlated with NAS (r=0.401), as well as NAS components such as lobular inflammation (r=0.387) and ballooning (r=0.231). Fragmented CK-18 was also correlated with aspartate aminotransferase (r=0.609), alanine aminotransferase (r=0.588), serum ferritin (r=0.432), and the fibrosis stage (r=0.314). A fragmented CK-18 cutoff level of 235.5 U/L yielded sensitivity, specificity, and positive and negative predictive values of 69.0%, 64.9%, 75.5% (95% CI 62.4-85.1), and 57.1% (95% CI 42.2-70.9), respectively, for the diagnosis of NASH.RESULTSAccording to the original criteria for NAFLD subtypes, 67 patients (62.0%) had NASH (defined as steatosis with hepatocellular ballooning and/or Mallory-Denk bodies or fibrosis ≥2). Among those with NAFLD subtype 3 or 4, none had an NAFLD histologic activity score (NAS) below 3 points, 40.3% had a score of 3 or 4 points, and 59.7% had a score >4 points. Fragmented cytokeratin-18 (CK-18) levels were positively correlated with NAS (r=0.401), as well as NAS components such as lobular inflammation (r=0.387) and ballooning (r=0.231). Fragmented CK-18 was also correlated with aspartate aminotransferase (r=0.609), alanine aminotransferase (r=0.588), serum ferritin (r=0.432), and the fibrosis stage (r=0.314). A fragmented CK-18 cutoff level of 235.5 U/L yielded sensitivity, specificity, and positive and negative predictive values of 69.0%, 64.9%, 75.5% (95% CI 62.4-85.1), and 57.1% (95% CI 42.2-70.9), respectively, for the diagnosis of NASH.Serum fragmented CK-18 levels can be used to distinguish between NASH and NAFL. Further evaluation is required to determine whether the combined measurement of serum CK-18 and ferritin levels improves the diagnostic performance of this distinction.CONCLUSIONSSerum fragmented CK-18 levels can be used to distinguish between NASH and NAFL. Further evaluation is required to determine whether the combined measurement of serum CK-18 and ferritin levels improves the diagnostic performance of this distinction. The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH. One hundred and eight consecutive patients with biopsy-proven NAFLD (age, 39.8±13.5 years, mean±SD; males, 67.6%) were prospectively enrolled from 10 participating centers across Korea. According to the original criteria for NAFLD subtypes, 67 patients (62.0%) had NASH (defined as steatosis with hepatocellular ballooning and/or Mallory-Denk bodies or fibrosis ≥2). Among those with NAFLD subtype 3 or 4, none had an NAFLD histologic activity score (NAS) below 3 points, 40.3% had a score of 3 or 4 points, and 59.7% had a score >4 points. Fragmented cytokeratin-18 (CK-18) levels were positively correlated with NAS (r=0.401), as well as NAS components such as lobular inflammation (r=0.387) and ballooning (r=0.231). Fragmented CK-18 was also correlated with aspartate aminotransferase (r=0.609), alanine aminotransferase (r=0.588), serum ferritin (r=0.432), and the fibrosis stage (r=0.314). A fragmented CK-18 cutoff level of 235.5 U/L yielded sensitivity, specificity, and positive and negative predictive values of 69.0%, 64.9%, 75.5% (95% CI 62.4-85.1), and 57.1% (95% CI 42.2-70.9), respectively, for the diagnosis of NASH. Serum fragmented CK-18 levels can be used to distinguish between NASH and NAFL. Further evaluation is required to determine whether the combined measurement of serum CK-18 and ferritin levels improves the diagnostic performance of this distinction. |
| Author | Song, Myeong Jun Kim, Sang Gyune Jang, Jeong Won Jung, Seung Won Jung, Eun Sun Chae, Hee Bok Bae, Si Hyun Lee, Chang Don Lee, Young Sok Yoon, Seung Kew Choi, Sang Wook Yang, Jin Mo Hur, Wonhee Kim, Young Seok Kim, Hee Kyung Kim, Chang Wook Choi, Jong Young Jo, Se Hyun |
| AuthorAffiliation | 1 Department of Internal Medicine, Soon Chun Hyang University Hospital Bucheon, Soon Chun Hyang University College of Medicine, Bucheon, Korea 6 Department of Internal Medicine, The Catholic University of Korea Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea 4 Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea 8 Department of Internal Medicine, The Catholic University of Korea St. Paul's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea 7 Department of Internal Medicine, The Catholic University of Korea Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea 5 Department of Internal Medicine, The Catholic University of Korea Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea 12 Department of Pathology, Soon Chun Hyang U |
| AuthorAffiliation_xml | – name: 1 Department of Internal Medicine, Soon Chun Hyang University Hospital Bucheon, Soon Chun Hyang University College of Medicine, Bucheon, Korea – name: 9 Department of Internal Medicine, The Catholic University of Korea St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea – name: 10 Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea – name: 6 Department of Internal Medicine, The Catholic University of Korea Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – name: 13 Department of Internal Medicine, Chungbuk National University, College of Medicine, Cheongju, Korea – name: 7 Department of Internal Medicine, The Catholic University of Korea Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea – name: 11 Department of Internal Medicine, Soon Chun Hyang University Hospital Seoul, Soon Chun Hyang University College of Medicine, Seoul, Korea – name: 2 Department of Pathology, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – name: 3 The Catholic University of Korea Liver Research Center & WHO Collaborating Center of Viral Hepatitis, The Catholic University of Korea College of Medicine, Seoul, Korea – name: 12 Department of Pathology, Soon Chun Hyang University Hospital Bucheon, Soon Chun Hyang University College of Medicine, Bucheon, Korea – name: 5 Department of Internal Medicine, The Catholic University of Korea Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea – name: 4 Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – name: 8 Department of Internal Medicine, The Catholic University of Korea St. Paul's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Young Seok surname: Kim fullname: Kim, Young Seok organization: Department of Internal Medicine, Soon Chun Hyang University Hospital Bucheon, Soon Chun Hyang University College of Medicine, Bucheon, Korea – sequence: 2 givenname: Eun Sun surname: Jung fullname: Jung, Eun Sun organization: Department of Pathology, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – sequence: 3 givenname: Wonhee surname: Hur fullname: Hur, Wonhee organization: The Catholic University of Korea Liver Research Center & WHO Collaborating Center of Viral Hepatitis, The Catholic University of Korea College of Medicine, Seoul, Korea – sequence: 4 givenname: Si Hyun surname: Bae fullname: Bae, Si Hyun organization: Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – sequence: 5 givenname: Jong Young surname: Choi fullname: Choi, Jong Young organization: Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – sequence: 6 givenname: Myeong Jun surname: Song fullname: Song, Myeong Jun organization: Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – sequence: 7 givenname: Chang Wook surname: Kim fullname: Kim, Chang Wook organization: Department of Internal Medicine, The Catholic University of Korea Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea – sequence: 8 givenname: Se Hyun surname: Jo fullname: Jo, Se Hyun organization: Department of Internal Medicine, The Catholic University of Korea Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – sequence: 9 givenname: Chang Don surname: Lee fullname: Lee, Chang Don organization: Department of Internal Medicine, The Catholic University of Korea Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, Korea – sequence: 10 givenname: Young Sok surname: Lee fullname: Lee, Young Sok organization: Department of Internal Medicine, The Catholic University of Korea Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea – sequence: 11 givenname: Sang Wook surname: Choi fullname: Choi, Sang Wook organization: Department of Internal Medicine, The Catholic University of Korea St. Paul's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea – sequence: 12 givenname: Jin Mo surname: Yang fullname: Yang, Jin Mo organization: Department of Internal Medicine, The Catholic University of Korea St. Vincent's Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea – sequence: 13 givenname: Jeong Won surname: Jang fullname: Jang, Jeong Won organization: Department of Internal Medicine, The Catholic University of Korea Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea – sequence: 14 givenname: Sang Gyune surname: Kim fullname: Kim, Sang Gyune organization: Department of Internal Medicine, Soon Chun Hyang University Hospital Bucheon, Soon Chun Hyang University College of Medicine, Bucheon, Korea – sequence: 15 givenname: Seung Won surname: Jung fullname: Jung, Seung Won organization: Department of Internal Medicine, Soon Chun Hyang University Hospital Seoul, Soon Chun Hyang University College of Medicine, Seoul, Korea – sequence: 16 givenname: Hee Kyung surname: Kim fullname: Kim, Hee Kyung organization: Department of Pathology, Soon Chun Hyang University Hospital Bucheon, Soon Chun Hyang University College of Medicine, Bucheon, Korea – sequence: 17 givenname: Hee Bok surname: Chae fullname: Chae, Hee Bok organization: Department of Internal Medicine, Chungbuk National University, College of Medicine, Cheongju, Korea – sequence: 18 givenname: Seung Kew surname: Yoon fullname: Yoon, Seung Kew organization: Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23837136$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001776492$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNp9Uk1vEzEUtFARbUN_ABdkiQuXBH_sru0LUlWVElGBhIrEzfJ6vVmnjh1sJyg_gP-NN6GF9IAvtp7nzcx7mnNw4oM3ALzCaEZpjd7p1TAjCNMZFjMywwQ9A2eEcDYlvP5-8vBmhJ-Ci5SWqByGSC3oC3BKKKcM0-YM_PocvPVblezWwHU0ndU5xARDD4uecjoMwVkNUzYqh8GsVbbZJmg9_BSiUR6OFeNzgj9tHuBgUw4uLKxWzu0KY9gaf0zVq5x30BXBCDubjErmJXjeK5fMxZ97Ar59uL67-ji9_XIzv7q8neqaNHmKlWA1RqiMVmOqW6F113ZNW9ZQC9bUplPcGEwJahjjnHe0EzVFPWe8J4QyOgFvD7w-9vJeWxmU3d-LIO-jvPx6N5eVIFUBT8D8AO2CWsp1tCsVd3v8vhDiQqqYrXZGdkWTo9ZQ3nYV5UwghVVFeIMqjLUeZd8fuNabdmU6XdYVlTsiPf7xdiiWtpIyhHlV_fVd9vljY1KWK5u0cU55EzZJYioEaaqqQQX65gl0GTaxrD9JiknDMGdsdPT6X0ePVh6CUQD4ANAxpBRN_wjBSI75kyV_csyfxEISWfJXetiTHm1zSUcYh7LuP52_AVYx4cs |
| CitedBy_id | crossref_primary_10_1097_INF_0000000000000530 crossref_primary_10_3390_life10100230 crossref_primary_10_1007_s11901_017_0369_3 crossref_primary_10_3390_ijms17040562 crossref_primary_10_1016_j_atherosclerosis_2022_08_011 crossref_primary_10_1186_s12944_024_02396_3 crossref_primary_10_3389_fmed_2022_934989 crossref_primary_10_3390_ijms17040548 crossref_primary_10_1097_CM9_0000000000002603 crossref_primary_10_1186_1471_230X_14_39 crossref_primary_10_1371_journal_pone_0238717 crossref_primary_10_4166_kjg_2014_64_4_206 crossref_primary_10_1080_13813455_2020_1745851 crossref_primary_10_4103_1687_9945_337837 crossref_primary_10_5223_pghn_2014_17_4_248 crossref_primary_10_1002_jgh3_12716 crossref_primary_10_1155_2014_846923 crossref_primary_10_4166_kjg_2014_64_1_31 crossref_primary_10_1016_j_cgh_2017_08_024 crossref_primary_10_3350_cmh_2013_19_2_116 crossref_primary_10_1371_journal_pmed_1001680 crossref_primary_10_1002_hep_29466 crossref_primary_10_1016_j_jhep_2018_05_036 crossref_primary_10_1016_j_cca_2025_120147 crossref_primary_10_1111_eci_13939 crossref_primary_10_3390_biomedicines11030883 |
| Cites_doi | 10.1002/hep.24268 10.1016/j.jhep.2011.12.025 10.1002/hep.20701 10.1053/j.gastro.2005.03.084 10.1002/hep.21327 10.1111/j.1572-0241.1999.01377.x 10.1016/j.jhep.2010.05.018 10.1111/j.1365-2036.2006.02719.x 10.1055/s-0028-1091978 10.1136/gut.2004.060251 10.1016/j.yexcr.2007.04.024 10.1053/gast.2002.36572 10.1161/CIRCULATIONAHA.109.192644 10.1002/hep.21223 10.1053/jhep.2003.50161 10.2337/diabetes.50.8.1844 10.1007/s00535-010-0305-6 10.1002/hep.22429 10.1016/S0016-5085(03)00907-7 10.3109/07853890.2010.518623 10.1002/hep.23784 10.1016/j.cgh.2008.11.005 10.1016/j.metabol.2012.01.007 10.2337/diacare.20.7.1087 10.1016/j.jhep.2006.09.018 10.1111/j.1572-0241.2007.01322.x 10.1016/S0092-8674(04)00046-7 10.1053/j.gastro.2012.04.001 10.1111/j.1440-1746.2005.04086.x 10.3350/kjhep.2011.17.1.19 10.1002/hep.23527 10.1002/hep.22896 10.1111/j.1365-2796.1994.tb00802.x 10.1002/hep.23050 10.1136/gut.2009.205088 10.1309/WWNE-KW2C-4KTW-PTJ5 10.1053/j.gastro.2005.04.014 10.1016/S0016-5085(99)70506-8 10.1002/hep.24376 10.1002/hep.24706 10.1002/hep.23433 10.1002/hep.21768 10.1111/j.1478-3231.2011.02488.x 10.1053/j.gastro.2010.02.058 10.1097/MCG.0b013e3181bdefe2 10.1002/hep.20283 10.1002/hep.23594 |
| ContentType | Journal Article |
| Copyright | 2013. This work is published under http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2013 by The Korean Association for the Study of the Liver 2013 |
| Copyright_xml | – notice: 2013. This work is published under http://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2013 by The Korean Association for the Study of the Liver 2013 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PHGZM PHGZT PIMPY PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA ACYCR |
| DOI | 10.3350/cmh.2013.19.2.120 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) ProQuest Health & Medical Collection (NC LIVE) ProQuest Central (purchase pre-March 2016) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central (subscription) ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals Korean Citation Index |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 7X7 name: ProQuest Health & Medical Collection (NC LIVE) url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2287-285X |
| EndPage | 130 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_492422 oai_doaj_org_article_dee180be38bd438790a1a42860411cc7 PMC3701844 23837136 10_3350_cmh_2013_19_2_120 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Republic of Korea |
| GeographicLocations_xml | – name: Republic of Korea |
| GroupedDBID | 5-W 7X7 8FI 8FJ 8JR 8XY 9ZL AAYXX ABUWG ACYCR ADBBV ADRAZ AFKRA ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV BENPR CCPQU CITATION DIK EBD EF. EMOBN FYUFA GROUPED_DOAJ HMCUK HYE IPNFZ KQ8 M48 PGMZT PHGZM PHGZT PIMPY RIG RNS RPM SV3 UKHRP CGR CUY CVF ECM EIF M~E NPM OK1 3V. 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQQKQ PQUKI PRINS 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c526t-1a975100228513cb9ccdbd6b20159765eda8ee1320677888d3d9530f878f22373 |
| IEDL.DBID | M48 |
| ISSN | 2287-2728 2287-285X |
| IngestDate | Tue Nov 21 21:18:27 EST 2023 Wed Aug 27 01:21:05 EDT 2025 Thu Aug 21 13:51:58 EDT 2025 Thu Jul 10 19:16:11 EDT 2025 Mon Jun 30 14:38:03 EDT 2025 Thu Jan 02 22:17:22 EST 2025 Tue Jul 01 04:27:40 EDT 2025 Thu Apr 24 23:01:39 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Cytokeratin-18 Nonalcoholic fatty liver disease Ferritin |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c526t-1a975100228513cb9ccdbd6b20159765eda8ee1320677888d3d9530f878f22373 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors equally contributed to this work. G704-001530.2013.19.2.006 http://www.e-cmh.org/ |
| OpenAccessLink | https://www.proquest.com/docview/3126718777?pq-origsite=%requestingapplication% |
| PMID | 23837136 |
| PQID | 3126718777 |
| PQPubID | 7084873 |
| PageCount | 11 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_492422 doaj_primary_oai_doaj_org_article_dee180be38bd438790a1a42860411cc7 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3701844 proquest_miscellaneous_1399264460 proquest_journals_3126718777 pubmed_primary_23837136 crossref_primary_10_3350_cmh_2013_19_2_120 crossref_citationtrail_10_3350_cmh_2013_19_2_120 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-06-01 |
| PublicationDateYYYYMMDD | 2013-06-01 |
| PublicationDate_xml | – month: 06 year: 2013 text: 2013-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Korea (South) |
| PublicationPlace_xml | – name: Korea (South) – name: Seoul |
| PublicationTitle | Clinical and molecular hepatology |
| PublicationTitleAlternate | Clin Mol Hepatol |
| PublicationYear | 2013 |
| Publisher | Korean Association for the Study of the Liver The Korean Association for the Study of the Liver 대한간학회 |
| Publisher_xml | – name: Korean Association for the Study of the Liver – name: The Korean Association for the Study of the Liver – name: 대한간학회 |
| References | Brunt (10.3350/cmh.2013.19.2.120_ref7) 1999; 94 Zatloukal (10.3350/cmh.2013.19.2.120_ref38) 2007; 313 Shen (10.3350/cmh.2013.19.2.120_ref21) 2012; 56 Adams (10.3350/cmh.2013.19.2.120_ref10) 2005; 129 Shimada (10.3350/cmh.2013.19.2.120_ref26) 2007; 102 Kleiner (10.3350/cmh.2013.19.2.120_ref16) 2005; 41 Starley (10.3350/cmh.2013.19.2.120_ref12) 2010; 51 Ratziu (10.3350/cmh.2013.19.2.120_ref15) 2005; 128 Marchesini (10.3350/cmh.2013.19.2.120_ref4) 2003; 37 Matteoni (10.3350/cmh.2013.19.2.120_ref9) 1999; 116 Kowdley (10.3350/cmh.2013.19.2.120_ref18) 2012; 55 Ekstedt (10.3350/cmh.2013.19.2.120_ref8) 2006; 44 Bonnefont-Rousselot (10.3350/cmh.2013.19.2.120_ref25) 2006; 23 Milner (10.3350/cmh.2013.19.2.120_ref20) 2009; 49 Park (10.3350/cmh.2013.19.2.120_ref2) 2011; 17 Li (10.3350/cmh.2013.19.2.120_ref23) 2010; 53 Zelber-Sagi (10.3350/cmh.2013.19.2.120_ref46) 2007; 46 Sumida (10.3350/cmh.2013.19.2.120_ref27) 2011; 46 Danial (10.3350/cmh.2013.19.2.120_ref29) 2004; 116 Feldstein (10.3350/cmh.2013.19.2.120_ref39) 2004; 40 Chalasani (10.3350/cmh.2013.19.2.120_ref42) 2012; 142 Feldstein (10.3350/cmh.2013.19.2.120_ref19) 2009; 50 Park (10.3350/cmh.2013.19.2.120_ref3) 2006; 21 Neuschwander-Tetri (10.3350/cmh.2013.19.2.120_ref37) 2010; 52 Musso (10.3350/cmh.2013.19.2.120_ref40) 2011; 43 Fontana (10.3350/cmh.2013.19.2.120_ref14) 2010; 138 Younossi (10.3350/cmh.2013.19.2.120_ref33) 2011; 53 Lazo (10.3350/cmh.2013.19.2.120_ref1) 2008; 28 Wong (10.3350/cmh.2013.19.2.120_ref11) 2010; 59 Feldstein (10.3350/cmh.2013.19.2.120_ref28) 2003; 125 Sanyal (10.3350/cmh.2013.19.2.120_ref6) 2002; 123 Haffner (10.3350/cmh.2013.19.2.120_ref31) 1997; 20 Bell (10.3350/cmh.2013.19.2.120_ref43) 1994; 236 Marchesini (10.3350/cmh.2013.19.2.120_ref5) 2001; 50 Turlin (10.3350/cmh.2013.19.2.120_ref44) 2001; 116 Fracanzani (10.3350/cmh.2013.19.2.120_ref47) 2008; 48 Rafiq (10.3350/cmh.2013.19.2.120_ref34) 2009; 7 Sanyal (10.3350/cmh.2013.19.2.120_ref35) 2011; 54 Wieckowska (10.3350/cmh.2013.19.2.120_ref41) 2007; 46 Manousou (10.3350/cmh.2013.19.2.120_ref45) 2011; 31 Assy (10.3350/cmh.2013.19.2.120_ref24) 2005; 54 Ascha (10.3350/cmh.2013.19.2.120_ref13) 2010; 51 Tsutsui (10.3350/cmh.2013.19.2.120_ref36) 2010; 44 Alberti (10.3350/cmh.2013.19.2.120_ref32) 2009; 120 Kim (10.3350/cmh.2013.19.2.120_ref17) 2012; 61 Wieckowska (10.3350/cmh.2013.19.2.120_ref30) 2006; 44 Li (10.3350/cmh.2013.19.2.120_ref22) 2010; 51 17531973 - Exp Cell Res. 2007 Jun 10;313(10):2033-49 21457446 - Liver Int. 2011 May;31(5):730-9 17006923 - Hepatology. 2006 Oct;44(4):865-73 21520200 - Hepatology. 2011 Jul;54(1):344-53 19049831 - Clin Gastroenterol Hepatol. 2009 Feb;7(2):234-8 19805654 - Circulation. 2009 Oct 20;120(16):1640-5 22656328 - Gastroenterology. 2012 Jun;142(7):1592-609 18752331 - Hepatology. 2008 Sep;48(3):792-8 15239102 - Hepatology. 2004 Jul;40(1):185-94 20581244 - Gut. 2010 Jul;59(7):969-74 19585618 - Hepatology. 2009 Oct;50(4):1072-8 20675007 - J Hepatol. 2010 Nov;53(5):934-40 9203442 - Diabetes Care. 1997 Jul;20(7):1087-92 15940625 - Gastroenterology. 2005 Jun;128(7):1898-906 16799979 - Hepatology. 2006 Jul;44(1):27-33 16012941 - Gastroenterology. 2005 Jul;129(1):113-21 20842510 - J Gastroenterol. 2011 Feb;46(2):257-68 22314419 - J Hepatol. 2012 Jun;56(6):1363-70 10484010 - Am J Gastroenterol. 1999 Sep;94(9):2467-74 20648476 - Hepatology. 2010 Sep;52(3):913-24 15915461 - Hepatology. 2005 Jun;41(6):1313-21 10348825 - Gastroenterology. 1999 Jun;116(6):1413-9 16706825 - J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 1):138-43 19475694 - Hepatology. 2009 Jun;49(6):1926-34 17511754 - Am J Gastroenterol. 2007 Sep;102(9):1931-8 21953442 - Hepatology. 2012 Jan;55(1):77-85 15831928 - Gut. 2005 May;54(5):729 18956290 - Semin Liver Dis. 2008 Nov;28(4):339-50 11473047 - Diabetes. 2001 Aug;50(8):1844-50 8077889 - J Intern Med. 1994 Sep;236(3):315-22 17150278 - J Hepatol. 2007 Apr;46(4):700-7 23837135 - Clin Mol Hepatol. 2013 Jun;19(2):116-9 20041411 - Hepatology. 2010 May;51(5):1865-6 20209604 - Hepatology. 2010 Jun;51(6):1972-8 20432259 - Hepatology. 2010 May;51(5):1820-32 12891546 - Gastroenterology. 2003 Aug;125(2):437-43 21494074 - Korean J Hepatol. 2011 Mar;17(1):19-26 12404245 - Gastroenterology. 2002 Nov;123(5):1705-25 17661414 - Hepatology. 2007 Aug;46(2):582-9 20211180 - Gastroenterology. 2010 Jun;138(7):2321-31, 2331.e1-2 12668987 - Hepatology. 2003 Apr;37(4):917-23 20104187 - J Clin Gastroenterol. 2010 Jul;44(6):440-7 14744432 - Cell. 2004 Jan 23;116(2):205-19 21039302 - Ann Med. 2011 Dec;43(8):617-49 21360720 - Hepatology. 2011 Jun;53(6):1874-82 16393285 - Aliment Pharmacol Ther. 2006 Jan 1;23(1):91-8 11488074 - Am J Clin Pathol. 2001 Aug;116(2):263-70 22386931 - Metabolism. 2012 Aug;61(8):1182-8 |
| References_xml | – volume: 53 start-page: 1874 year: 2011 ident: 10.3350/cmh.2013.19.2.120_ref33 publication-title: Hepatology doi: 10.1002/hep.24268 – volume: 56 start-page: 1363 year: 2012 ident: 10.3350/cmh.2013.19.2.120_ref21 publication-title: J Hepatol doi: 10.1016/j.jhep.2011.12.025 – volume: 41 start-page: 1313 year: 2005 ident: 10.3350/cmh.2013.19.2.120_ref16 publication-title: Hepatology doi: 10.1002/hep.20701 – volume: 128 start-page: 1898 year: 2005 ident: 10.3350/cmh.2013.19.2.120_ref15 publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.03.084 – volume: 44 start-page: 865 year: 2006 ident: 10.3350/cmh.2013.19.2.120_ref8 publication-title: Hepatology doi: 10.1002/hep.21327 – volume: 94 start-page: 2467 year: 1999 ident: 10.3350/cmh.2013.19.2.120_ref7 publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.1999.01377.x – volume: 53 start-page: 934 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref23 publication-title: J Hepatol doi: 10.1016/j.jhep.2010.05.018 – volume: 23 start-page: 91 year: 2006 ident: 10.3350/cmh.2013.19.2.120_ref25 publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2006.02719.x – volume: 28 start-page: 339 year: 2008 ident: 10.3350/cmh.2013.19.2.120_ref1 publication-title: Semin Liver Dis doi: 10.1055/s-0028-1091978 – volume: 54 start-page: 729 year: 2005 ident: 10.3350/cmh.2013.19.2.120_ref24 publication-title: Gut doi: 10.1136/gut.2004.060251 – volume: 313 start-page: 2033 year: 2007 ident: 10.3350/cmh.2013.19.2.120_ref38 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2007.04.024 – volume: 123 start-page: 1705 year: 2002 ident: 10.3350/cmh.2013.19.2.120_ref6 publication-title: Gastroenterology doi: 10.1053/gast.2002.36572 – volume: 120 start-page: 1640 year: 2009 ident: 10.3350/cmh.2013.19.2.120_ref32 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.192644 – volume: 44 start-page: 27 year: 2006 ident: 10.3350/cmh.2013.19.2.120_ref30 publication-title: Hepatology doi: 10.1002/hep.21223 – volume: 37 start-page: 917 year: 2003 ident: 10.3350/cmh.2013.19.2.120_ref4 publication-title: Hepatology doi: 10.1053/jhep.2003.50161 – volume: 50 start-page: 1844 year: 2001 ident: 10.3350/cmh.2013.19.2.120_ref5 publication-title: Diabetes doi: 10.2337/diabetes.50.8.1844 – volume: 46 start-page: 257 year: 2011 ident: 10.3350/cmh.2013.19.2.120_ref27 publication-title: J Gastroenterol doi: 10.1007/s00535-010-0305-6 – volume: 48 start-page: 792 year: 2008 ident: 10.3350/cmh.2013.19.2.120_ref47 publication-title: Hepatology doi: 10.1002/hep.22429 – volume: 125 start-page: 437 year: 2003 ident: 10.3350/cmh.2013.19.2.120_ref28 publication-title: Gastroenterology doi: 10.1016/S0016-5085(03)00907-7 – volume: 43 start-page: 617 year: 2011 ident: 10.3350/cmh.2013.19.2.120_ref40 publication-title: Ann Med doi: 10.3109/07853890.2010.518623 – volume: 52 start-page: 913 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref37 publication-title: Hepatology doi: 10.1002/hep.23784 – volume: 7 start-page: 234 year: 2009 ident: 10.3350/cmh.2013.19.2.120_ref34 publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2008.11.005 – volume: 61 start-page: 1182 year: 2012 ident: 10.3350/cmh.2013.19.2.120_ref17 publication-title: Metabolism doi: 10.1016/j.metabol.2012.01.007 – volume: 20 start-page: 1087 year: 1997 ident: 10.3350/cmh.2013.19.2.120_ref31 publication-title: Diabetes Care doi: 10.2337/diacare.20.7.1087 – volume: 46 start-page: 700 year: 2007 ident: 10.3350/cmh.2013.19.2.120_ref46 publication-title: J Hepatol doi: 10.1016/j.jhep.2006.09.018 – volume: 102 start-page: 1931 year: 2007 ident: 10.3350/cmh.2013.19.2.120_ref26 publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2007.01322.x – volume: 116 start-page: 205 year: 2004 ident: 10.3350/cmh.2013.19.2.120_ref29 publication-title: Cell doi: 10.1016/S0092-8674(04)00046-7 – volume: 142 start-page: 1592 year: 2012 ident: 10.3350/cmh.2013.19.2.120_ref42 publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.04.001 – volume: 21 start-page: 138 year: 2006 ident: 10.3350/cmh.2013.19.2.120_ref3 publication-title: J Gastroenterol Hepatol doi: 10.1111/j.1440-1746.2005.04086.x – volume: 17 start-page: 19 year: 2011 ident: 10.3350/cmh.2013.19.2.120_ref2 publication-title: Korean J Hepatol doi: 10.3350/kjhep.2011.17.1.19 – volume: 51 start-page: 1972 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref13 publication-title: Hepatology doi: 10.1002/hep.23527 – volume: 49 start-page: 1926 year: 2009 ident: 10.3350/cmh.2013.19.2.120_ref20 publication-title: Hepatology doi: 10.1002/hep.22896 – volume: 236 start-page: 315 year: 1994 ident: 10.3350/cmh.2013.19.2.120_ref43 publication-title: J Intern Med doi: 10.1111/j.1365-2796.1994.tb00802.x – volume: 50 start-page: 1072 year: 2009 ident: 10.3350/cmh.2013.19.2.120_ref19 publication-title: Hepatology doi: 10.1002/hep.23050 – volume: 59 start-page: 969 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref11 publication-title: Gut doi: 10.1136/gut.2009.205088 – volume: 116 start-page: 263 year: 2001 ident: 10.3350/cmh.2013.19.2.120_ref44 publication-title: Am J Clin Pathol doi: 10.1309/WWNE-KW2C-4KTW-PTJ5 – volume: 129 start-page: 113 year: 2005 ident: 10.3350/cmh.2013.19.2.120_ref10 publication-title: Gastroenterology doi: 10.1053/j.gastro.2005.04.014 – volume: 116 start-page: 1413 year: 1999 ident: 10.3350/cmh.2013.19.2.120_ref9 publication-title: Gastroenterology doi: 10.1016/S0016-5085(99)70506-8 – volume: 54 start-page: 344 year: 2011 ident: 10.3350/cmh.2013.19.2.120_ref35 publication-title: Hepatology doi: 10.1002/hep.24376 – volume: 55 start-page: 77 year: 2012 ident: 10.3350/cmh.2013.19.2.120_ref18 publication-title: Hepatology doi: 10.1002/hep.24706 – volume: 51 start-page: 1865 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref22 publication-title: Hepatology doi: 10.1002/hep.23433 – volume: 46 start-page: 582 year: 2007 ident: 10.3350/cmh.2013.19.2.120_ref41 publication-title: Hepatology doi: 10.1002/hep.21768 – volume: 31 start-page: 730 year: 2011 ident: 10.3350/cmh.2013.19.2.120_ref45 publication-title: Liver Int doi: 10.1111/j.1478-3231.2011.02488.x – volume: 138 start-page: 2321 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref14 publication-title: Gastroenterology doi: 10.1053/j.gastro.2010.02.058 – volume: 44 start-page: 440 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref36 publication-title: J Clin Gastroenterol doi: 10.1097/MCG.0b013e3181bdefe2 – volume: 40 start-page: 185 year: 2004 ident: 10.3350/cmh.2013.19.2.120_ref39 publication-title: Hepatology doi: 10.1002/hep.20283 – volume: 51 start-page: 1820 year: 2010 ident: 10.3350/cmh.2013.19.2.120_ref12 publication-title: Hepatology doi: 10.1002/hep.23594 – reference: 15239102 - Hepatology. 2004 Jul;40(1):185-94 – reference: 15940625 - Gastroenterology. 2005 Jun;128(7):1898-906 – reference: 19585618 - Hepatology. 2009 Oct;50(4):1072-8 – reference: 18956290 - Semin Liver Dis. 2008 Nov;28(4):339-50 – reference: 20211180 - Gastroenterology. 2010 Jun;138(7):2321-31, 2331.e1-2 – reference: 15831928 - Gut. 2005 May;54(5):729 – reference: 11488074 - Am J Clin Pathol. 2001 Aug;116(2):263-70 – reference: 12668987 - Hepatology. 2003 Apr;37(4):917-23 – reference: 15915461 - Hepatology. 2005 Jun;41(6):1313-21 – reference: 19805654 - Circulation. 2009 Oct 20;120(16):1640-5 – reference: 21039302 - Ann Med. 2011 Dec;43(8):617-49 – reference: 16393285 - Aliment Pharmacol Ther. 2006 Jan 1;23(1):91-8 – reference: 19475694 - Hepatology. 2009 Jun;49(6):1926-34 – reference: 22386931 - Metabolism. 2012 Aug;61(8):1182-8 – reference: 10348825 - Gastroenterology. 1999 Jun;116(6):1413-9 – reference: 20675007 - J Hepatol. 2010 Nov;53(5):934-40 – reference: 20432259 - Hepatology. 2010 May;51(5):1820-32 – reference: 14744432 - Cell. 2004 Jan 23;116(2):205-19 – reference: 19049831 - Clin Gastroenterol Hepatol. 2009 Feb;7(2):234-8 – reference: 20104187 - J Clin Gastroenterol. 2010 Jul;44(6):440-7 – reference: 10484010 - Am J Gastroenterol. 1999 Sep;94(9):2467-74 – reference: 18752331 - Hepatology. 2008 Sep;48(3):792-8 – reference: 11473047 - Diabetes. 2001 Aug;50(8):1844-50 – reference: 20648476 - Hepatology. 2010 Sep;52(3):913-24 – reference: 23837135 - Clin Mol Hepatol. 2013 Jun;19(2):116-9 – reference: 21494074 - Korean J Hepatol. 2011 Mar;17(1):19-26 – reference: 12891546 - Gastroenterology. 2003 Aug;125(2):437-43 – reference: 16799979 - Hepatology. 2006 Jul;44(1):27-33 – reference: 20041411 - Hepatology. 2010 May;51(5):1865-6 – reference: 9203442 - Diabetes Care. 1997 Jul;20(7):1087-92 – reference: 22314419 - J Hepatol. 2012 Jun;56(6):1363-70 – reference: 21457446 - Liver Int. 2011 May;31(5):730-9 – reference: 20209604 - Hepatology. 2010 Jun;51(6):1972-8 – reference: 20581244 - Gut. 2010 Jul;59(7):969-74 – reference: 21360720 - Hepatology. 2011 Jun;53(6):1874-82 – reference: 22656328 - Gastroenterology. 2012 Jun;142(7):1592-609 – reference: 17006923 - Hepatology. 2006 Oct;44(4):865-73 – reference: 17150278 - J Hepatol. 2007 Apr;46(4):700-7 – reference: 12404245 - Gastroenterology. 2002 Nov;123(5):1705-25 – reference: 8077889 - J Intern Med. 1994 Sep;236(3):315-22 – reference: 17511754 - Am J Gastroenterol. 2007 Sep;102(9):1931-8 – reference: 21953442 - Hepatology. 2012 Jan;55(1):77-85 – reference: 16706825 - J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 1):138-43 – reference: 21520200 - Hepatology. 2011 Jul;54(1):344-53 – reference: 17661414 - Hepatology. 2007 Aug;46(2):582-9 – reference: 17531973 - Exp Cell Res. 2007 Jun 10;313(10):2033-49 – reference: 16012941 - Gastroenterology. 2005 Jul;129(1):113-21 – reference: 20842510 - J Gastroenterol. 2011 Feb;46(2):257-68 |
| SSID | ssj0000702593 |
| Score | 2.0488362 |
| Snippet | The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from... Background/AimsThe aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic... Background/Aims: The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic... |
| SourceID | nrf doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 120 |
| SubjectTerms | Adult Aged Aged, 80 and over Alanine Transaminase - blood Apoptosis Asian Continental Ancestry Group Aspartate Aminotransferases - blood Biomarkers Biomarkers - blood Biopsy Blood pressure Body mass index Cholesterol Correlation analysis Cytokeratin-18 Data analysis Diabetes Fatty Liver - classification Fatty Liver - metabolism Fatty Liver - pathology Female Ferritin Ferritins - blood Fibrosis - complications Gastrointestinal surgery Glucose High density lipoprotein Hospitals Humans Hypertension Inflammation Insulin resistance Keratin-18 - analysis Laboratories Liver diseases Male Metabolic syndrome Middle Aged Non-alcoholic Fatty Liver Disease Nonalcoholic fatty liver disease Obesity Original Predictive Value of Tests Prospective Studies Republic of Korea Severity of Illness Index Young Adult 내과학 |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gL4k2gICNxQsrWj8R2joCoCqg9Uak3y6_QqNuk2k2R-gP438w46WoXIbhwipSHY_ubeGY8k28IeatcbLmvQgn41mXVpFh6mVTpHZKD-BZwwX-Hj0_U0Wn15aw-2yr1hTlhEz3wNHEHMSVumE_S-FhJoxvmuAObWbGK8xDyf-Sg87acqbwGa9DlmXFXgEtQCi3MFNKUsmYH4RLDEFwueLMQC461vreUUubuB1XTr9o_mZ2_Z09uqaPDB-T-bEfS91P_H5I7qX9E7h7PkfLH5OcJ7rP-cJidTq9WeB7r6tChpT0a37kwbhcogjwO5wkTq8duTbuefh3AkOzpzLi6prhVSzMv8bxOLm8o7kSkfrep1o3jDV1ioged4z5PyOnhp28fj8q55EIZaqHGkrtG1zyT4tRcBt-EEH1UHmYLPA9Vp-gMACJFJp4zJsrY1JK1RpsWDA0tn5I9eHV6TiiYYi0PrcJQZlXVvokMmmJRGpd0HWVB2O2c2zDzkWNZjKUFvwRhsgCTRZgsb6ywAFNB3m0euZrIOP528wcEcnMj8mjnEyBddpYu-y_pKsgbEAN7Ebr8PB6_D_ZiZcHb-GwrcF6FKMj-rZDYeQFYW8mFArWvNTaxuQyfLsZjXJ-G67XlSAoM9qiCvj6bZGrTW4E7B1yqgugdadsZzu6VvjvP9OBSM3Dbqxf_Y_wvyT0x1f8oGd8ne-PqOr0CK2z0r_MH9wvZGi9O priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Health & Medical Collection (NC LIVE) dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagSIgL4k2gICNxQso2thM7OSFAVAXUnqi0N8uvtFGXZNmkSP0B_G9mEm_oItTTSnl4nXzj8bzyDSFvpfE1s7lLAd8izavgUyuCTK1BchBbAy747fDxiTw6zb8ui2UMuPWxrHKrE0dF7TuHMfIDwbgEPaqUer_-mWLXKMyuxhYat8kdpC5DqVZLNcdYQJz5xLvLwTFIueLllNgUosgO3A9MRjCxYNWCLxh2_L62NY0M_rDhtJv6f8bnvzWU1zalwwfkfrQm6YcJ_ofkVmgfkbvHMV_-mPw-wWjrL4M16nS9wePYXYd2NW3RBB_b4zaOItRDdx6wvHpoetq09FsH5mRLI-9qTzFgS0d24qgtV1cU4xGh3R2qNsNwRVdY7kFj9ucJOT38_P3TURobL6Su4HJImalUwUZqnIIJZyvnvPXSwtsC_0MWwZsyBPz4GunnytILXxUiq0tV1mBuKPGU7MFfh-eEgkFWM1dLTGjmeWErn8FQmRelCarwIiHZ9p1rF1nJsTnGSoN3gjBpgEkjTJpVmmuAKSHv5lvWEyXHTRd_RCDnC5FNezzQbc50XJzaw8OUmQ2itD4Xpaoywwz4ZTLLGXNOJeQNiIG-cM14P_6edfpio8Hn-KJzcGE5T8j-Vkh0VAO9_iu0MMR8GhYwZmVMG7rLXjOkBgarVMJcn00yNc-WY_yACZkQtSNtO4-ze6ZtzkeScKEycN7zFzdP6yW5x6f-HmnG9snesLkMr8DKGuzrcSn9Ac2DJzw priority: 102 providerName: ProQuest |
| Title | Noninvasive predictors of nonalcoholic steatohepatitis in Korean patients with histologically proven nonalcoholic fatty liver disease |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23837136 https://www.proquest.com/docview/3126718777 https://www.proquest.com/docview/1399264460 https://pubmed.ncbi.nlm.nih.gov/PMC3701844 https://doaj.org/article/dee180be38bd438790a1a42860411cc7 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001776492 |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Clinical and Molecular Hepatology, 2013, 19(2), , pp.120-130 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLbGJiFeEPcVRmUknpBSYju2kweEGNo0QK0QYlLfrPiSrVpJRpoh-gP435zjphVFFeIpUi5O4nMcf985zncIealKXzGbuQTsK5OsCD6xIqjEligOYiuwC_47PJ6os_Ps41RO98i6vFXfgYud1A7rSZ2389HP78u3MODfIOMUMn3tvmFWgYkRK0Z8xDgw-AOYmDQWNBj3aD9-mDVM8FGGlwNPSHgup6s85-5WtmaqKOgP80_dVruw6N9LKv-Yo07vkbs9uKTvVt5wn-yF-gG5Pe7T5w_JrwkGX3-UuGSdXre4H4vt0KaiNSLyWC135ihavmsuA6627mYLOqvppwbQZU17GdYFxfgtjWLF_cdzvqQYngj1dlNV2XVLOsfVH7RPBj0i56cnX9-fJX0dhsRJrrqElYWWLCrlSCacLZzz1isLvQV0RMngyzwE_Bcb1ejy3AtfSJFWuc4rQB9aPCb7cOtwSCjgs4q5SmF-M8ukLXwKTaVe5GXQ0osBSdd9blwvUo61MuYGyAqayYCZDJrJsMJwA2YakFebS65XCh3_OvkYDbk5EcW1446mvTD9WDUeXiZPbRC59ZnIdZGWrASaptKMMef0gLwANzBXbhavx-1FY65aAxTkg8mA0XI-IEdrJzFrpzaCcQVYQGtsYnMYxjMmaco6NDcLw1ApGECqgmd9svKpzdNyDCcwoQZEb3nb1utsH6lnl1EzXOgUuHz29D_u-4zc4auaH0nKjsh-196E54C8Ojskt_RUD8nB8cnk85dhjF8M4xj7DTgiMBQ |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VIgEXxJtAgUWCC5JT767tXR8Q4lUlpMmplXJbvA-3VoMdEheUH8Df4TcyYzuhQai3niz5sV57Zue93xDyKslczkxkA6BvHESpd4ERPglMhuAgJge64N7h8SQZHEdfpvF0h_xe74XBssq1TGwEtassxsj3BeMJyFEp5bv59wC7RmF2dd1Co2WLkV_9BJdt-Xb4Cej7mvODz0cfB0HXVSCwMU_qgGWpjFmD-xIzYU1qrTMuMaAJwbhOYu8y5T3uLEZsNaWccGkswlxJlYMulQLGvUaug-IN0dmTU7mJ6cDy4S3OLwwuAy65ahOpQsThvv2GyQ8m-izt8z7DDuMXVGHTMQAUXLnI_2fs_luzeUEJHtwhtzvrlb5v2e0u2fHlPXJj3OXn75NfE4zu_siwJp7OF3geu_nQKqclmvxNO97CUmStujr1WM5dF0talHRUgfla0g7ndUkxQEwbNOROOs9WFOMfvtweKs_qekVnWF5Cu2zTA3J8JSR5SHbh1f4xoWAA5szmCSZQoyg2qQthqNAJlXkZO9Ej4fqfa9uhoGMzjpkGbwjJpIFMGsmkWaq5BjL1yJvNI_MWAuSymz8gITc3Inp3c6JanOhOGGgHH6NC44UyLhJKpmHGMvADkzBizFrZIy-BDfSZLZrn8XhS6bOFBh9nqCNwmTnvkb01k-hO7Cz130UCQ2wug8DALFBW-up8qRlCEYMVnMBcH7U8tZktx3gFE0mPyC1u2_qc7StlcdqAkgsZMhVFTy6f1gtyc3A0PtSHw8noKbnF294iQcj2yG69OPfPwMKrzfNmWVHy9arX8R9bCGG1 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Noninvasive+predictors+of+nonalcoholic+steatohepatitis+in+Korean+patients+with+histologically+proven+nonalcoholic+fatty+liver+disease&rft.jtitle=Clinical+and+molecular+hepatology&rft.au=Kim%2C+Young+Seok&rft.au=Jung%2C+Eun+Sun&rft.au=Hur%2C+Wonhee&rft.au=Bae%2C+Si+Hyun&rft.date=2013-06-01&rft.issn=2287-285X&rft.eissn=2287-285X&rft.volume=19&rft.issue=2&rft.spage=120&rft_id=info:doi/10.3350%2Fcmh.2013.19.2.120&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2287-2728&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2287-2728&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2287-2728&client=summon |