Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1β on the Risk of Silicosis: A Case-Control Study

• Published in: PloS one Vol. 10; no. 10; p. e0140952
• Main Authors: Weng, Shaofan, Wang, Lihua, Rong, Yi, Liu, Yuewei, Wang, Xin, Guan, Hongyu, Chen, Weihong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.10.2015; Public Library of Science (PLoS)
• Subjects: Adjustment; Age Factors; Aged; Apoptosis; Carrier Proteins - genetics; Case studies; Case-Control Studies; Caspase; Caspase 1 - genetics; Caspase-1; Chronic obstructive pulmonary disease; Coal; Confidence intervals; Cytokines; Dust; Dust control; Environmental health; Exposure; Family medical history; Female; Gene Expression; Genes; Genetic Predisposition to Disease; Genotype; Genotypes; Hospitals; Humans; IL-1β; Inflammation; Interleukin; Interleukin-1beta - genetics; Interleukins; Iron; Lung diseases; Male; Mining; NLR Family, Pyrin Domain-Containing 3 Protein; Occupational exposure; Occupational Exposure - adverse effects; Odds Ratio; Polymorphism, Single Nucleotide; Population studies; Public health; Pulmonary fibrosis; Regression analysis; Regression models; Risk; Risk Factors; Science; Silica; Silicas; Silicosis; Silicosis - etiology; Silicosis - genetics; Silicosis - pathology; Smoking; Smoking - physiopathology; Statistical analysis; Time Factors; Tumor necrosis factor-TNF; United States > US; China

To evaluate the effects of the interactions between polymorphisms in Nalp3, caspase-1, and interleukin(IL)-1β genes and occupational dust exposure on the risk of silicosis. We conducted a population-based case-control study in a large iron mine in China. Between January 2006 and December 2009, we id...