Interleukin17A Promotes Postoperative Cognitive Dysfunction by Triggering β-Amyloid Accumulation via the Transforming Growth Factor-β (TGFβ)/Smad Signaling Pathway

• Published in: PloS one Vol. 10; no. 10; p. e0141596
• Main Authors: Tian, Ayong, Ma, Hong, Zhang, Rongwei, Tan, Wenfei, Wang, Xiaolong, Wu, Binyang, Wang, Jun, Wan, Chengfu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.10.2015; Public Library of Science (PLoS)
• Subjects: Accumulation; Activation; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - metabolism; Anesthesiology; Animal cognition; Animals; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - pharmacology; Apoptosis; Astrocytes; Astrocytes - metabolism; Biomarkers; Brain research; Cognition Disorders - drug therapy; Cognition Disorders - etiology; Cognition Disorders - metabolism; Cognitive ability; Cytokines; Cytokines - metabolism; Disease Models, Animal; Gene expression; Geriatrics; Growth factors; Hepatectomy; Hepatectomy - adverse effects; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Hospitals; Immunoglobulins; Inflammation; Interleukin 1; Interleukin-17 - antagonists & inhibitors; Interleukin-17 - metabolism; Laboratory animals; Male; Maze Learning; Memory, Short-Term; Mice; Monoclonal antibodies; Nervous system; Older people; Pathogenesis; Peptides; Phosphorylation; Postoperative Complications; Ribonucleic acid; RNA; Rodents; Signal Transduction; Signaling; siRNA; Smad protein; Smad Proteins - metabolism; Smad3 protein; Spatial Memory; Surgery; Transforming growth factor; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Tumor necrosis factor-TNF; β-Amyloid; United States > US; China

Although postoperative cognitive dysfunction (POCD) is relatively common in elderly patients who have undergone major surgery, the mechanisms underlying this postoperative complication are unclear. Previously, we have investigated the role of cytokine-mediated hippocampal inflammation in the develop...