Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women
Aim: To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women. Methods: A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital wer...
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Published in | Acta pharmacologica Sinica Vol. 30; no. 7; pp. 1065 - 1070 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Nature Publishing Group UK
01.07.2009
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Abstract | Aim: To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women.
Methods: A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain.
Results: The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (P〈0.05). No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities (DWMHs) in the control group was significantly higher than that in the HRT group (P=0.0013); however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity (PVH) between the two groups was observed.
Conclusion: We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma. |
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AbstractList | Aim:
To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women.
Methods:
A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate mental state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain.
Results:
The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (
P
<0.05). No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities (DWMHs) in the control group was significantly higher than that in the HRT group (
P
=0.0013); however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity (PVH) between the two groups was observed.
Conclusion:
We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma. Aim:To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women. Methods:A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate mental state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain. Results:The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (P<0.05). No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities (DWMHs) in the control group was significantly higher than that in the HRT group (P=0.0013); however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity (PVH) between the two groups was observed. Conclusion:We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.Acta Pharmacologica Sinica (2009) 30: 1065-1070; doi: 10.1038/aps.2009.81 AIMTo apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women.METHODSA total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate mental state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain.RESULTSThe ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (P<0.05). No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities (DWMHs) in the control group was significantly higher than that in the HRT group (P=0.0013); however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity (PVH) between the two groups was observed.CONCLUSIONWe found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.Acta Pharmacologica Sinica (2009) 30: 1065-1070; doi: 10.1038/aps.2009.81. Aim: To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women. Methods: A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain. Results: The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (P〈0.05). No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities (DWMHs) in the control group was significantly higher than that in the HRT group (P=0.0013); however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity (PVH) between the two groups was observed. Conclusion: We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma. To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women. A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate mental state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain. The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (P<0.05). No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities (DWMHs) in the control group was significantly higher than that in the HRT group (P=0.0013); however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity (PVH) between the two groups was observed. We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.Acta Pharmacologica Sinica (2009) 30: 1065-1070; doi: 10.1038/aps.2009.81. To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women. A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate mental state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain. The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (P<0.05). No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities (DWMHs) in the control group was significantly higher than that in the HRT group (P=0.0013); however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity (PVH) between the two groups was observed. We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.Acta Pharmacologica Sinica (2009) 30: 1065-1070; doi: 10.1038/aps.2009.81. |
Author | Yan-yong LIU Ling HU Chao JI Dong-wen CHEN Xi SHEN Nan YANG Yun YUE Jing-mei JIANG Xia HONG Qin-sheng GE Ping-ping ZUO |
AuthorAffiliation | Department of Pharmacology, School of Basic Medicine, Peking Union Medical College and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China Peking Union Medical College Hospital, Beijing 100730, China |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19575009$$D View this record in MEDLINE/PubMed |
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References | Raz, N, Rodrigue, KM, Kennedy, KM, Acker, JD 2004; 15 Dubas, F, Gray, F, Reullet, E 1985; 141 De Leeuw, FE, Richard, F, de Groot, JC 2004; 35 Shumaker, SA, Legault, C, Kuller, L, Rapp, SR, Thal, L, Lane, DS, Fillit, H 2004; 291 Eberling, JL, Wu, C, Tong-Turnbeaugh, R, Jagust, WJ 2004; 21 Tombaugh, TN, McIntyre, NJ 1992; 40 Folstein, MF, Folstein, SE, McHugh, PR 1975; 12 Longstreth, WT Jr, Manolio, TA, Amold, A 1996; 27 De Leeuw, FE, De Groot, JC, Achten, E 2001; 70 Van den Heuvel, DM, Admiraal-Behloul, F, ten Dam, VH 2004; 63 Raz, N, Gunning-Dixon, F, Head, D, Rodrigue, KM, Williamson, A, Acker, JD 2004; 25 Sullivan, EV, Marsh, L, Pfefferbaum, A 2005; 26 Mu, QW, Xie, JX, Weng, YQ, Wen, ZY 1998; 32 Rovaris, M, Iannucci, G, Cercignani, M, Sormani, MP, De Stefano, N, Gerevini, S, Comi, G, Filippi, M 2003; 227 Zhang, ZX, Hong, X, Zhao, JH, Huang, JB, Wei, J, Wang, JM 1999; 32 Erickson, KI, Colcombe, SJ, Raz, N, Korol, DL, Scalf, P, Webb, A 2005; 26 Eberling, JL, Wu, C, Haan, MN, Mungas, D, Buonocore, M, Jagust, WJ 2003; 24 Zec, RF, Trivedi, MA 2002; 12 Yue, Y, Hu, L, Tian, QJ, Jiang, JM, Dong, YL, Jin, ZY 2007; 28 Ge, QS, Tian, QJ, Tseng, H 2006; 22 Erickson, Colcombe, Raz, Korol, Scalf, Webb (CR5) 2005; 26 Dubas, Gray, Reullet (CR16) 1985; 141 Raz, Rodrigue, Kennedy, Acker (CR4) 2004; 15 Raz, Gunning-Dixon, Head, Rodrigue, Williamson, Acker (CR6) 2004; 25 Eberling, Wu, Tong-Turnbeaugh, Jagust (CR7) 2004; 21 De Leeuw, De Groot, Achten (CR19) 2001; 70 Zhang, Hong, Zhao, Huang, Wei, Wang (CR12) 1999; 32 Folstein, Folstein, McHugh (CR13) 1975; 12 Rovaris, Iannucci, Cercignani, Sormani, De Stefano, Gerevini, Comi, Filippi (CR15) 2003; 227 Eberling, Wu, Haan, Mungas, Buonocore, Jagust (CR3) 2003; 24 Zec, Trivedi (CR2) 2002; 12 Eberling, Wu, Haan, Mungas, Buonocore, Jagust (CR9) 2003; 24 Mu, Xie, Weng, Wen (CR10) 1998; 32 Shumaker, Legault, Kuller, Rapp, Thal, Lane, Fillit (CR1) 2004; 291 De Leeuw, Richard, de Groot (CR17) 2004; 35 Longstreth, Manolio, Amold (CR18) 1996; 27 Ge, Tian, Tseng (CR21) 2006; 22 Van den Heuvel, Admiraal-Behloul, ten Dam (CR20) 2004; 63 Tombaugh, McIntyre (CR14) 1992; 40 Sullivan, Marsh, Pfefferbaum (CR8) 2005; 26 Yue, Hu, Tian, Jiang, Dong, Jin (CR11) 2007; 28 N Raz (BFaps200981_CR4) 2004; 15 FE De Leeuw (BFaps200981_CR17) 2004; 35 Y Yue (BFaps200981_CR11) 2007; 28 SA Shumaker (BFaps200981_CR1) 2004; 291 TN Tombaugh (BFaps200981_CR14) 1992; 40 WTJr Longstreth (BFaps200981_CR18) 1996; 27 DM Van den Heuvel (BFaps200981_CR20) 2004; 63 KI Erickson (BFaps200981_CR5) 2005; 26 JL Eberling (BFaps200981_CR3) 2003; 24 FE De Leeuw (BFaps200981_CR19) 2001; 70 M Rovaris (BFaps200981_CR15) 2003; 227 MF Folstein (BFaps200981_CR13) 1975; 12 QW Mu (BFaps200981_CR10) 1998; 32 JL Eberling (BFaps200981_CR7) 2004; 21 JL Eberling (BFaps200981_CR9) 2003; 24 QS Ge (BFaps200981_CR21) 2006; 22 ZX Zhang (BFaps200981_CR12) 1999; 32 N Raz (BFaps200981_CR6) 2004; 25 RF Zec (BFaps200981_CR2) 2002; 12 F Dubas (BFaps200981_CR16) 1985; 141 EV Sullivan (BFaps200981_CR8) 2005; 26 |
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Snippet | Aim: To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of... Aim: To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of... To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of... Aim:To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of... AIMTo apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of... |
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SubjectTerms | Aged Aged, 80 and over Animals Biomedical and Life Sciences Biomedicine Brain - anatomy & histology Brain - drug effects Brain - metabolism Estradiol - blood Estradiol - pharmacology Female Hormone Replacement Therapy Humans Immunology Internal Medicine Magnetic Resonance Imaging Medical Microbiology Mental Status Schedule Middle Aged Original original-article Pharmacology/Toxicology Vaccine 磁共振成像 绝经后 高密度 |
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Title | Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women |
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