Injectable mesoporous bioactive glass/sodium alginate hydrogel loaded with melatonin for intervertebral disc regeneration

• Published in: Materials today bio Vol. 22; p. 100731
• Main Authors: Wu, Ruibang, Huang, Leizhen, Xia, Qinghong, Liu, Zheng, Huang, Yong, Jiang, Yulin, Wang, Juehan, Ding, Hong, Zhu, Ce, Song, Yueming, Liu, Limin, Zhang, Li, Feng, Ganjun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2023; Elsevier
• Subjects: Full Length; Hydrogel; Intervertebral disc; Mechanical properties; Melatonin; Mechanical properties; Melatonin; Hydrogel; Intervertebral disc

Intervertebral disc degeneration (IDD) is a major contributing factor to both lower back and neck pain. As IDD progresses, the intervertebral disc (IVD) loses its ability to maintain its disc height when subjected to axial loading. This failure in the weight-bearing capacity of the IVD is a characte...