Phosphate-activated glutaminase expression during tumor development

• Published in: FEBS letters Vol. 341; no. 1; pp. 39 - 42
• Main Authors: Aledo, Juan C., Segura, Juan A., Medina, Miguel A., Alonso, Francisco J., de Castro, Ignacio Núñez, Marquez, Javier
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 14.03.1994; Elsevier
• Subjects: Animals; Biological and medical sciences; Blotting, Northern; Carcinoma, Ehrlich Tumor - enzymology; Cell Division; Enzyme Activation; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; General aspects (metabolism, cell proliferation, established cell line...); Glutaminase - biosynthesis; Glutaminase expression; Medical sciences; Mice; Mitochondria - enzymology; PAG, phosphate-activated glutaminase; Phosphates - metabolism; SDS, sodium dodecyl sulphate; Tumor cell; Tumor Cells, Cultured; Tumor development; Tumor glutaminase; Tumors; SDS, sodium dodecyl sulphate; Tumor glutaminase; Glutaminase expression; PAG, phosphate-activated glutaminase; Tumor development; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; Enzyme; Rodentia; Malignant tumor; Gene expression; Cell transformation; Carcinogenesis; In vitro; Glutaminase; Vertebrata; Mitochondria; Mammalia; Enzymatic activity; Mouse; Animal; Hydrolases; Tumor cell

Changes in phosphate-activated glutaminase activities determined in intact cells and isolated mitochondria have been followed during mouse Ehrlich ascites carcinoma development. Glutaminase activities parallel the levels of poly(A) + RNAs encoding for the mitochondrial phosphate activated glutaminas...