The Role of κ Opioid Receptor in Brain Ischemia

• Published in: Critical care medicine Vol. 44; no. 12; p. e1219
• Main Authors: Chen, Chunhua, Xi, Chunhua, Liang, Xuan, Ma, Jingyuan, Su, Diansan, Abel, Ted, Liu, Renyu
• Format: Journal Article
• Language: English
• Published: United States 01.12.2016
• Subjects: Animals; Apoptosis - drug effects; Blotting, Western; Brain Ischemia - drug therapy; Brain Ischemia - metabolism; Brain Ischemia - physiopathology; Disease Models, Animal; Diterpenes, Clerodane - pharmacology; Male; Mice; Mice, Inbred C57BL; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Receptors, Opioid, kappa - agonists; Receptors, Opioid, kappa - antagonists & inhibitors; Receptors, Opioid, kappa - physiology; Reperfusion Injury - prevention & control

Our previous studies indicated that highly selective κ opioid receptor agonists could protect the brain, indicating an important role of κ opioid receptor agonist in brain ischemia. In this study, we investigated the role and related mechanisms of κ opioid receptor agonists in brain ischemia in a mi...