Structure, location and interactions of G‐quadruplexes

• Published in: The FEBS journal Vol. 277; no. 17; pp. 3452 - 3458
• Main Author: Huppert, Julian L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2010
• Subjects: Biochemistry; bioinformatics; biophysics; chemistry; computational biology; Computational mathematics; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - genetics; DNA - metabolism; Experiments; G-Quadruplexes; genetics; Genome; Genome - genetics; Genomics; G‐quadruplex; G‐quartet; G‐tetraplex; human diseases; Humans; metabolism; oncogenes; RNA; Telomere; Telomere - genetics; transcription; translation; translation (genetics)

Four‐stranded G‐rich DNA structures called G‐quadruplexes have been the subject of increasing interest recently. Experimental and computational techniques have been used to implicate them in important biological processes such as transcription and translation. In this minireview, I discuss how they...