Zolmitriptan Nasal Spray in the Acute Treatment of Cluster Headache: A Meta-Analysis of Two Studies

• Published in: Headache Vol. 49; no. 9; pp. 1315 - 1323
• Main Authors: Hedlund, Cecilia, Rapoport, Alan M., Dodick, David W., Goadsby, Peter J.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.10.2009; Wiley-Blackwell
• Subjects: Acute Disease - therapy; acute headache treatment; Adolescent; Adult; Aged; Biological and medical sciences; chronic; Chronic Disease - drug therapy; cluster headache; Cluster Headache - drug therapy; Cross-Over Studies; Dose-Response Relationship, Drug; double-blind; Double-Blind Method; episodic; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Oxazolidinones - administration & dosage; Placebo Effect; Serotonin Receptor Agonists - administration & dosage; Treatment Outcome; Tryptamines - administration & dosage; Vascular diseases and vascular malformations of the nervous system; Young Adult; zolmitriptan; Cluster analysis; Blind; Agonist; Nervous system diseases; episodic; Antimigrainous agent; Zolmitriptan; Tryptamine derivatives; Cardiovascular disease; 5-HT1 Serotonine receptor; Serotonin agonist; acute headache treatment; Cerebral disorder; Vascular disease; Chronic; Cluster headache; Pain; Treatment; Central nervous system disease; Triptan derivatives; Indole derivatives; Cerebrovascular disease; double-blind

Objective.— To conduct an individual subject meta‐analysis of available controlled studies of zolmitriptan nasal spray in the acute treatment of cluster headache. Background.— Two double‐blind, placebo‐controlled, randomized, crossover studies of zolmitriptan nasal spray in the acute treatment of cl...