Study of immunohistochemical expression of insulin-like growth factor I and proliferating cell nuclear antigen in thyroid gland papillary carcinoma and its metastasis
Background Several tumor factors are associated with papillary thyroid cancer. Most studies do not compare the expressions of these factors in the primary tumors and in their associated cervical metastasis. Methods Paraffin sections of 20 patients with papillary carcinoma of the thyroid gland with l...
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Published in | Head & neck Vol. 21; no. 8; pp. 723 - 727 |
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Main Authors | , , , , , , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
New York
John Wiley & Sons, Inc
01.12.1999
John Wiley & Sons |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Several tumor factors are associated with papillary thyroid cancer. Most studies do not compare the expressions of these factors in the primary tumors and in their associated cervical metastasis.
Methods
Paraffin sections of 20 patients with papillary carcinoma of the thyroid gland with lymph node metastasis were studied. The presence and distribution of insulin‐like growth factor I (IGF‐I) and proliferating cell nuclear antigen (PCNA) was analyzed, through immunohistochemical technique, in both primaries and lymph node metastasis. The results were correlated with clinical‐pathologic data (sex, age, size of primary, multicentricity, thyroid capsule invasion, lymphatic and blood vessels invasion, development of distant metastasis, and associated thyroid diseases).
Results
The qualitative analysis showed the reaction for IGF‐I was present in more than 90% of the neoplastic cells in both primaries and lymph node metastasis. No correlation with the clinical‐pathlogical features was observed. Regarding the PCNA, the mean percentage of nuclei stained showed no statistical difference between primaries and metastasis (p = 0.598). Except for age, clinicopathologic data had no influence on the mean percentage of nuclei stained. A correlation was verified between the percentage of cells stained by PCNA in primary tumors and the patients' age (p < 0.01).
Conclusions
The expressions of these tumor factors are equally intense for both primary and metastatic tissue in papillary thyroid cancer. Despite the small size of the sample, the expressions of IGF‐I and PCNA could not be associated to clinical‐pathologic features, except for the age. As patients over 40 years old had higher expression of PCNA, this marker may have prognostic significance for patients with papillary thyroid cancer. © 1999 John Wiley & Sons, Inc. Head Neck 21: 723–727, 1999. |
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Bibliography: | istex:E627EF39F48C589A880CD417CA85419374CC536C ark:/67375/WNG-Z3XBK2PL-W This study was presented at the 43rd Annual Meeting of the Society of Head and Neck Surgeons, in Cancun, Mexico, April 10-12, 1997. ArticleID:HED7 This study was presented at the 43rd Annual Meeting of the Society of Head and Neck Surgeons, in Cancun, Mexico, April 10–12, 1997. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 1043-3074 1097-0347 |
DOI: | 10.1002/(SICI)1097-0347(199912)21:8<723::AID-HED7>3.0.CO;2-6 |