A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS‐986231 in Healthy Volunteers

• Published in: Journal of clinical pharmacology Vol. 59; no. 5; pp. 717 - 730
• Main Authors: Cowart, Douglas, Venuti, Robert P., Lynch, Kim, Guptill, Jeffrey T., Noveck, Robert J., Foo, Shi Yin
• Format: Journal Article
• Language: English
• Published: England 01.05.2019
• Subjects: heart failure; HNO donor; humans; nitroxyl; pharmacokinetics; phase 1; HNO donor; pharmacokinetics; heart failure; nitroxyl; phase 1; humans

Nitroxyl (HNO) is a reactive nitrogen molecule that has potential therapeutic benefits for patients with acute heart failure. The results of the first‐in‐human study for BMS‐986231, a novel HNO donor, are reported. The aim of this sequential cohort study was to evaluate the safety, tolerability, and...