Abuse Potential of Lasmiditan: A Phase 1 Randomized, Placebo‐ and Alprazolam‐Controlled Crossover Study

• Published in: Journal of clinical pharmacology Vol. 60; no. 4; pp. 495 - 504
• Main Authors: Wilbraham, Darren, Berg, Paul H., Tsai, Max, Liffick, Emily, Loo, Li Shen, Doty, Erin Gautier, Sellers, Edward
• Format: Journal Article
• Language: English
• Published: England 01.04.2020
• Subjects: 5HT1F; abuse potential; lasmiditan; migraine; serotonin; abuse potential; serotonin; 5HT1F; migraine; lasmiditan

Lasmiditan is a centrally penetrant, highly selective 5‐hydroxytryptamine (serotonin) receptor 1F (5HT1F) agonist under development as a novel therapy for acute treatment of migraine. A phase 1 randomized, placebo‐ and positive‐controlled crossover study assessed the abuse potential of lasmiditan in...