Consanguinity and endogamy in Northern Tunisia and its impact on non-syndromic deafness

• Published in: Genetic epidemiology Vol. 27; no. 1; pp. 74 - 79
• Main Authors: Ben Arab, Saida, Masmoudi, Saber, Beltaief, Najeh, Hachicha, Slah, Ayadi, Hammadi
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2004; Wiley-Liss
• Subjects: Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Classical genetics, quantitative genetics, hybrids; Consanguinity; Deafness - epidemiology; Deafness - genetics; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Female; Fundamental and applied biological sciences. Psychology; Genetic Predisposition to Disease - epidemiology; Genetic Predisposition to Disease - genetics; Genetics of eukaryotes. Biological and molecular evolution; Geography; hearing loss; Hearing Tests; Human; Humans; inbreeding; Male; Marriage - ethnology; Medical sciences; Models, Genetic; mutation; Mutation - genetics; Non tumoral diseases; Nuclear Family - ethnology; Otorhinolaryngology. Stomatology; Risk; Rural Health; Social Isolation; Tunisia - epidemiology; Tunisia; Africa; Epidemiologic genetics; Auditory disorder; ENT disease; Inbreeding; Risk; Consanguinity; Mutation; Hearing loss

Deafness is an important health problem in the Tunisian population, especially in isolates where the prevalence ranges from 2 to 8%. To evaluate the effect of inbred unions on deafness, a study was conducted on 5,020 individuals (160 are deaf) between 2000 and 2002 in the North of Tunisia. The coeff...