Verteporfin inhibits the persistent fibrotic phenotype of lesional scleroderma dermal fibroblasts

• Published in: Journal of cell communication and signaling Vol. 15; no. 1; pp. 71 - 80
• Main Authors: Shi-wen, Xu, Racanelli, Michael, Ali, Aaisham, Simon, Amara, Quesnel, Katherine, Stratton, Richard J., Leask, Andrew
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.03.2021; John Wiley & Sons, Inc
• Subjects: Actin; Autocrine signalling; Biomedical and Life Sciences; Biomedicine; CCN2; Cell adhesion & migration; Cell Biology; Cell migration; Collagen; Connective tissue growth factor; Contractility; Contraction; CTGF; Extracellular matrix; Fibroblasts; Fibrosis; Gene expression; Genomes; Life Sciences; Mechanotransduction; Myofibroblasr; Phenotypes; Polymerase chain reaction; Research Article; Scleroderma; Skin; Systemic sclerosis; Transcription; Verteporfin; YAP1; Yes-associated protein; YAP1; Myofibroblasr; Fibrosis; Verteporfin; Connective tissue growth factor; Mechanotransduction; CCN2; Scleroderma; CTGF

Fibrosis is perpetuated by an autocrine, pro-adhesive signaling loop maintained by the synthetic and contractile abilities of myofibroblasts and the stiff, highly-crosslinked extracellular matrix. Transcriptional complexes that are exquisitely responsive to mechanotransduction include the co-activat...