Advances in Escherichia coli Nissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies
With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability...
Saved in:
| Published in | Materials today bio Vol. 18; p. 100543 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.02.2023
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2590-0064 2590-0064 |
| DOI | 10.1016/j.mtbio.2023.100543 |
Cover
Loading…
| Abstract | With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Escherichia coli Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment.
[Display omitted] |
|---|---|
| AbstractList | With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Escherichia coli Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment.With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Escherichia coli Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment. With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Escherichia coli Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment. With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment. With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Escherichia coli Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment. Image 1 With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an emerging biomimetic platform that can retain the innate biological functions. Benefiting from its good biocompatibility and ideal targeting ability as a biological carrier, Escherichia coli Nissle 1917 (ECN) has been focused on the treatment strategies of inflammatory bowel disease and tumor. The advantage of a bacterial carrier is that it can express exogenous protein while also acting as a natural capsule by releasing drug slowly as a result of its own colonization impact. In order to survive in harsh environments such as the digestive tract and tumor microenvironment, ECN can be modified or genetically engineered to enhance its function and host adaptability. The adoption of ECN carries or expresses drugs which are essential for accurate diagnosis and treatment. This review briefly describes the properties of ECN, the relationship between ECN and inflammation and tumor, and the strategy of using surface modification and genetic engineering to modify ECN as a delivery carrier for disease treatment. [Display omitted] |
| ArticleNumber | 100543 |
| Author | Qu, Linkai Jin, Libo Li, Hua Sun, Da Ji, Hao Peng, Bo Wu, Wei Chen, Haojie Yang, Qinsi Ma, Jiahui Fang, Yimeng Lei, Pengyu |
| Author_xml | – sequence: 1 givenname: Haojie surname: Chen fullname: Chen, Haojie organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China – sequence: 2 givenname: Pengyu surname: Lei fullname: Lei, Pengyu organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China – sequence: 3 givenname: Hao surname: Ji fullname: Ji, Hao organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China – sequence: 4 givenname: Qinsi surname: Yang fullname: Yang, Qinsi organization: Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China – sequence: 5 givenname: Bo surname: Peng fullname: Peng, Bo organization: Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325000, China – sequence: 6 givenname: Jiahui surname: Ma fullname: Ma, Jiahui organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China – sequence: 7 givenname: Yimeng orcidid: 0000-0002-0859-7011 surname: Fang fullname: Fang, Yimeng organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China – sequence: 8 givenname: Linkai surname: Qu fullname: Qu, Linkai organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China – sequence: 9 givenname: Hua surname: Li fullname: Li, Hua organization: Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, China – sequence: 10 givenname: Wei orcidid: 0000-0003-3900-5135 surname: Wu fullname: Wu, Wei email: david2015@cqu.edu.cn organization: Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400044, China – sequence: 11 givenname: Libo surname: Jin fullname: Jin, Libo email: 20160121@wzu.edu.cn organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China – sequence: 12 givenname: Da orcidid: 0000-0001-7747-9951 surname: Sun fullname: Sun, Da email: sunday@wzu.edu.cn organization: Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36647536$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUsFu1DAQjVARLaVfgIR85LKLY8dOcgCpqgpUquACZ2tij3dnlcTF9q5UDnw73m6pWg5wsv383pux572sjuYwY1W9rvmy5rV-t1lOeaCwFFzIgnDVyGfViVA9X3Cum6NH--PqLKUN51y0fcN5_6I6llo3rZL6pPp17nYwW0yMZnaZ7Boj2TUBs2Ek9oVSGpHVfd0ySKyg25TDRD9hKLCL2xVzONIO4y1LtynjxHyIzFFCSMhyRMgTzpnB7AoKqzkkSizlCBlXhOlV9dzDmPDsfj2tvn-8_HbxeXH99dPVxfn1wiqh8sKD8xZ975u-5YPUSrReFIQDONG1chDQddDX5SRaxcE5rpW0rXaNboUa5Gl1dfB1ATbmJtIE8dYEIHMHhLgyEDPZEQ1o7TsHHbima7zvQbnBSe6FBZAKVfH6cPC62Q4TOlveF2F8Yvr0Zqa1WYWd6buG193e4O29QQw_tpiymShZHEeYMWyTEW0Zj6z7pivUN49rPRT5M8BCkAeCjSGliP6BUnOzT4rZmLukmH1SzCEpRdX_pbKUIVPYN0zjf7TvD1os89oRRpMsYYmQo4g2lw-lf-p_A7HN3YQ |
| CitedBy_id | crossref_primary_10_1039_D4TB02868F crossref_primary_10_1016_j_biomaterials_2025_123163 crossref_primary_10_2147_IJN_S492651 crossref_primary_10_3389_fbioe_2023_1166094 crossref_primary_10_1002_adma_202308728 crossref_primary_10_1002_anie_202414400 crossref_primary_10_1007_s00253_023_12662_6 crossref_primary_10_1080_19490976_2024_2397874 crossref_primary_10_1021_acsami_4c19059 crossref_primary_10_3389_fbioe_2023_1286502 crossref_primary_10_1093_burnst_tkae037 crossref_primary_10_1111_1751_7915_70029 crossref_primary_10_1186_s12951_024_02437_0 crossref_primary_10_1007_s12033_024_01260_0 crossref_primary_10_1002_anie_202310158 crossref_primary_10_1002_smtd_202301385 crossref_primary_10_1002_fbe2_12098 crossref_primary_10_3390_ijms26031058 crossref_primary_10_3389_fcimb_2024_1440742 crossref_primary_10_1002_adtp_202400425 crossref_primary_10_1039_D3TB01805A crossref_primary_10_1002_ange_202414400 crossref_primary_10_1007_s12602_025_10471_z crossref_primary_10_1038_s41587_024_02418_6 crossref_primary_10_3389_fbioe_2023_1278062 crossref_primary_10_1021_acsnano_4c11412 crossref_primary_10_1002_adma_202405331 crossref_primary_10_1002_advs_202305081 crossref_primary_10_1021_acssynbio_4c00466 crossref_primary_10_1021_acs_nanolett_3c02408 crossref_primary_10_1002_ange_202310158 crossref_primary_10_1016_j_carbpol_2024_121983 crossref_primary_10_1002_adfm_202412893 crossref_primary_10_1038_s41467_025_57533_y crossref_primary_10_3390_toxics11060529 crossref_primary_10_1155_cjid_6675676 crossref_primary_10_1016_j_ijbiomac_2023_126000 crossref_primary_10_1038_s41587_024_02429_3 |
| Cites_doi | 10.1016/j.actbio.2021.06.030 10.15403/jgld.2014.1121.244.ecn 10.1128/AEM.00724-19 10.1038/s41401-020-00606-z 10.1021/acsnano.1c09681 10.18632/oncotarget.20486 10.1007/s00011-014-0761-1 10.3748/wjg.v22.i24.5505 10.1016/j.lfs.2022.120330 10.1016/j.bios.2020.112523 10.1016/j.jconrel.2017.10.041 10.1016/j.micinf.2009.08.002 10.1016/j.nantod.2021.101291 10.1126/sciadv.abf0677 10.1038/s41423-021-00760-2 10.1016/j.ijmm.2012.09.004 10.1126/scitranslmed.aau7975 10.1177/1753425910396251 10.1371/journal.pone.0053957 10.1371/journal.pone.0144559 10.1371/journal.pbio.3000334 10.1111/j.1574-6968.2008.01405.x 10.1021/acsnano.1c00135 10.1039/D2FO00226D 10.1016/j.actbio.2022.02.008 10.1002/adma.202007379 10.1126/scirobotics.aar4423 10.1111/1751-7915.13795 10.1111/vco.12529 10.1021/acs.bioconjchem.8b00352 10.1093/femsle/fnw212 10.3389/fbioe.2021.772522 10.5604/17322693.1127882 10.1007/s00253-016-7829-5 10.1016/j.micpath.2021.105381 10.1021/acs.analchem.1c03568 10.1007/s13765-015-0002-5 10.1080/2162402X.2018.1424676 10.1111/j.1348-0421.2000.tb02533.x 10.1073/pnas.1204158109 10.5217/ir.2014.12.4.266 10.1038/s41467-019-11390-8 10.1038/nbt.4222 10.1007/s00394-020-02441-8 10.1111/j.1462-5822.2006.00836.x 10.1016/j.mtbio.2022.100228 10.1016/j.jconrel.2018.08.033 10.1080/03639045.2018.1449855 10.1126/sciadv.abp8798 10.1021/acssynbio.0c00466 10.3390/pharmaceutics13091452 10.7150/thno.36510 10.1371/journal.pone.0120430 10.1038/s41467-019-13727-9 10.1016/j.ijmm.2007.07.016 10.1080/1040841X.2022.2109405 10.1172/jci.insight.125166 10.1371/journal.pone.0001308 10.1371/journal.ppat.1008029 10.1186/s13036-019-0189-9 10.1111/liv.14815 10.1016/j.colsurfb.2020.110818 10.1021/cr500314d 10.1038/s41598-021-97457-3 10.1016/j.mimet.2005.01.007 10.3389/fmicb.2022.819336 10.1016/j.ijmm.2012.11.006 10.1016/j.ijmm.2012.05.002 10.1016/S0378-1097(03)00434-8 10.1007/s40200-020-00511-6 10.1038/s41598-018-31125-x 10.1080/01635581.2015.990570 10.1002/btm2.10219 10.1016/j.actbio.2017.01.011 10.1016/S0168-3659(02)00267-5 10.3390/pharmaceutics13081226 10.7150/thno.21575 10.1002/bit.21897 10.1016/j.mehy.2013.08.035 10.1007/s00253-018-9417-3 10.1007/s12223-010-0027-4 10.3390/pharmaceutics13111892 10.34172/bi.2020.23 10.1126/scitranslmed.aaa3519 10.1016/j.lfs.2020.118296 10.1016/j.resmic.2018.11.001 10.1039/C6TB01165A |
| ContentType | Journal Article |
| Copyright | 2023 The Authors 2023 The Authors. 2023 The Authors 2023 |
| Copyright_xml | – notice: 2023 The Authors – notice: 2023 The Authors. – notice: 2023 The Authors 2023 |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.1016/j.mtbio.2023.100543 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EISSN | 2590-0064 |
| ExternalDocumentID | oai_doaj_org_article_a66f8da8ad484ff9a5dbd30f2caa35e5 PMC9840185 36647536 10_1016_j_mtbio_2023_100543 S2590006423000030 |
| Genre | Journal Article |
| GroupedDBID | 0SF 6I. AAEDW AAFTH AALRI AAXUO ACLIJ AEXQZ AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ EBS EJD FDB GROUPED_DOAJ M41 M~E NCXOZ OK1 ROL RPM SSZ 0R~ 53G AAYWO AAYXX ACVFH ADCNI ADVLN AEUPX AFJKZ AFPUW AIGII AKBMS AKRWK AKYEP APXCP CITATION NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c525t-fadfcef9f4970b36527f2fce0aad2873b2a88a91ad22750add0653c76d46725b3 |
| IEDL.DBID | DOA |
| ISSN | 2590-0064 |
| IngestDate | Wed Aug 27 01:08:03 EDT 2025 Thu Aug 21 18:38:42 EDT 2025 Fri Jul 11 01:51:17 EDT 2025 Thu Jan 02 22:53:13 EST 2025 Thu Apr 24 22:53:36 EDT 2025 Tue Jul 01 03:52:24 EDT 2025 Tue Jul 25 20:56:41 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Surface modification Genetic engineering Drug delivery system E. coli Nissle 1917 |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. 2023 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c525t-fadfcef9f4970b36527f2fce0aad2873b2a88a91ad22750add0653c76d46725b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
| ORCID | 0000-0003-3900-5135 0000-0002-0859-7011 0000-0001-7747-9951 |
| OpenAccessLink | https://doaj.org/article/a66f8da8ad484ff9a5dbd30f2caa35e5 |
| PMID | 36647536 |
| PQID | 2766431948 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_a66f8da8ad484ff9a5dbd30f2caa35e5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9840185 proquest_miscellaneous_2766431948 pubmed_primary_36647536 crossref_primary_10_1016_j_mtbio_2023_100543 crossref_citationtrail_10_1016_j_mtbio_2023_100543 elsevier_sciencedirect_doi_10_1016_j_mtbio_2023_100543 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-02-01 |
| PublicationDateYYYYMMDD | 2023-02-01 |
| PublicationDate_xml | – month: 02 year: 2023 text: 2023-02-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Materials today bio |
| PublicationTitleAlternate | Mater Today Bio |
| PublicationYear | 2023 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Kim, Shin, Park (bib28) 2015; 58 Jiang, Yang, Li, Zhao, Sun, Müller, Wang, Li, Zhang (bib7) 2021; 93 Yang, Yang, Ye, Zhang, Nie, Cheng, Peng, Zhang, Liu, Zhang, Shi (bib57) 2022; 16 Park, Kim, Ham, Choi, Lee, Yeon, Choi, Kim, Kim, Seok (bib82) 2022; 15 Algieri, Garrido-Mesa, Vezza, Rodríguez-Sojo, Rodríguez-Cabezas, Olivares, García, Gálvez, Morón, Rodríguez-Nogales (bib38) 2021; 60 Yu, Kim, Ahn, Moon (bib94) 2019; 4 Stebe-Frick, Ostaff, Stange, Malek, Wehkamp (bib14) 2018; 8 L. Wang, Y. Liao, R. Yang, Z. Zhu, L. Zhang, Z. Wu, X. Sun, An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis, Bioeng. Transl. Med. (n.d.) e10219. Loessner, Leschner, Endmann, Westphal, Wolf, Kochruebe, Miloud, Altenbuchner, Weiss (bib90) 2009; 11 Zhao, Xu, Zhang, Wu, Yang (bib20) 2022; 13 Schultz, Watzl, Oelschlaeger, Rath, Göttl, Lehn, Schölmerich, Linde (bib45) 2005; 61 Kan, Gelfat, Emani, Praveschotinunt, Joshi (bib71) 2021; 10 Maltby, Leatham-Jensen, Gibson, Cohen, Conway (bib31) 2013; 8 Reissbrodt, Hammes, dal Bello, Prager, Fruth, Hantke, Rakin, Starcic-Erjavec, Williams (bib32) 2009; 290 Scaldaferri, Gerardi, Mangiola, Lopetuso, Pizzoferrato, Petito, Papa, Stojanovic, Poscia, Cammarota, Gasbarrini (bib16) 2016; 22 Różańska, Regulska-Ilow, Choroszy-Król, Ilow (bib18) 2014; 68 Cui, Pang, Zhang, Sun, Zhang, Kang, Xue, Pan, Yang, Zhang, Chang, Liu, Zhang, Wang (bib75) 2021; 15 Chen, Zhu, Wang, Lopez, Li, Kumar, Yu, Chen, Cai, Zhang (bib22) 2017; 50 Lin, Mukherjee, Li, Hou, Pan, Liu (bib62) 2021; 7 Duan, March (bib23) 2008; 101 . Pan, Li, Hou, Lin, Wang, Pang, Wang, Liu (bib63) 2021; 33 Paukner, Kohl, Jalava, Lubitz (bib103) 2003; 11 Hove, Nealon, Chan, Boyer, Haberecht, Ryan (bib21) 2022 Guettsches, Loeseke, Zaehringer, Sonnenborn, Enders, Gatermann, Bufe (bib44) 2012; 18 Mahida, Cunliffe (bib37) 2008 Frey, Koskenkorva, Kallio (bib91) 2003; 224 Zhu, Hao, Liu, Borrás-Hidalgo, Zhang (bib101) 2018; 44 Peng, Triplett, Schachterle, Sundin (bib73) 2019; 85 Nzakizwanayo, Kumar, Ogilvie, Patel, Dedi, Macfarlane, Jones (bib88) 2015; 10 Giuseppe, Andrea, Antonella, Enzo, Alfredo (bib15) 2015; 24 Niu, Yang, Fu, Dong, Zhang, Ju (bib26) 2022; 165 Liu, Li, Wang, Ding, Lee, Hu (bib65) 2021; 41 Teng, Liu, Liu, Wu, Dai, Wang, Wang (bib25) 2022; 13 Trebichavsky, Splichal, Rada, Splichalova (bib30) 2010; 68 Wang, Ye, Wang (bib11) 2021; 37 Ukena, Singh, Dringenberg, Engelhardt, Seidler, Hansen, Bleich, Bruder, Franzke, Rogler, Suerbaum, Buer, Gunzer, Westendorf (bib34) 2007; 2 Li, Wang, Liu, Rawding, Bu, Hong, Hu (bib64) 2021; 33 Xie, Zhao, Song, Tang, Mo, Li (bib51) 2017; 268 Fu, Xu (bib72) 2000; 44 Guo, Chen, Ma, Ma, Zhu, Ma, Liu, Wang, Pan (bib42) 2019 Xie, Mo, Cao, Xie, Li, Zhang, Li (bib59) 2022; 142 Zídek, Kmonícková, Kostecká, Tlaskalová-Hogenová (bib47) 2010; 55 Ou, Yang, Tham, Chen, Guo, Zhu (bib69) 2016; 100 He, Yang, Tang, Liu, Chen, Lu, He, Tang, Sun, Liu, Ding, Zhang, Hu, Xia (bib78) 2019; 13 Luo, Wu, Sun, Dai, Wang, Zhong, Wang, Maruf, Nurhidayah, Zhang, Wang, Wang (bib2) 2018; 29 Isabella, Ha, Castillo, Lubkowicz, Rowe, Millet, Anderson, Li, Fisher, West, Reeder, Momin, Bergeron, Guilmain, Miller, Kurtz, Falb (bib107) 2018; 36 Wang, Bastian, Lawrence, Howarth (bib53) 2015; 67 Bazi, Jalili, Hekmatdoost (bib93) 2013; 81 He, Yang, Liu, Chen, Tang, Ji, Tang, Liu, Sun, Hu, Zhang, Liu, Huang, Ding, Xia (bib92) 2017; 8 Ji, Peng, Jin, Ma, Yang, Sun, Wu (bib1) 2021; 13 Zhang, Ji, He, Chen, Ding, Sun, Hu, Yang, Huang, Zhang, Liu, Xia, coil Nissle (bib86) 2018; 8 Takaishi, Matsuki, Nakazawa, Takada, Kado, Asahara, Kamada, Sakuraba, Yajima, Higuchi, Inoue, Ogata, Iwao, Nomoto, Tanaka, Hibi (bib27) 2008; 298 Xie, Zhang, Zhang, Liu, Chen, Li, Li (bib87) 2021; 131 Bär, von koschitzky, roblick, bruch, schulze, sonnenborn, wedel (bib33) 2009; 21 Zhu, Zhong, Wu, Yan, Cao, Mou, Wang, Sun, Wu (bib5) 2022; 14 Cao, Cheng, Wang, Pang, Liu (bib61) 2019; 10 Troge, Scheppach, Schroeder, Rund, Heuner, Wehkamp, Stange, Oelschlaeger (bib12) 2012; 302 Alizadeh, Esmaeili, Omidi (bib54) 2020; 23 Groza, Gehrig, Kudela, Holcmann, Pirker, Dinhof, Schueffl, Sramko, Hoebart, Alioglu, Grusch, Ogris, Lubitz, Keppler, Pashkunova-Martic, Kowol, Sibilia, Berger, Heffeter (bib104) 2018; 7 Zyrek, Cichon, Helms, Enders, Sonnenborn, Schmidt (bib41) 2007; 9 Kunjachan, Ehling, Storm, Kiessling, Lammers (bib49) 2015; 115 Liu, Wang, Heelan, Chen, Li, Hu (bib67) 2022; 8 Alizadeh, Barzegari, Esmaeili, Omidi (bib74) 2020; 10 Woo, Moon, Kim, Kim, Lim, Yeon, Sung, Lee, Lee, Hwang, Lee (bib79) 2020; 168 Massip, Branchu, Bossuet-Greif, Chagneau, Gaillard, Martin, Boury, Sécher, Dubois, Nougayrède, Oswald (bib89) 2019; 15 Rund, Rohde, Sonnenborn, Oelschlaeger (bib105) 2013; 303 S.S.W. Effendi, I.-S. Ng, Prospective and challenges of live bacterial therapeutics from a superhero Escherichia coli Nissle 1917, Crit. Rev. Microbiol. (n.d.). Mawad, Helmy, Shalkami, Kathayat, Rajashekara, coli (bib55) 2018; 102 Sonnenborn (bib70) 2016; 363 Solomon, Desai, Rosenthal, McArthur, Pattison, Pattison, MacDiarmid, Brahmbhatt, Scott (bib97) 2015; 10 Peng, Ji, Jin, Lin, Huang, Xu, Yang, Sun, Wu (bib3) 2020; 2020 Seo, Weibel, Wehkamp, Oelschlaeger (bib76) 2012; 302 Jalava, Hensel, Szostak, Resch, Lubitz (bib99) 2002; 85 Ahn, Kim, Kum, Yun, Han (bib35) 2017; 55 Sonnenborn, Schulze (bib13) 2009; 21 Behrouzi, Mazaheri, Falsafi, Tavassol, Moshiri, Siadat (bib39) 2020; 19 Lubitz, Mayr, Lubitz (bib100) 2009 Zhang, Fu, Zhang, Pan, Zhang, Zhang, Liu (bib50) 2021; 42 Liu, Gai, Chen, Lan, Jiang (bib48) 2021; 13 Cao, Wang, Pang, Cheng, Liu (bib68) 2019; 10 Tuohy, Somarelli, Borst, Eward, Lascelles, Fogle (bib10) 2020; 18 Sha, Xu, Kong, Wei, Liu, Wu (bib40) 2014; 63 Cao, Zhou, Tang, Feng, Ali, Liu, Li (bib84) 2021; 85 Xie, Zhang, Zhang, Liu, Chen, Li, Li (bib102) 2021; 131 Miller, Harrison, D'Andrea, Endsley, Yin, Kodukula, Watson (bib85) 2013; 5 Sabu, Rejo, Kotta, Pramod (bib8) 2018; 287 Sun, Chen, Wang, Ji, Peng, Jin, Wu (bib4) 2019; 9 Xu, Hou, Zhu, Feng, Wang, Pan (bib43) 2022; 292 Kurtz, Millet, Puurunen, Perreault, Charbonneau, Isabella, Kotula, Antipov, Dagon, Denney, Wagner, West, Degar, Brennan, Miller (bib83) 2019; 11 Alapan, Yasa, Schauer, Giltinan, Tabak, Sourjik, Sitti (bib66) 2018; 3 Guo, Xia, Wu, Zhou, Chen, Li (bib6) 2021; 9 Wang, Ghosh, Bongio, Stebbings, Lampe, Jacobs-Lorena (bib95) 2012; 109 Fu-Ming, Na, Jie-Hua, Ming-Bin, Ying, Ying-Mei, Ai-Qing, Liao, Lin-Tao (bib9) 2019; 46 Li, Helbig, Fu, Bian, Herrmann, Baumann, Stewart, Müller, Li, Zips, Zhang (bib52) 2019; 170 Yan, Liu, Zhang, Zhang, Li, Liu, Wu, Chen (bib81) 2021; 18 Kim (bib36) 2014; 12 Schierack, Kleta, Tedin, Babila, Oswald, Oelschlaeger, Hiemann, Paetzold, Wieler, coli Nissle (bib29) 1917; 6 Luo, Song, Yang, Han, Feng, Leng, Chen (bib56) 2020; 189 Danino, Prindle, Kwong, Skalak, Li, Allen, Hasty, Bhatia (bib80) 2015; 7 Vargason, Santhosh, Anselmo (bib60) 2020; 16 Dróżdż, Makuch, Cieniuch, Woźniak, Ziółkowski (bib17) 2020; 261 Steimle, Menz, Bender, Ball, Weber, Hagemann, Lange, Maerz, Parusel, Michaelis, Schäfer, Yao, Löw, Beier, Tesfazgi Mebrhatu, Gronbach, Wagner, Voehringer, Schaller, Fehrenbacher, Autenrieth, Oelschlaeger, Frick (bib46) 2019; 17 Ochoa-Sanchez, Oliveira, Tremblay, Petrazzo, Pant, Bosoi, Perreault, Querbes, Kurtz, Rose (bib106) 2021; 41 Xie, Tai, Song, Luo, Zhang, Li (bib58) 2016; 4 Storm, Koff, Horvath, Li, Justice (bib24) 2011; 186 Chen, Ji, Kong, Lei, Yang, Wu, Jin, Sun (bib98) 2021; 13 Chiang, Hong (bib96) 2021; 11 Yang (10.1016/j.mtbio.2023.100543_bib57) 2022; 16 Frey (10.1016/j.mtbio.2023.100543_bib91) 2003; 224 Isabella (10.1016/j.mtbio.2023.100543_bib107) 2018; 36 Wang (10.1016/j.mtbio.2023.100543_bib11) 2021; 37 Bär (10.1016/j.mtbio.2023.100543_bib33) 2009; 21 Seo (10.1016/j.mtbio.2023.100543_bib76) 2012; 302 Cao (10.1016/j.mtbio.2023.100543_bib61) 2019; 10 Cui (10.1016/j.mtbio.2023.100543_bib75) 2021; 15 Miller (10.1016/j.mtbio.2023.100543_bib85) 2013; 5 Różańska (10.1016/j.mtbio.2023.100543_bib18) 2014; 68 Zhao (10.1016/j.mtbio.2023.100543_bib20) 2022; 13 Algieri (10.1016/j.mtbio.2023.100543_bib38) 2021; 60 Alapan (10.1016/j.mtbio.2023.100543_bib66) 2018; 3 Cao (10.1016/j.mtbio.2023.100543_bib68) 2019; 10 Cao (10.1016/j.mtbio.2023.100543_bib84) 2021; 85 Zhang (10.1016/j.mtbio.2023.100543_bib50) 2021; 42 Giuseppe (10.1016/j.mtbio.2023.100543_bib15) 2015; 24 Pan (10.1016/j.mtbio.2023.100543_bib63) 2021; 33 Zídek (10.1016/j.mtbio.2023.100543_bib47) 2010; 55 Sonnenborn (10.1016/j.mtbio.2023.100543_bib13) 2009; 21 Chen (10.1016/j.mtbio.2023.100543_bib22) 2017; 50 Peng (10.1016/j.mtbio.2023.100543_bib73) 2019; 85 Fu-Ming (10.1016/j.mtbio.2023.100543_bib9) 2019; 46 Ahn (10.1016/j.mtbio.2023.100543_bib35) 2017; 55 Mawad (10.1016/j.mtbio.2023.100543_bib55) 2018; 102 Xie (10.1016/j.mtbio.2023.100543_bib102) 2021; 131 Zhu (10.1016/j.mtbio.2023.100543_bib5) 2022; 14 Peng (10.1016/j.mtbio.2023.100543_bib3) 2020; 2020 10.1016/j.mtbio.2023.100543_bib19 Yu (10.1016/j.mtbio.2023.100543_bib94) 2019; 4 Park (10.1016/j.mtbio.2023.100543_bib82) 2022; 15 Takaishi (10.1016/j.mtbio.2023.100543_bib27) 2008; 298 Kunjachan (10.1016/j.mtbio.2023.100543_bib49) 2015; 115 Danino (10.1016/j.mtbio.2023.100543_bib80) 2015; 7 Ochoa-Sanchez (10.1016/j.mtbio.2023.100543_bib106) 2021; 41 Sun (10.1016/j.mtbio.2023.100543_bib4) 2019; 9 Yan (10.1016/j.mtbio.2023.100543_bib81) 2021; 18 Behrouzi (10.1016/j.mtbio.2023.100543_bib39) 2020; 19 Luo (10.1016/j.mtbio.2023.100543_bib2) 2018; 29 Xie (10.1016/j.mtbio.2023.100543_bib58) 2016; 4 Sonnenborn (10.1016/j.mtbio.2023.100543_bib70) 2016; 363 Schultz (10.1016/j.mtbio.2023.100543_bib45) 2005; 61 Kurtz (10.1016/j.mtbio.2023.100543_bib83) 2019; 11 He (10.1016/j.mtbio.2023.100543_bib92) 2017; 8 Niu (10.1016/j.mtbio.2023.100543_bib26) 2022; 165 Teng (10.1016/j.mtbio.2023.100543_bib25) 2022; 13 Sha (10.1016/j.mtbio.2023.100543_bib40) 2014; 63 Jiang (10.1016/j.mtbio.2023.100543_bib7) 2021; 93 Lin (10.1016/j.mtbio.2023.100543_bib62) 2021; 7 Sabu (10.1016/j.mtbio.2023.100543_bib8) 2018; 287 Xie (10.1016/j.mtbio.2023.100543_bib87) 2021; 131 Solomon (10.1016/j.mtbio.2023.100543_bib97) 2015; 10 Stebe-Frick (10.1016/j.mtbio.2023.100543_bib14) 2018; 8 Liu (10.1016/j.mtbio.2023.100543_bib48) 2021; 13 Ou (10.1016/j.mtbio.2023.100543_bib69) 2016; 100 Groza (10.1016/j.mtbio.2023.100543_bib104) 2018; 7 Luo (10.1016/j.mtbio.2023.100543_bib56) 2020; 189 10.1016/j.mtbio.2023.100543_bib77 Tuohy (10.1016/j.mtbio.2023.100543_bib10) 2020; 18 Ukena (10.1016/j.mtbio.2023.100543_bib34) 2007; 2 Steimle (10.1016/j.mtbio.2023.100543_bib46) 2019; 17 Hove (10.1016/j.mtbio.2023.100543_bib21) 2022 Liu (10.1016/j.mtbio.2023.100543_bib67) 2022; 8 Rund (10.1016/j.mtbio.2023.100543_bib105) 2013; 303 Nzakizwanayo (10.1016/j.mtbio.2023.100543_bib88) 2015; 10 Chen (10.1016/j.mtbio.2023.100543_bib98) 2021; 13 Guo (10.1016/j.mtbio.2023.100543_bib6) 2021; 9 Vargason (10.1016/j.mtbio.2023.100543_bib60) 2020; 16 Kim (10.1016/j.mtbio.2023.100543_bib36) 2014; 12 Bazi (10.1016/j.mtbio.2023.100543_bib93) 2013; 81 Fu (10.1016/j.mtbio.2023.100543_bib72) 2000; 44 Woo (10.1016/j.mtbio.2023.100543_bib79) 2020; 168 Storm (10.1016/j.mtbio.2023.100543_bib24) 2011; 186 Li (10.1016/j.mtbio.2023.100543_bib64) 2021; 33 Schierack (10.1016/j.mtbio.2023.100543_bib29) 1917; 6 Kim (10.1016/j.mtbio.2023.100543_bib28) 2015; 58 Trebichavsky (10.1016/j.mtbio.2023.100543_bib30) 2010; 68 Xu (10.1016/j.mtbio.2023.100543_bib43) 2022; 292 Jalava (10.1016/j.mtbio.2023.100543_bib99) 2002; 85 Guettsches (10.1016/j.mtbio.2023.100543_bib44) 2012; 18 Alizadeh (10.1016/j.mtbio.2023.100543_bib54) 2020; 23 Alizadeh (10.1016/j.mtbio.2023.100543_bib74) 2020; 10 Wang (10.1016/j.mtbio.2023.100543_bib53) 2015; 67 Paukner (10.1016/j.mtbio.2023.100543_bib103) 2003; 11 Troge (10.1016/j.mtbio.2023.100543_bib12) 2012; 302 Wang (10.1016/j.mtbio.2023.100543_bib95) 2012; 109 Reissbrodt (10.1016/j.mtbio.2023.100543_bib32) 2009; 290 Lubitz (10.1016/j.mtbio.2023.100543_bib100) 2009 Dróżdż (10.1016/j.mtbio.2023.100543_bib17) 2020; 261 Massip (10.1016/j.mtbio.2023.100543_bib89) 2019; 15 Guo (10.1016/j.mtbio.2023.100543_bib42) 2019 Xie (10.1016/j.mtbio.2023.100543_bib59) 2022; 142 Li (10.1016/j.mtbio.2023.100543_bib52) 2019; 170 Zhang (10.1016/j.mtbio.2023.100543_bib86) 2018; 8 He (10.1016/j.mtbio.2023.100543_bib78) 2019; 13 Chiang (10.1016/j.mtbio.2023.100543_bib96) 2021; 11 Xie (10.1016/j.mtbio.2023.100543_bib51) 2017; 268 Ji (10.1016/j.mtbio.2023.100543_bib1) 2021; 13 Scaldaferri (10.1016/j.mtbio.2023.100543_bib16) 2016; 22 Duan (10.1016/j.mtbio.2023.100543_bib23) 2008; 101 Zhu (10.1016/j.mtbio.2023.100543_bib101) 2018; 44 Kan (10.1016/j.mtbio.2023.100543_bib71) 2021; 10 Mahida (10.1016/j.mtbio.2023.100543_bib37) 2008 Liu (10.1016/j.mtbio.2023.100543_bib65) 2021; 41 Zyrek (10.1016/j.mtbio.2023.100543_bib41) 2007; 9 Loessner (10.1016/j.mtbio.2023.100543_bib90) 2009; 11 Maltby (10.1016/j.mtbio.2023.100543_bib31) 2013; 8 |
| References_xml | – volume: 6 year: 1917 ident: bib29 article-title: Affects Salmonella adhesion to porcine intestinal epithelial cells publication-title: PLoS One – volume: 168 year: 2020 ident: bib79 article-title: A designed whole-cell biosensor for live diagnosis of gut inflammation through nitrate sensing publication-title: Biosens. Bioelectron. – volume: 102 start-page: 10675 year: 2018 end-page: 10690 ident: bib55 article-title: Nissle microencapsulation in alginate-chitosan nanoparticles and its effect on Campylobacter jejuni publication-title: Appl. Microbiol. Biotechnol. – volume: 18 start-page: 2344 year: 2021 end-page: 2357 ident: bib81 article-title: Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis publication-title: Cell. Mol. Immunol. – volume: 15 year: 2019 ident: bib89 article-title: Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917 publication-title: PLoS Pathog. – volume: 9 year: 2021 ident: bib6 article-title: Research progress on cell membrane-coated biomimetic delivery systems publication-title: Front. Bioeng. Biotechnol. – volume: 101 start-page: 128 year: 2008 end-page: 134 ident: bib23 article-title: Interrupting Vibrio cholerae infection of human epithelial cells with engineered commensal bacterial signaling publication-title: Biotechnol. Bioeng. – volume: 224 start-page: 127 year: 2003 end-page: 132 ident: bib91 article-title: Vitreoscilla hemoglobin promoter is not responsive to nitrosative and oxidative stress in Escherichia coli publication-title: FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett. – volume: 287 start-page: 142 year: 2018 end-page: 155 ident: bib8 article-title: Bioinspired and biomimetic systems for advanced drug and gene delivery publication-title: J. Contr. Release – volume: 5 start-page: 69 year: 2013 end-page: 80 ident: bib85 article-title: β-Carotene biosynthesis in probiotic bacteria, probiotics & antimicro publication-title: Prot. Met. – volume: 115 start-page: 10907 year: 2015 end-page: 10937 ident: bib49 article-title: Noninvasive imaging of nanomedicines and nanotheranostics: principles, progress, and prospects publication-title: Chem. Rev. – volume: 44 start-page: 1328 year: 2018 end-page: 1335 ident: bib101 article-title: Enhanced anti-proliferative efficacy of epothilone B loaded with Escherichia coli Nissle 1917 bacterial ghosts on the HeLa cells by mitochondrial pathway of apoptosis publication-title: Drug Dev. Ind. Pharm. – volume: 11 start-page: 151 year: 2003 end-page: 161 ident: bib103 article-title: Sealed bacterial ghosts--novel targeting vehicles for advanced drug delivery of water-soluble substances publication-title: J. Drug Target. – volume: 186 start-page: 1678 year: 2011 end-page: 1683 ident: bib24 article-title: analysis of the bactericidal activity of Escherichia coli Nissle 1917 against pediatric uropathogens publication-title: J. Urol. – volume: 13 year: 2021 ident: bib98 article-title: Bacterial ghosts-based vaccine and drug delivery systems publication-title: Pharmaceutics – volume: 261 year: 2020 ident: bib17 article-title: Obligate and facultative anaerobic bacteria in targeted cancer therapy: current strategies and clinical applications publication-title: Life Sci. – reference: S.S.W. Effendi, I.-S. Ng, Prospective and challenges of live bacterial therapeutics from a superhero Escherichia coli Nissle 1917, Crit. Rev. Microbiol. (n.d.). – volume: 268 start-page: 390 year: 2017 end-page: 399 ident: bib51 article-title: Doxorubicin-conjugated Escherichia coli Nissle 1917 swimmers to achieve tumor targeting and responsive drug release publication-title: J. Contr. Release – start-page: 1 year: 2022 end-page: 23 ident: bib21 article-title: Integrated profiling of gram-positive and gram-negative probiotic genomes, proteomes and metabolomes revealed small molecules with differential growth inhibition of antimicrobial-resistant pathogens publication-title: J. Diet. Suppl. – volume: 2 start-page: e1308 year: 2007 ident: bib34 article-title: Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity publication-title: PLoS One – volume: 7 year: 2021 ident: bib62 article-title: Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches publication-title: Sci. Adv. – volume: 15 start-page: 7040 year: 2021 end-page: 7052 ident: bib75 article-title: Optotheranostic nanosystem with phone visual diagnosis and optogenetic microbial therapy for ulcerative colitis at-home care publication-title: ACS Nano – volume: 13 start-page: 1452 year: 2021 ident: bib1 article-title: Recent advances in ROS-sensitive nano-formulations for atherosclerosis applications publication-title: Pharmaceutics – volume: 100 start-page: 8693 year: 2016 end-page: 8699 ident: bib69 article-title: Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application publication-title: Appl. Microbiol. Biotechnol. – volume: 303 start-page: 1 year: 2013 end-page: 8 ident: bib105 article-title: Antagonistic effects of probiotic Escherichia coli Nissle 1917 on EHEC strains of serotype O104:H4 and O157:H7 publication-title: International Journal of Medical Microbiology – volume: 14 year: 2022 ident: bib5 article-title: Cell membrane camouflaged biomimetic nanoparticles: focusing on tumor theranostics publication-title: Materials Today Bio – volume: 16 start-page: 4041 year: 2022 end-page: 4058 ident: bib57 article-title: Physiologically inspired mucin coated publication-title: ACS Nano – volume: 61 start-page: 389 year: 2005 end-page: 398 ident: bib45 article-title: Green fluorescent protein for detection of the probiotic microorganism Escherichia coli strain Nissle 1917 (EcN) in vivo publication-title: J. Microbiol. Methods – volume: 8 start-page: 1690 year: 2018 end-page: 1705 ident: bib86 article-title: 1917-Derived minicells for targeted delivery of chemotherapeutic drug to hypoxic regions for cancer therapy publication-title: Theranostics – start-page: 159 year: 2009 end-page: 170 ident: bib100 article-title: Applications of bacterial ghosts in biomedicine publication-title: Pharmaceutical Biotechnology – volume: 8 year: 2018 ident: bib14 article-title: Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue publication-title: Sci. Rep. – volume: 12 start-page: 266 year: 2014 ident: bib36 article-title: Risk factors for delayed recurrence of publication-title: Intest Res – volume: 17 year: 2019 ident: bib46 article-title: Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains publication-title: PLoS Biol. – volume: 165 year: 2022 ident: bib26 article-title: The role of enteric dysbacteriosis and modulation of gut microbiota in the treatment of inflammatory bowel disease publication-title: Microb. Pathog. – volume: 50 start-page: 353 year: 2017 end-page: 360 ident: bib22 article-title: Probiotic E. coli Nissle 1917 biofilms on silicone substrates for bacterial interference against pathogen colonization publication-title: Acta Biomater. – volume: 24 start-page: 499 year: 2015 end-page: 505 ident: bib15 article-title: Escherichia coli Nissle 1917 in ulcerative colitis treatment: systematic review and meta-analysis publication-title: Journal of Gastrointestinal and Liver Diseases : JGLD – volume: 85 year: 2021 ident: bib84 article-title: Genetically encoded probiotic EcN 1917 alleviates alcohol-induced acute liver injury and restore gut microbiota homeostasis publication-title: J. Funct.Foods – volume: 13 start-page: 58 year: 2019 ident: bib78 article-title: Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy publication-title: J. Biol. Eng. – volume: 10 year: 2015 ident: bib97 article-title: A first-time-in-human phase I clinical trial of bispecific antibody-targeted, paclitaxel-packaged bacterial minicells publication-title: PLoS One – volume: 46 start-page: 1162 year: 2019 end-page: 1170 ident: bib9 article-title: Review on cell/bacteria-driven drug delivery systems publication-title: Prog. Biochem. Biophys. – reference: L. Wang, Y. Liao, R. Yang, Z. Zhu, L. Zhang, Z. Wu, X. Sun, An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis, Bioeng. Transl. Med. (n.d.) e10219. – volume: 8 start-page: 85772 year: 2017 end-page: 85782 ident: bib92 article-title: Escherichia coli Nissle 1917 engineered to express Tum-5 can restrain murine melanoma growth publication-title: Oncotarget – volume: 302 start-page: 304 year: 2012 end-page: 314 ident: bib12 article-title: More than a marine propeller – the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus publication-title: International Journal of Medical Microbiology – volume: 9 start-page: 6885 year: 2019 end-page: 6900 ident: bib4 article-title: Advances in refunctionalization of erythrocyte-based nanomedicine for enhancing cancer-targeted drug delivery publication-title: Theranostics – volume: 63 start-page: 873 year: 2014 end-page: 883 ident: bib40 article-title: Preventive effects of Escherichia coli strain Nissle 1917 with different courses and different doses on intestinal inflammation in murine model of colitis publication-title: Inflamm. Res. – volume: 11 year: 2021 ident: bib96 article-title: In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy publication-title: Sci. Rep. – volume: 55 start-page: 181 year: 2010 end-page: 189 ident: bib47 article-title: Decisive role of lipopolysaccharide in activating nitric oxide and cytokine production by the probiotic Escherichia coli strain Nissle 1917 publication-title: Folia Microbiol (Praha) – volume: 10 year: 2015 ident: bib88 article-title: Disruption of Escherichia coli Nissle 1917 K5 capsule biosynthesis, through loss of distinct kfi genes, modulates interaction with intestinal epithelial cells and impact on cell health publication-title: PLoS One – volume: 68 start-page: 1251 year: 2014 end-page: 1256 ident: bib18 article-title: [The role of Escherichia coli strain Nissle 1917 in the gastro-intestinal diseases] publication-title: Postepy Hig. Med. Dosw. – volume: 55 start-page: 830 year: 2017 end-page: 836 ident: bib35 article-title: The synthetic human beta-defensin-3 C15 peptide exhibits antimicrobial activity against Streptococcus mutans, both alone and in combination with dental disinfectants publication-title: J. Microbiol. – volume: 302 start-page: 276 year: 2012 end-page: 287 ident: bib76 article-title: Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins publication-title: Int. J. Med. Microbiol. – volume: 7 year: 2015 ident: bib80 article-title: Programmable probiotics for detection of cancer in urine publication-title: Sci. Transl. Med. – volume: 292 year: 2022 ident: bib43 article-title: The protective effect of Escherichia coli Nissle 1917 on the intestinal barrier is mediated by inhibition of RhoA/ROCK2/MLC signaling via TLR-4 publication-title: Life Sci. – volume: 81 start-page: 961 year: 2013 end-page: 962 ident: bib93 article-title: The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB–IGF-1 hybrid protein publication-title: Med. Hypotheses – volume: 9 start-page: 804 year: 2007 end-page: 816 ident: bib41 article-title: Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKC? redistribution resulting in tight junction and epithelial barrier repair publication-title: Cell Microbiol. – volume: 21 year: 2009 ident: bib33 article-title: Cell-free supernatants of publication-title: Neuro Gastroenterol. Motil. – volume: 363 start-page: fnw212 year: 2016 ident: bib70 article-title: Escherichia coli strain Nissle 1917-from bench to bedside and back: history of a special Escherichia coli strain with probiotic properties publication-title: FEMS Microbiol. Lett. – volume: 44 start-page: 551 year: 2000 end-page: 556 ident: bib72 article-title: Development of a chromosome-plasmid balanced lethal system for publication-title: Microbiol. Immunol. – volume: 22 start-page: 5505 year: 2016 end-page: 5511 ident: bib16 article-title: Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: an update publication-title: World J. Gastroenterol. – volume: 42 start-page: 1040 year: 2021 end-page: 1054 ident: bib50 article-title: Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications publication-title: Acta Pharmacol. Sin. – volume: 41 start-page: 1020 year: 2021 end-page: 1032 ident: bib106 article-title: Genetically engineered publication-title: Liver Int. – volume: 131 start-page: 172 year: 2021 end-page: 184 ident: bib102 article-title: Bacterial navigation for tumor targeting and photothermally-triggered bacterial ghost transformation for spatiotemporal drug release publication-title: Acta Biomater. – volume: 18 start-page: 64 year: 2020 end-page: 75 ident: bib10 article-title: Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-beta and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma publication-title: Vet. Comp. Oncol. – volume: 2020 start-page: 1 year: 2020 end-page: 11 ident: bib3 article-title: Macrophage-based therapies for atherosclerosis management publication-title: Journal of Immunology Research – volume: 13 start-page: 5914 year: 2022 end-page: 5924 ident: bib20 article-title: Probiotic publication-title: Food Funct. – volume: 19 start-page: 597 year: 2020 end-page: 604 ident: bib39 article-title: Intestinal effect of the probiotic Escherichia coli strain Nissle 1917 and its OMV publication-title: J. Diabetes Metab. Disord. – volume: 10 start-page: 94 year: 2021 end-page: 106 ident: bib71 article-title: Plasmid vectors for publication-title: ACS Synth. Biol. – volume: 189 year: 2020 ident: bib56 article-title: Encapsulation of publication-title: Colloids and Surfaces B: Biointerfaces. – volume: 18 start-page: 204 year: 2012 end-page: 216 ident: bib44 article-title: Anti-inflammatory modulation of immune response by probiotic Escherichia coli Nissle 1917 in human blood mononuclear cells publication-title: Innate Immun. – volume: 11 start-page: 1097 year: 2009 end-page: 1105 ident: bib90 article-title: Drug-inducible remote control of gene expression by probiotic Escherichia coli Nissle 1917 in intestine, tumor and gall bladder of mice publication-title: Microb. Infect. – volume: 93 start-page: 15687 year: 2021 end-page: 15695 ident: bib7 article-title: Bacteria-based live vehicle for publication-title: Anal. Chem. – volume: 58 start-page: 45 year: 2015 end-page: 52 ident: bib28 article-title: Fructooligosaccharides decreased the ability of probiotic Escherichia coli Nissle 1917 to adhere to co-cultures of human intestinal cell lines publication-title: J Korean Soc Appl Biol Chem – volume: 13 start-page: 1226 year: 2021 ident: bib48 article-title: Escherichiacoli Nissle 1917 as a novel microrobot for tumor-targeted imaging and therapy publication-title: Pharmaceutics – volume: 85 year: 2019 ident: bib73 article-title: Chromosomally encoded hok-sok toxin-antitoxin system in the fire blight pathogen erwinia amylovora: identification and functional characterization publication-title: Appl. Environ. Microbiol. – volume: 142 start-page: 49 year: 2022 end-page: 59 ident: bib59 article-title: Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic agents publication-title: Acta Biomater. – volume: 8 year: 2013 ident: bib31 article-title: Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157:H7 in the mouse intestine publication-title: PLoS One – volume: 8 year: 2022 ident: bib67 article-title: Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases publication-title: Sci. Adv. – volume: 131 start-page: 172 year: 2021 end-page: 184 ident: bib87 article-title: Bacterial navigation for tumor targeting and photothermally-triggered bacterial ghost transformation for spatiotemporal drug release publication-title: Acta Biomater. – volume: 16 year: 2020 ident: bib60 article-title: Surface modifications for improved delivery and function of therapeutic bacteria publication-title: Small – volume: 4 year: 2019 ident: bib94 article-title: Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF publication-title: JCI Insight – volume: 33 year: 2021 ident: bib63 article-title: Polymerization-mediated multifunctionalization of living cells for enhanced cell-based therapy publication-title: Adv Mater – volume: 21 start-page: 122 year: 2009 end-page: 158 ident: bib13 article-title: The non-pathogenic publication-title: Microb. Ecol. Health Dis. – volume: 41 year: 2021 ident: bib65 article-title: Biomaterials coating for on-demand bacteria delivery: selective release, adhesion, and detachment publication-title: Nano Today – volume: 298 start-page: 463 year: 2008 end-page: 472 ident: bib27 article-title: Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease publication-title: International Journal of Medical Microbiology – volume: 10 start-page: 187 year: 2020 end-page: 193 ident: bib74 article-title: Designing a light-activated recombinant alpha hemolysin for colorectal cancer targeting publication-title: Bioimpacts – volume: 23 start-page: 886 year: 2020 end-page: 893 ident: bib54 article-title: Anti-cancer properties of Escherichia coli Nissle 1917 against HT-29 colon cancer cells through regulation of Bax/Bcl-xL and AKT/PTEN signaling pathways publication-title: Iran J Basic Med Sci – volume: 13 year: 2022 ident: bib25 article-title: Probiotic Escherichia coli Nissle 1917 expressing elafin protects against inflammation and restores the gut microbiota publication-title: Front. Microbiol. – volume: 290 start-page: 62 year: 2009 end-page: 69 ident: bib32 article-title: Inhibition of growth of Shiga toxin-producing publication-title: FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett. – volume: 10 start-page: 5783 year: 2019 ident: bib68 article-title: Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment publication-title: Nat. Commun. – volume: 29 start-page: 2936 year: 2018 end-page: 2944 ident: bib2 article-title: Acid-activated melittin for targeted and safe antitumor therapy publication-title: Bioconjugate Chem. – volume: 68 start-page: 459 year: 2010 end-page: 464 ident: bib30 article-title: Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917 publication-title: Nutrition Reviews©, Vol. 68, No. 8, Nutrition Reviews – volume: 109 start-page: 12734 year: 2012 end-page: 12739 ident: bib95 article-title: Fighting malaria with engineered symbiotic bacteria from vector mosquitoes publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 4 start-page: 6820 year: 2016 end-page: 6829 ident: bib58 article-title: Genetically engineering of Escherichia coli and immobilization on electrospun fibers for drug delivery purposes publication-title: J. Mater. Chem. B. – volume: 85 start-page: 17 year: 2002 end-page: 25 ident: bib99 article-title: Bacterial ghosts as vaccine candidates for veterinary applications publication-title: J. Contr. Release – volume: 170 start-page: 74 year: 2019 end-page: 79 ident: bib52 article-title: Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy publication-title: Res. Microbiol. – volume: 37 start-page: 20 year: 2021 end-page: 28 ident: bib11 article-title: Application of synthetic biology in targeted cancer therapies by E.coli Nissle 1917 publication-title: Chinese Journal of Biochemistry and Molecular Biology – volume: 3 start-page: eaar4423 year: 2018 ident: bib66 article-title: Soft erythrocyte-based bacterial microswimmers for cargo delivery publication-title: Sci. Robot. – volume: 11 year: 2019 ident: bib83 article-title: An engineered publication-title: Sci. Transl. Med. – volume: 10 start-page: 3452 year: 2019 ident: bib61 article-title: Camouflaging bacteria by wrapping with cell membranes publication-title: Nat. Commun. – start-page: 71 year: 2008 end-page: 84 ident: bib37 publication-title: Defensins and Mucosal Protection – volume: 15 start-page: 832 year: 2022 end-page: 843 ident: bib82 article-title: Physiological activity of publication-title: Microb. Biotechnol. – volume: 33 year: 2021 ident: bib64 article-title: Chemically and biologically engineered bacteria-based delivery systems for emerging diagnosis and advanced therapy publication-title: Adv. Mater. – start-page: 1 year: 2019 end-page: 13 ident: bib42 article-title: Escherichia coli Nissle 1917 protects intestinal barrier function by inhibiting NF- publication-title: Mediat. Inflamm. – volume: 36 start-page: 857 year: 2018 end-page: 864 ident: bib107 article-title: Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria publication-title: Nat. Biotechnol. – volume: 67 start-page: 316 year: 2015 end-page: 326 ident: bib53 article-title: Factors derived from publication-title: Nutr. Cancer – reference: . – volume: 7 year: 2018 ident: bib104 article-title: Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis publication-title: OncoImmunology – volume: 60 start-page: 2537 year: 2021 end-page: 2551 ident: bib38 article-title: Intestinal anti-inflammatory effects of probiotics in DNBS-colitis via modulation of gut microbiota and microRNAs publication-title: Eur. J. Nutr. – volume: 131 start-page: 172 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib87 article-title: Bacterial navigation for tumor targeting and photothermally-triggered bacterial ghost transformation for spatiotemporal drug release publication-title: Acta Biomater. doi: 10.1016/j.actbio.2021.06.030 – volume: 24 start-page: 499 year: 2015 ident: 10.1016/j.mtbio.2023.100543_bib15 article-title: Escherichia coli Nissle 1917 in ulcerative colitis treatment: systematic review and meta-analysis publication-title: Journal of Gastrointestinal and Liver Diseases : JGLD doi: 10.15403/jgld.2014.1121.244.ecn – start-page: 1 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib21 article-title: Integrated profiling of gram-positive and gram-negative probiotic genomes, proteomes and metabolomes revealed small molecules with differential growth inhibition of antimicrobial-resistant pathogens publication-title: J. Diet. Suppl. – volume: 55 start-page: 830 year: 2017 ident: 10.1016/j.mtbio.2023.100543_bib35 article-title: The synthetic human beta-defensin-3 C15 peptide exhibits antimicrobial activity against Streptococcus mutans, both alone and in combination with dental disinfectants publication-title: J. Microbiol. – volume: 85 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib73 article-title: Chromosomally encoded hok-sok toxin-antitoxin system in the fire blight pathogen erwinia amylovora: identification and functional characterization publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.00724-19 – volume: 23 start-page: 886 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib54 article-title: Anti-cancer properties of Escherichia coli Nissle 1917 against HT-29 colon cancer cells through regulation of Bax/Bcl-xL and AKT/PTEN signaling pathways publication-title: Iran J Basic Med Sci – start-page: 159 year: 2009 ident: 10.1016/j.mtbio.2023.100543_bib100 article-title: Applications of bacterial ghosts in biomedicine – volume: 42 start-page: 1040 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib50 article-title: Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-020-00606-z – volume: 16 start-page: 4041 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib57 article-title: Physiologically inspired mucin coated Escherichia coli Nissle 1917 enhances biotherapy by regulating the pathological microenvironment to improve intestinal colonization publication-title: ACS Nano doi: 10.1021/acsnano.1c09681 – volume: 8 start-page: 85772 year: 2017 ident: 10.1016/j.mtbio.2023.100543_bib92 article-title: Escherichia coli Nissle 1917 engineered to express Tum-5 can restrain murine melanoma growth publication-title: Oncotarget doi: 10.18632/oncotarget.20486 – volume: 63 start-page: 873 year: 2014 ident: 10.1016/j.mtbio.2023.100543_bib40 article-title: Preventive effects of Escherichia coli strain Nissle 1917 with different courses and different doses on intestinal inflammation in murine model of colitis publication-title: Inflamm. Res. doi: 10.1007/s00011-014-0761-1 – volume: 85 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib84 article-title: Genetically encoded probiotic EcN 1917 alleviates alcohol-induced acute liver injury and restore gut microbiota homeostasis publication-title: J. Funct.Foods – volume: 22 start-page: 5505 year: 2016 ident: 10.1016/j.mtbio.2023.100543_bib16 article-title: Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: an update publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v22.i24.5505 – volume: 292 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib43 article-title: The protective effect of Escherichia coli Nissle 1917 on the intestinal barrier is mediated by inhibition of RhoA/ROCK2/MLC signaling via TLR-4 publication-title: Life Sci. doi: 10.1016/j.lfs.2022.120330 – volume: 21 start-page: 122 year: 2009 ident: 10.1016/j.mtbio.2023.100543_bib13 article-title: The non-pathogenic Escherichia coli strain Nissle 1917 – features of a versatile probiotic publication-title: Microb. Ecol. Health Dis. – volume: 68 start-page: 459 year: 2010 ident: 10.1016/j.mtbio.2023.100543_bib30 article-title: Modulation of natural immunity in the gut by Escherichia coli strain Nissle 1917 publication-title: Nutrition Reviews©, Vol. 68, No. 8, Nutrition Reviews – volume: 168 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib79 article-title: A designed whole-cell biosensor for live diagnosis of gut inflammation through nitrate sensing publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2020.112523 – volume: 268 start-page: 390 year: 2017 ident: 10.1016/j.mtbio.2023.100543_bib51 article-title: Doxorubicin-conjugated Escherichia coli Nissle 1917 swimmers to achieve tumor targeting and responsive drug release publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2017.10.041 – volume: 11 start-page: 1097 year: 2009 ident: 10.1016/j.mtbio.2023.100543_bib90 article-title: Drug-inducible remote control of gene expression by probiotic Escherichia coli Nissle 1917 in intestine, tumor and gall bladder of mice publication-title: Microb. Infect. doi: 10.1016/j.micinf.2009.08.002 – volume: 41 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib65 article-title: Biomaterials coating for on-demand bacteria delivery: selective release, adhesion, and detachment publication-title: Nano Today doi: 10.1016/j.nantod.2021.101291 – volume: 7 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib62 article-title: Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches publication-title: Sci. Adv. doi: 10.1126/sciadv.abf0677 – volume: 18 start-page: 2344 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib81 article-title: Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis publication-title: Cell. Mol. Immunol. doi: 10.1038/s41423-021-00760-2 – volume: 302 start-page: 304 year: 2012 ident: 10.1016/j.mtbio.2023.100543_bib12 article-title: More than a marine propeller – the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus publication-title: International Journal of Medical Microbiology doi: 10.1016/j.ijmm.2012.09.004 – volume: 5 start-page: 69 year: 2013 ident: 10.1016/j.mtbio.2023.100543_bib85 article-title: β-Carotene biosynthesis in probiotic bacteria, probiotics & antimicro publication-title: Prot. Met. – volume: 11 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib83 article-title: An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aau7975 – volume: 18 start-page: 204 year: 2012 ident: 10.1016/j.mtbio.2023.100543_bib44 article-title: Anti-inflammatory modulation of immune response by probiotic Escherichia coli Nissle 1917 in human blood mononuclear cells publication-title: Innate Immun. doi: 10.1177/1753425910396251 – volume: 8 year: 2013 ident: 10.1016/j.mtbio.2023.100543_bib31 article-title: Nutritional basis for colonization resistance by human commensal Escherichia coli strains HS and Nissle 1917 against E. coli O157:H7 in the mouse intestine publication-title: PLoS One doi: 10.1371/journal.pone.0053957 – volume: 10 year: 2015 ident: 10.1016/j.mtbio.2023.100543_bib97 article-title: A first-time-in-human phase I clinical trial of bispecific antibody-targeted, paclitaxel-packaged bacterial minicells publication-title: PLoS One doi: 10.1371/journal.pone.0144559 – volume: 17 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib46 article-title: Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000334 – volume: 2020 start-page: 1 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib3 article-title: Macrophage-based therapies for atherosclerosis management publication-title: Journal of Immunology Research – volume: 290 start-page: 62 year: 2009 ident: 10.1016/j.mtbio.2023.100543_bib32 article-title: Inhibition of growth of Shiga toxin-producing Escherichia coli by nonpathogenic Escherichia coli publication-title: FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett. doi: 10.1111/j.1574-6968.2008.01405.x – volume: 16 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib60 article-title: Surface modifications for improved delivery and function of therapeutic bacteria publication-title: Small – volume: 15 start-page: 7040 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib75 article-title: Optotheranostic nanosystem with phone visual diagnosis and optogenetic microbial therapy for ulcerative colitis at-home care publication-title: ACS Nano doi: 10.1021/acsnano.1c00135 – volume: 13 start-page: 5914 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib20 article-title: Probiotic Escherichia coli NISSLE 1917 for inflammatory bowel disease applications publication-title: Food Funct. doi: 10.1039/D2FO00226D – volume: 142 start-page: 49 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib59 article-title: Bacteria-propelled microtubular motors for efficient penetration and targeting delivery of thrombolytic agents publication-title: Acta Biomater. doi: 10.1016/j.actbio.2022.02.008 – volume: 33 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib63 article-title: Polymerization-mediated multifunctionalization of living cells for enhanced cell-based therapy publication-title: Adv Mater doi: 10.1002/adma.202007379 – volume: 3 start-page: eaar4423 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib66 article-title: Soft erythrocyte-based bacterial microswimmers for cargo delivery publication-title: Sci. Robot. doi: 10.1126/scirobotics.aar4423 – volume: 15 start-page: 832 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib82 article-title: Physiological activity of E. coli engineered to produce butyric acid publication-title: Microb. Biotechnol. doi: 10.1111/1751-7915.13795 – volume: 18 start-page: 64 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib10 article-title: Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-beta and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma publication-title: Vet. Comp. Oncol. doi: 10.1111/vco.12529 – volume: 29 start-page: 2936 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib2 article-title: Acid-activated melittin for targeted and safe antitumor therapy publication-title: Bioconjugate Chem. doi: 10.1021/acs.bioconjchem.8b00352 – volume: 363 start-page: fnw212 year: 2016 ident: 10.1016/j.mtbio.2023.100543_bib70 article-title: Escherichia coli strain Nissle 1917-from bench to bedside and back: history of a special Escherichia coli strain with probiotic properties publication-title: FEMS Microbiol. Lett. doi: 10.1093/femsle/fnw212 – volume: 9 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib6 article-title: Research progress on cell membrane-coated biomimetic delivery systems publication-title: Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2021.772522 – volume: 68 start-page: 1251 year: 2014 ident: 10.1016/j.mtbio.2023.100543_bib18 article-title: [The role of Escherichia coli strain Nissle 1917 in the gastro-intestinal diseases] publication-title: Postepy Hig. Med. Dosw. doi: 10.5604/17322693.1127882 – volume: 100 start-page: 8693 year: 2016 ident: 10.1016/j.mtbio.2023.100543_bib69 article-title: Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application publication-title: Appl. Microbiol. Biotechnol. doi: 10.1007/s00253-016-7829-5 – volume: 165 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib26 article-title: The role of enteric dysbacteriosis and modulation of gut microbiota in the treatment of inflammatory bowel disease publication-title: Microb. Pathog. doi: 10.1016/j.micpath.2021.105381 – volume: 93 start-page: 15687 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib7 article-title: Bacteria-based live vehicle for in vivo bioluminescence imaging publication-title: Anal. Chem. doi: 10.1021/acs.analchem.1c03568 – volume: 33 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib64 article-title: Chemically and biologically engineered bacteria-based delivery systems for emerging diagnosis and advanced therapy publication-title: Adv. Mater. – volume: 58 start-page: 45 year: 2015 ident: 10.1016/j.mtbio.2023.100543_bib28 article-title: Fructooligosaccharides decreased the ability of probiotic Escherichia coli Nissle 1917 to adhere to co-cultures of human intestinal cell lines publication-title: J Korean Soc Appl Biol Chem doi: 10.1007/s13765-015-0002-5 – volume: 7 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib104 article-title: Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis publication-title: OncoImmunology doi: 10.1080/2162402X.2018.1424676 – volume: 44 start-page: 551 year: 2000 ident: 10.1016/j.mtbio.2023.100543_bib72 article-title: Development of a chromosome-plasmid balanced lethal system for Lactobacillus acidophilus with thyA gene as selective marker publication-title: Microbiol. Immunol. doi: 10.1111/j.1348-0421.2000.tb02533.x – volume: 109 start-page: 12734 year: 2012 ident: 10.1016/j.mtbio.2023.100543_bib95 article-title: Fighting malaria with engineered symbiotic bacteria from vector mosquitoes publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1204158109 – volume: 12 start-page: 266 year: 2014 ident: 10.1016/j.mtbio.2023.100543_bib36 article-title: Risk factors for delayed recurrence of Clostridium difficile infection publication-title: Intest Res doi: 10.5217/ir.2014.12.4.266 – start-page: 71 year: 2008 ident: 10.1016/j.mtbio.2023.100543_bib37 – volume: 10 start-page: 3452 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib61 article-title: Camouflaging bacteria by wrapping with cell membranes publication-title: Nat. Commun. doi: 10.1038/s41467-019-11390-8 – volume: 36 start-page: 857 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib107 article-title: Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4222 – volume: 60 start-page: 2537 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib38 article-title: Intestinal anti-inflammatory effects of probiotics in DNBS-colitis via modulation of gut microbiota and microRNAs publication-title: Eur. J. Nutr. doi: 10.1007/s00394-020-02441-8 – volume: 46 start-page: 1162 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib9 article-title: Review on cell/bacteria-driven drug delivery systems publication-title: Prog. Biochem. Biophys. – volume: 9 start-page: 804 year: 2007 ident: 10.1016/j.mtbio.2023.100543_bib41 article-title: Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKC? redistribution resulting in tight junction and epithelial barrier repair publication-title: Cell Microbiol. doi: 10.1111/j.1462-5822.2006.00836.x – volume: 14 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib5 article-title: Cell membrane camouflaged biomimetic nanoparticles: focusing on tumor theranostics publication-title: Materials Today Bio doi: 10.1016/j.mtbio.2022.100228 – volume: 287 start-page: 142 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib8 article-title: Bioinspired and biomimetic systems for advanced drug and gene delivery publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2018.08.033 – volume: 44 start-page: 1328 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib101 article-title: Enhanced anti-proliferative efficacy of epothilone B loaded with Escherichia coli Nissle 1917 bacterial ghosts on the HeLa cells by mitochondrial pathway of apoptosis publication-title: Drug Dev. Ind. Pharm. doi: 10.1080/03639045.2018.1449855 – volume: 8 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib67 article-title: Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases publication-title: Sci. Adv. doi: 10.1126/sciadv.abp8798 – volume: 10 start-page: 94 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib71 article-title: Plasmid vectors for in vivo selection-free use with the probiotic E. coli Nissle 1917 publication-title: ACS Synth. Biol. doi: 10.1021/acssynbio.0c00466 – volume: 13 start-page: 1452 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib1 article-title: Recent advances in ROS-sensitive nano-formulations for atherosclerosis applications publication-title: Pharmaceutics doi: 10.3390/pharmaceutics13091452 – volume: 9 start-page: 6885 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib4 article-title: Advances in refunctionalization of erythrocyte-based nanomedicine for enhancing cancer-targeted drug delivery publication-title: Theranostics doi: 10.7150/thno.36510 – volume: 37 start-page: 20 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib11 article-title: Application of synthetic biology in targeted cancer therapies by E.coli Nissle 1917 publication-title: Chinese Journal of Biochemistry and Molecular Biology – volume: 10 year: 2015 ident: 10.1016/j.mtbio.2023.100543_bib88 article-title: Disruption of Escherichia coli Nissle 1917 K5 capsule biosynthesis, through loss of distinct kfi genes, modulates interaction with intestinal epithelial cells and impact on cell health publication-title: PLoS One doi: 10.1371/journal.pone.0120430 – volume: 10 start-page: 5783 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib68 article-title: Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment publication-title: Nat. Commun. doi: 10.1038/s41467-019-13727-9 – volume: 298 start-page: 463 year: 2008 ident: 10.1016/j.mtbio.2023.100543_bib27 article-title: Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease publication-title: International Journal of Medical Microbiology doi: 10.1016/j.ijmm.2007.07.016 – ident: 10.1016/j.mtbio.2023.100543_bib19 doi: 10.1080/1040841X.2022.2109405 – volume: 4 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib94 article-title: Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF publication-title: JCI Insight doi: 10.1172/jci.insight.125166 – volume: 2 start-page: e1308 year: 2007 ident: 10.1016/j.mtbio.2023.100543_bib34 article-title: Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity publication-title: PLoS One doi: 10.1371/journal.pone.0001308 – volume: 15 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib89 article-title: Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917 publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1008029 – volume: 13 start-page: 58 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib78 article-title: Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy publication-title: J. Biol. Eng. doi: 10.1186/s13036-019-0189-9 – volume: 41 start-page: 1020 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib106 article-title: Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile-duct ligated rats publication-title: Liver Int. doi: 10.1111/liv.14815 – volume: 189 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib56 article-title: Encapsulation of Escherichia coli strain Nissle 1917 in a chitosan―alginate matrix by combining layer-by-layer assembly with CaCl2 cross-linking for an effective treatment of inflammatory bowel diseases publication-title: Colloids and Surfaces B: Biointerfaces. doi: 10.1016/j.colsurfb.2020.110818 – volume: 11 start-page: 151 year: 2003 ident: 10.1016/j.mtbio.2023.100543_bib103 article-title: Sealed bacterial ghosts--novel targeting vehicles for advanced drug delivery of water-soluble substances publication-title: J. Drug Target. – volume: 115 start-page: 10907 year: 2015 ident: 10.1016/j.mtbio.2023.100543_bib49 article-title: Noninvasive imaging of nanomedicines and nanotheranostics: principles, progress, and prospects publication-title: Chem. Rev. doi: 10.1021/cr500314d – volume: 11 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib96 article-title: In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy publication-title: Sci. Rep. doi: 10.1038/s41598-021-97457-3 – volume: 61 start-page: 389 year: 2005 ident: 10.1016/j.mtbio.2023.100543_bib45 article-title: Green fluorescent protein for detection of the probiotic microorganism Escherichia coli strain Nissle 1917 (EcN) in vivo publication-title: J. Microbiol. Methods doi: 10.1016/j.mimet.2005.01.007 – volume: 13 year: 2022 ident: 10.1016/j.mtbio.2023.100543_bib25 article-title: Probiotic Escherichia coli Nissle 1917 expressing elafin protects against inflammation and restores the gut microbiota publication-title: Front. Microbiol. doi: 10.3389/fmicb.2022.819336 – start-page: 1 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib42 article-title: Escherichia coli Nissle 1917 protects intestinal barrier function by inhibiting NF- κ B-mediated activation of the MLCK-P-MLC signaling pathway publication-title: Mediat. Inflamm. – volume: 303 start-page: 1 year: 2013 ident: 10.1016/j.mtbio.2023.100543_bib105 article-title: Antagonistic effects of probiotic Escherichia coli Nissle 1917 on EHEC strains of serotype O104:H4 and O157:H7 publication-title: International Journal of Medical Microbiology doi: 10.1016/j.ijmm.2012.11.006 – volume: 302 start-page: 276 year: 2012 ident: 10.1016/j.mtbio.2023.100543_bib76 article-title: Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins publication-title: Int. J. Med. Microbiol. doi: 10.1016/j.ijmm.2012.05.002 – volume: 224 start-page: 127 year: 2003 ident: 10.1016/j.mtbio.2023.100543_bib91 article-title: Vitreoscilla hemoglobin promoter is not responsive to nitrosative and oxidative stress in Escherichia coli publication-title: FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett. doi: 10.1016/S0378-1097(03)00434-8 – volume: 131 start-page: 172 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib102 article-title: Bacterial navigation for tumor targeting and photothermally-triggered bacterial ghost transformation for spatiotemporal drug release publication-title: Acta Biomater. doi: 10.1016/j.actbio.2021.06.030 – volume: 19 start-page: 597 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib39 article-title: Intestinal effect of the probiotic Escherichia coli strain Nissle 1917 and its OMV publication-title: J. Diabetes Metab. Disord. doi: 10.1007/s40200-020-00511-6 – volume: 8 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib14 article-title: Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue publication-title: Sci. Rep. doi: 10.1038/s41598-018-31125-x – volume: 67 start-page: 316 year: 2015 ident: 10.1016/j.mtbio.2023.100543_bib53 article-title: Factors derived from Escherichia coli Nissle 1917, grown in different growth media, enhance cell death in a model of 5-fluorouracil-induced Caco-2 intestinal epithelial cell damage publication-title: Nutr. Cancer doi: 10.1080/01635581.2015.990570 – ident: 10.1016/j.mtbio.2023.100543_bib77 doi: 10.1002/btm2.10219 – volume: 50 start-page: 353 year: 2017 ident: 10.1016/j.mtbio.2023.100543_bib22 article-title: Probiotic E. coli Nissle 1917 biofilms on silicone substrates for bacterial interference against pathogen colonization publication-title: Acta Biomater. doi: 10.1016/j.actbio.2017.01.011 – volume: 85 start-page: 17 year: 2002 ident: 10.1016/j.mtbio.2023.100543_bib99 article-title: Bacterial ghosts as vaccine candidates for veterinary applications publication-title: J. Contr. Release doi: 10.1016/S0168-3659(02)00267-5 – volume: 13 start-page: 1226 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib48 article-title: Escherichiacoli Nissle 1917 as a novel microrobot for tumor-targeted imaging and therapy publication-title: Pharmaceutics doi: 10.3390/pharmaceutics13081226 – volume: 8 start-page: 1690 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib86 article-title: 1917-Derived minicells for targeted delivery of chemotherapeutic drug to hypoxic regions for cancer therapy publication-title: Theranostics doi: 10.7150/thno.21575 – volume: 101 start-page: 128 year: 2008 ident: 10.1016/j.mtbio.2023.100543_bib23 article-title: Interrupting Vibrio cholerae infection of human epithelial cells with engineered commensal bacterial signaling publication-title: Biotechnol. Bioeng. doi: 10.1002/bit.21897 – volume: 186 start-page: 1678 year: 2011 ident: 10.1016/j.mtbio.2023.100543_bib24 article-title: In vitro analysis of the bactericidal activity of Escherichia coli Nissle 1917 against pediatric uropathogens publication-title: J. Urol. – volume: 81 start-page: 961 year: 2013 ident: 10.1016/j.mtbio.2023.100543_bib93 article-title: The long term oral regulation of blood glucose in diabetic patients by using of Escherichia coli Nissle 1917 expressing CTB–IGF-1 hybrid protein publication-title: Med. Hypotheses doi: 10.1016/j.mehy.2013.08.035 – volume: 102 start-page: 10675 year: 2018 ident: 10.1016/j.mtbio.2023.100543_bib55 article-title: Nissle microencapsulation in alginate-chitosan nanoparticles and its effect on Campylobacter jejuni in vitro publication-title: Appl. Microbiol. Biotechnol. doi: 10.1007/s00253-018-9417-3 – volume: 55 start-page: 181 year: 2010 ident: 10.1016/j.mtbio.2023.100543_bib47 article-title: Decisive role of lipopolysaccharide in activating nitric oxide and cytokine production by the probiotic Escherichia coli strain Nissle 1917 publication-title: Folia Microbiol (Praha) doi: 10.1007/s12223-010-0027-4 – volume: 13 year: 2021 ident: 10.1016/j.mtbio.2023.100543_bib98 article-title: Bacterial ghosts-based vaccine and drug delivery systems publication-title: Pharmaceutics doi: 10.3390/pharmaceutics13111892 – volume: 10 start-page: 187 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib74 article-title: Designing a light-activated recombinant alpha hemolysin for colorectal cancer targeting publication-title: Bioimpacts doi: 10.34172/bi.2020.23 – volume: 7 year: 2015 ident: 10.1016/j.mtbio.2023.100543_bib80 article-title: Programmable probiotics for detection of cancer in urine publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaa3519 – volume: 21 year: 2009 ident: 10.1016/j.mtbio.2023.100543_bib33 article-title: Cell-free supernatants of Escherichia coli Nissle 1917 modulate human colonic motility: evidence from an in vitro organ bath study publication-title: Neuro Gastroenterol. Motil. – volume: 261 year: 2020 ident: 10.1016/j.mtbio.2023.100543_bib17 article-title: Obligate and facultative anaerobic bacteria in targeted cancer therapy: current strategies and clinical applications publication-title: Life Sci. doi: 10.1016/j.lfs.2020.118296 – volume: 6 year: 1917 ident: 10.1016/j.mtbio.2023.100543_bib29 article-title: Affects Salmonella adhesion to porcine intestinal epithelial cells publication-title: PLoS One – volume: 170 start-page: 74 year: 2019 ident: 10.1016/j.mtbio.2023.100543_bib52 article-title: Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy publication-title: Res. Microbiol. doi: 10.1016/j.resmic.2018.11.001 – volume: 4 start-page: 6820 year: 2016 ident: 10.1016/j.mtbio.2023.100543_bib58 article-title: Genetically engineering of Escherichia coli and immobilization on electrospun fibers for drug delivery purposes publication-title: J. Mater. Chem. B. doi: 10.1039/C6TB01165A |
| SSID | ssj0002794009 |
| Score | 2.476878 |
| Snippet | With the in-depth and comprehensive study of bacteria and their related ecosystems in the human body, bacterial-based drug delivery system has become an... |
| SourceID | doaj pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 100543 |
| SubjectTerms | Drug delivery system E. coli Nissle 1917 Genetic engineering Living Materials edited by Chao Zhong Surface modification |
| Title | Advances in Escherichia coli Nissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies |
| URI | https://dx.doi.org/10.1016/j.mtbio.2023.100543 https://www.ncbi.nlm.nih.gov/pubmed/36647536 https://www.proquest.com/docview/2766431948 https://pubmed.ncbi.nlm.nih.gov/PMC9840185 https://doaj.org/article/a66f8da8ad484ff9a5dbd30f2caa35e5 |
| Volume | 18 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1NT9wwELUQp3JA_e7SFrlSj42a9VeSI61ACKmcisTNmsQ2DVoCItkDl_72ztjJatNK9MJxJ97d2PMSv4lfnhn7LOVSY91TZUYqyJQp86zOXZP5YFRAfLkA9Gjgx7k5vVBnl_pya6sv0oQle-A0cF_BmFA6KMGpUoVQgXa1k3kQDYDUPrqX4py3VUxdx-U02vCbuC_Se3p12qjJciiKu26GuqVX_4QkmYBWcjYtRff-2ez0L_v8W0S5NSudPGf7I53kR6kbL9iO716yvS2TwVfs91Fa5u952_HjnpLUksCZIwRafo4Dv_Kc6ikOPcfoGungDWm9MOzu11fc-RWJNx54cn3mSHP5uK7DNzp1Dp3DaNTttT3vh8mC4jW7ODn--f00G3ddyBot9JAFcKHxoQqqKvJaGi2KIDCSAzgsr2QtoCyhWuIn8obH-yPZ2zaFcXjPFbqWb9hud9v5d4yLAps0psDGVIiFUkDhm4CMA6uu3JULJqZBt81oSU47Y6zspD27tjFTljJlU6YW7MvmS3fJkePx5t8om5umZKcdAwgyO4LM_g9kC2YmLNiRmSTGgT_VPv7vnybkWLxuaTEGOn-77q0oDJLBZaVwFN4mJG3OUeIhLCPNghUzjM06MT_Stb-iN3iFBTtSsIOn6PV79oy6kjTqH9jucL_2H5GCDfVhvNoO47OxP_xVMlc |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Advances+in+Escherichia+coli+Nissle+1917+as+a+customizable+drug+delivery+system+for+disease+treatment+and+diagnosis+strategies&rft.jtitle=Materials+today+bio&rft.au=Chen%2C+Haojie&rft.au=Lei%2C+Pengyu&rft.au=Ji%2C+Hao&rft.au=Yang%2C+Qinsi&rft.date=2023-02-01&rft.issn=2590-0064&rft.eissn=2590-0064&rft.volume=18&rft.spage=100543&rft_id=info:doi/10.1016%2Fj.mtbio.2023.100543&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2590-0064&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2590-0064&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2590-0064&client=summon |