Development of a minimally invasive simultaneous estimation method for quantifying translocator protein binding with [18F]FEPPA positron emission tomography

• Published in: EJNMMI research Vol. 13; no. 1; pp. 1 - 12
• Main Authors: Dassanayake, Praveen, Anazodo, Udunna C., Liu, Linshan, Narciso, Lucas, Iacobelli, Maryssa, Hicks, Justin, Rusjan, Pablo, Finger, Elizabeth, St Lawrence, Keith
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 12.01.2023; Springer Nature B.V; SpringerOpen
• Subjects: Accuracy; Affinity; Alzheimer's disease; Binding; Blood; Brain research; Cardiac Imaging; Emission analysis; Estimates; Feasibility studies; Image-derived input function; Imaging; Kinetic modeling; Medicine; Medicine & Public Health; Metabolites; Nuclear Medicine; Oncology; Original Research; Orthopedics; PET/MR; Positron emission; Positron emission tomography; Proteins; Radiology; Simultaneous estimation method; Tomography; Translocator protein (TSPO) imaging; Simultaneous estimation method; PET/MR; Translocator protein (TSPO) imaging; Kinetic modeling; Image-derived input function; Positron emission tomography

Background The purpose of this study was to assess the feasibility of using a minimally invasive simultaneous estimation method (SIME) to quantify the binding of the 18-kDa translocator protein tracer [ 18 F]FEPPA. Arterial sampling was avoided by extracting an image-derived input function (IDIF) th...