MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection

• Published in: PloS one Vol. 6; no. 8; p. e23135
• Main Authors: de Almeida, Leonardo A., Carvalho, Natalia B., Oliveira, Fernanda S., Lacerda, Thais L. S., Vasconcelos, Anilton C., Nogueira, Lucas, Bafica, Andre, Silva, Aristóbolo M., Oliveira, Sergio C.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2011; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Bacillus anthracis; Bacteria; Bacterial diseases; Bacterial infections; Biochemistry; Biology; Brucella; Brucella abortus; Brucella abortus - genetics; Brucella abortus - isolation & purification; Brucellosis - metabolism; Brucellosis - microbiology; Cell Line; Cytokines; Deoxyribonucleic acid; DNA; DNA, Bacterial - genetics; DNA-directed RNA polymerase; Domestic animals; Endoplasmic reticulum; Fever; Gene expression; Gram-negative bacteria; Immune response; Immune system; Immunology; Infections; Interferon; Interferon regulatory factor 3; Interferon Regulatory Factor-3 - physiology; Interferon-beta - biosynthesis; Intracellular signalling; Kinases; Listeria; Listeria monocytogenes; Macrophages; Macrophages - metabolism; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; MyD88 protein; Myeloid Differentiation Factor 88 - metabolism; Parasitology; Pathogens; Phenotypes; Phosphorylation; Proteins; Ribonucleic acid; RNA; RNA polymerase; RNA Polymerase III - metabolism; Signal transduction; Spleen; Spleen - cytology; Spleen - metabolism; Splenocytes; Stat1 protein; STAT1 Transcription Factor - metabolism; TNF-Related Apoptosis-Inducing Ligand - metabolism; Tuberculosis; Tumor necrosis factor-TNF; Viruses; β-Interferon; γ-Interferon; Brazil

Type I interferons (IFNs) are cytokines that orchestrate diverse immune responses to viral and bacterial infections. Although typically considered to be most important molecules in response to viruses, type I IFNs are also induced by most, if not all, bacterial pathogens. In this study, we addressed...