MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection - de Almeida, Leonardo A.; Carvalho, Natalia B.; Oliveira, Fernanda S.; Lacerda, Thais L. S.; Vasconcelos, Anilton C.; Nogueira, Lucas; Bafica, Andre; Silva, Aristóbolo M.; Oliveira, Sergio C. (PloS one, 2011)
Keywords: Animals; Apoptosis; Bacillus anthracis; Bacteria; Bacterial diseases; Bacterial infections; Biochemistry; Biology; Brucella; Brucella abortus; Brucella abortus - genetics; Brucella abortus - isolation & purification; Brucellosis - metabolism; Brucellosis - microbiology; Cell Line; Cytokines; Deoxyribonucleic acid; DNA; DNA, Bacterial - genetics; DNA-directed RNA polymerase; Domestic animals; Endoplasmic reticulum; Fever; Gene expression; Gram-negative bacteria; Immune response; Immune system; Immunology; Infections; Interferon; Interferon regulatory factor 3; Interferon Regulatory Factor-3 - physiology; Interferon-beta - biosynthesis; Intracellular signalling; Kinases; Listeria; Listeria monocytogenes; Macrophages; Macrophages - metabolism; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; MyD88 protein; Myeloid Differentiation Factor 88 - metabolism; Parasitology; Pathogens; Phenotypes; Phosphorylation; Proteins; Ribonucleic acid; RNA; RNA polymerase; RNA Polymerase III - metabolism; Signal transduction; Spleen; Spleen - cytology; Spleen - metabolism; Splenocytes; Stat1 protein; STAT1 Transcription Factor - metabolism; TNF-Related Apoptosis-Inducing Ligand - metabolism; Tuberculosis; Tumor necrosis factor-TNF; Viruses; β-Interferon; γ-Interferon; Brazil