Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

• Published in: Cancer cell Vol. 33; no. 2; pp. 187 - 201.e10
• Main Authors: Li, Chia-Wei, Lim, Seung-Oe, Chung, Ezra M., Kim, Yong-Soo, Park, Andrew H., Yao, Jun, Cha, Jong-Ho, Xia, Weiya, Chan, Li-Chuan, Kim, Taewan, Chang, Shih-Shin, Lee, Heng-Huan, Chou, Chao-Kai, Liu, Yen-Liang, Yeh, Hsin-Chih, Perillo, Evan P., Dunn, Andrew K., Kuo, Chu-Wei, Khoo, Kay-Hooi, Hsu, Jennifer L., Wu, Yun, Hsu, Jung-Mao, Yamaguchi, Hirohito, Huang, Tzu-Hsuan, Sahin, Aysegul A., Hortobagyi, Gabriel N., Yoo, Stephen S., Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.02.2018
• Subjects: Animals; Antibodies, Monoclonal - pharmacology; antibody-drug conjugate; B3GNT3; Cell Line, Tumor; Female; glycosylation; Humans; immune checkpoint blockade; immunosuppression; immunotherapy; Lymphocytes, Tumor-Infiltrating - drug effects; Lymphocytes, Tumor-Infiltrating - immunology; Mice, Inbred BALB C; N-Acetylglucosaminyltransferases - drug effects; N-Acetylglucosaminyltransferases - metabolism; PD-1; PD-L1; Programmed Cell Death 1 Receptor - immunology; receptor internalization; TNBC; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - immunology; Triple Negative Breast Neoplasms - metabolism; antibody-drug conjugate; receptor internalization; immunotherapy; PD-L1; B3GNT3; glycosylation; immunosuppression; TNBC; PD-1; immune checkpoint blockade

Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed that EGF induces programmed death ligand 1 (P...