Artemis Regulates Cell Cycle Recovery from the S Phase Checkpoint by Promoting Degradation of Cyclin E

• Published in: The Journal of biological chemistry Vol. 284; no. 27; pp. 18236 - 18243
• Main Authors: Wang, Haiyong, Zhang, Xiaoshan, Geng, Liyi, Teng, Lisong, Legerski, Randy J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.07.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins - metabolism; Cell Line; Cyclin E - metabolism; Cyclin-Dependent Kinase 2 - metabolism; DNA-Binding Proteins; DNA: , Repair, Recombination, and Chromosome Dynamics; Endonucleases; F-Box Proteins - metabolism; F-Box-WD Repeat-Containing Protein 7; Flow Cytometry; Humans; Kidney - cytology; Mutagenesis, Site-Directed; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oncogene Proteins - metabolism; Phosphorylation - physiology; Protein-Serine-Threonine Kinases - metabolism; RNA, Small Interfering; S Phase - physiology; Serine - metabolism; Stress, Physiological - physiology; Ubiquitin - metabolism; Ubiquitin-Protein Ligases - metabolism

Artemis, a member of the SNM1 gene family, is a known phosphorylation target of ATM, ATR, and DNA-PKcs. We have previously identified two serine residues in Artemis (Ser516 and Ser645) that are subject to phosphorylation by ATM and are involved in mediating recovery from the G2/M checkpoint in respo...