Methyltransferase Setdb1 Promotes Osteoblast Proliferation by Epigenetically Silencing Macrod2 with the Assistance of Atf7ip

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 16; p. 2580
• Main Authors: Zhang, Lijun, Xu, Liqun, Zhang, Xiaoyan, Wang, Ke, Tan, Yingjun, Li, Gaozhi, Wang, Yixuan, Xue, Tong, Sun, Quan, Cao, Xinsheng, Zhang, Ge, Hu, Zebing, Zhang, Shu, Shi, Fei
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2022; MDPI
• Subjects: Adipocytes; Bone loss; cell proliferation; Epigenetic inheritance; Epigenetics; Ethylenediaminetetraacetic acid; Fractures; Gene expression; Histones; Lim, S.L; Localization; Mechanical loading; Mechanical unloading; Methyltransferase; Osteoblasts; Osteoporosis; Proteins; Setdb1; Signal transduction; Space flight; Transferases; β-Catenin; Massachusetts; Japan; China; United States > US

Bone loss caused by mechanical unloading is a threat to prolonged space flight and human health. Epigenetic modifications play a crucial role in varied biological processes, but the mechanism of histone modification on unloading-induced bone loss has rarely been studied. Here, we discovered for the...