NanI and NanJ Sialidases of Clostridium perfringens Are Not Essential for Virulence

• Published in: Infection and Immunity Vol. 77; no. 10; pp. 4421 - 4428
• Main Authors: Chiarezza, Martina, Lyras, Dena, Pidot, Sacha J, Flores-Díaz, Marietta, Awad, Milena M, Kennedy, Catherine L, Cordner, Leanne M, Phumoonna, Tongted, Poon, Rachael, Hughes, Meredith L, Emmins, John J, Alape-Girón, Alberto, Rood, Julian I
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.10.2009; American Society for Microbiology (ASM)
• Subjects: Animal models; Animals; Bacterial Proteins; Bacterial Proteins - genetics; Bacterial Proteins - physiology; Biological and medical sciences; Cell Line, Tumor; Cell Survival; Clostridium; Clostridium perfringens; Clostridium perfringens - enzymology; Clostridium perfringens - pathogenicity; Cytotoxicity; enzymology; Extracellular enzymes; Fundamental and applied biological sciences. Psychology; Gas Gangrene; Gas Gangrene - microbiology; Gene Knockout Techniques; genes; genetics; homologous recombination; Melanoma; Mice; Mice, Inbred BALB C; Microbiology; Molecular Pathogenesis; Mutagenesis, Insertional; mutants; Mutation; Myonecrosis; Neuraminidase; Neuraminidase - genetics; Neuraminidase - physiology; pathogenicity; Pathogens; physiology; sialidase; Survival Analysis; Toxins; Virulence; Virulence Factors; Virulence Factors - genetics; Virulence Factors - physiology; Glycosylases; Microbiology; Enzyme; Glycosidases; Exo-α-sialidase; Virulence; Clostridiaceae; Clostridiales; Bacteria; Hydrolases; Immunity; Clostridium perfringens

The essential toxin in Clostridium perfringens-mediated gas gangrene or clostridial myonecrosis is alpha-toxin, although other toxins and extracellular enzymes may also be involved. In many bacterial pathogens extracellular sialidases are important virulence factors, and it has been suggested that s...