Dynamic Interaction Between SARS-CoV-2 and Influenza A Virus Infection in Human Respiratory Tissues and Cells

• Published in: Microorganisms (Basel) Vol. 13; no. 5; p. 988
• Main Authors: Ho, John C. W., Ng, Kachun, Ching, Rachel H. H., Peiris, Malik, Nicholls, John M., Chan, Michael C. W., Hui, Kenrie P. Y.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2025; MDPI
• Subjects: ACE2; Alveoli; Angiotensin-converting enzyme 2; Antibodies; Avian flu; Avian influenza; Avian influenza viruses; co-infection; COVID-19; Cytokines; Disease; Enzymes; Epithelial cells; Epithelium; Explants; Gene expression; Health aspects; Immune response; Infection; Infections; Influenza; Influenza A; innate immune response; Innate immunity; Older people; Pandemics; Replication; respiratory explant; Respiratory tract; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Viral antibodies; Viral diseases; Viruses; United States; Illinois; China; Hong Kong China; United States > US; influenza; SARS-CoV-2; respiratory explant; co-infection; innate immune response

With the concurrent circulations of SARS-CoV-2 omicron and influenza A viruses in the community, there is evidence showing co-infection with both viruses. However, disease severity may vary due to the complex immunity landscape of the patients and the neutralizing antibody waning status. The intrins...