Specificity of Gap Junction Communication among Human Mammary Cells and Connexin Transfectants in Culture

• Published in: The Journal of cell biology Vol. 122; no. 1; pp. 157 - 167
• Main Authors: Tomasetto, Catherine, Neveu, Mark J., Daley, John, Horan, Paul K., Sager, Ruth
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.07.1993; The Rockefeller University Press
• Subjects: Biological and medical sciences; Blotting, Western; Breast - physiology; Breast Neoplasms; Cell coat. Cell surface; Cell Communication; Cell growth; Cell Line; Cell lines; Cell structures and functions; Cells; Cellular biology; Complementary DNA; Connexins; Dyes; Epidermal cells; Epithelial cells; Epithelium - physiology; Female; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Gap junctions; Humans; Intercellular Junctions - physiology; Membrane Proteins - biosynthesis; Membrane Proteins - genetics; Membrane Proteins - physiology; Molecular and cellular biology; Plasmids; Recombinant Proteins - biosynthesis; Transfection; Human; Specificity; Cell junction; Tumor; Mammary gland; Gene expression; Heterologous; Gap junction

In a previous paper, it was shown that normal human mammary epithelial cells (NMEC) express two connexin genes, Cx26 and Cx43, whereas neither gene is transcribed in a series of mammary tumor cell lines (TMEC). In this paper it is shown that normal human mammary fibroblasts (NMF) communicate and exp...