Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21
Triptolide is used in traditional Chinese medicine. It has the advantages of a unique mechanism of action, a wide antitumor spectrum, multiple targets, multi-channel effects and low toxicity. The current study was conducted to evaluate whether the potential anticancer effects of triptolide reduces p...
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Published in | Molecular medicine reports Vol. 13; no. 3; pp. 2763 - 2768 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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D.A. Spandidos
01.03.2016
Spandidos Publications Spandidos Publications UK Ltd |
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Abstract | Triptolide is used in traditional Chinese medicine. It has the advantages of a unique mechanism of action, a wide antitumor spectrum, multiple targets, multi-channel effects and low toxicity. The current study was conducted to evaluate whether the potential anticancer effects of triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer (NSCLC) cells, and to assess the underlying anticancer mechanisms. In PC-9 cells, treatment with triptolide reduced cell proliferation and increased cell apoptosis and caspase-3 and 9 activity. Triptolide treatment reduced miR-21 expression and enhanced phosphatase and tensin homolog (PTEN) protein expression levels in the PC-9 cells. Furthermore, the upregulation of miR-21 expression levels suppressed the effect of triptolide on cell viability and PTEN protein expression levels in PC-9 cells. To the best of our knowledge, the present study is the first to demonstrate that triptolide reduced the proliferation and enhanced the apoptosis of human NSCLC cells through PTEN by targeting miR-21. |
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AbstractList | Triptolide is used in traditional Chinese medicine. It has the advantages of a unique mechanism of action, a wide antitumor spectrum, multiple targets, multi-channel effects and low toxicity. The current study was conducted to evaluate whether the potential anticancer effects of triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer (NSCLC) cells, and to assess the underlying anticancer mechanisms. In PC-9 cells, treatment with triptolide reduced cell proliferation and increased cell apoptosis and caspase-3 and 9 activity. Triptolide treatment reduced miR-21 expression and enhanced phosphatase and tensin homolog (PTEN) protein expression levels in the PC-9 cells. Furthermore, the upregulation of miR-21 expression levels suppressed the effect of triptolide on cell viability and PTEN protein expression levels in PC-9 cells. To the best of our knowledge, the present study is the first to demonstrate that triptolide reduced the proliferation and enhanced the apoptosis of human NSCLC cells through PTEN by targeting miR-21. Triptolide is used in traditional Chinese medicine. It has the advantages of a unique mechanism of action, a wide antitumor spectrum, multiple targets, multi-channel effects and low toxicity. The current study was conducted to evaluate whether the potential anticancer effects of triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer (NSCLC) cells, and to assess the underlying anticancer mechanisms. In PC-9 cells, treatment with triptolide reduced cell proliferation and increased cell apoptosis and caspase-3 and 9 activity. Triptolide treatment reduced miR-21 expression and enhanced phosphatase and tensin homolog (PTEN) protein expression levels in the PC-9 cells. Furthermore, the upregulation of miR-21 expression levels suppressed the effect of triptolide on cell viability and PTEN protein expression levels in PC-9 cells. To the best of our knowledge, the present study is the first to demonstrate that triptolide reduced the proliferation and enhanced the apoptosis of human NSCLC cells through PTEN by targeting miR-21. Key words: triptolide, non-small cell lung cancer, phosphatase and tensin homolog, miR-21 |
Audience | Academic |
Author | LI, XIAOFANG ZHU, XIAOWEI JIAO, JIN FENG, JIA ZHANG, LEI JIA, YOUCHAO DUAN, MINDAN HUO, RAN ZANG, AIMIN ZHANG, JINCHAO FAN, WUFANG |
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Snippet | Triptolide is used in traditional Chinese medicine. It has the advantages of a unique mechanism of action, a wide antitumor spectrum, multiple targets,... |
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SubjectTerms | Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Caspase Caspase-3 Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Development and progression Diterpenes - pharmacology Drug Screening Assays, Antitumor Epoxy compounds Epoxy Compounds - pharmacology Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Lung cancer Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Medical prognosis Medical research MicroRNA MicroRNAs - physiology miR-21 non-small cell lung cancer Non-small cell lung carcinoma Phenanthrenes - pharmacology phosphatase and tensin homolog Properties Protein expression Proteins PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein RNA Interference Signal transduction Studies Tensin Toxicity Traditional Chinese medicine Triptolide Tumors |
Title | Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21 |
URI | https://www.ncbi.nlm.nih.gov/pubmed/26847601 https://www.proquest.com/docview/1932867958/abstract/ https://search.proquest.com/docview/1779892770 |
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