Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state

• Published in: British Journal of Anaesthesia Vol. 78; no. 4; pp. 400 - 406
• Main Authors: Taittonen, M T, Kirvelä, O A, Aantaa, R, Kanto, J H
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 01.04.1997; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: Adrenergic alpha-Agonists - pharmacology; Adult; Anesthesia, General; Biological and medical sciences; Cardiovascular system; Clonidine - pharmacology; Double-Blind Method; Female; Hemodynamics - drug effects; Humans; Imidazoles - pharmacology; Male; Medetomidine; Medical sciences; Middle Aged; Miscellaneous; Oxygen Consumption - drug effects; Pharmacology. Drug treatments; Premedication; Surgery, Plastic; Sympatholytics - pharmacology; Human; α2-Adrenergic receptor; Agonist; Dexmedetomidine; General anesthesia; Oxygen consumption; Clonidine; Hemodynamics; Catecholamine; Sympathetic nervous system; Premedication

Premedication has been shown to affect both oxygen consumption and metabolic rate. We have compared the perioperative metabolic and haemodynamic effects of two alpha 2-agonists, clonidine and the more selective dexmedetomidine, in 30 ASA I patients undergoing plastic surgical procedures under genera...