Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

• Published in: Cancer cell Vol. 37; no. 1; pp. 104 - 122.e12
• Main Authors: Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.01.2020
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Apoptosis; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; dormancy; drug resistance; Drug Resistance, Neoplasm; drug tolerance; epidermal growth factor receptor; ErbB Receptors - metabolism; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; lung cancer; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Male; MAP Kinase Kinase 1 - metabolism; Mice; Mice, Knockout; Mutation; senescence; Signal Transduction; Transcription Factors - metabolism; Transcription, Genetic; YAP; YAP-Signaling Proteins; lung cancer; senescence; epidermal growth factor receptor; dormancy; YAP; drug resistance; drug tolerance

Eradicating tumor dormancy that develops following epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small cell lung cancer, is an attractive therapeutic strategy but the mechanisms governing this process are poorly understood. Blockade of ERK1/2 re...