Nuclear factor-κB-dependent epithelial to mesenchymal transition induced by HIF-1α activation in pancreatic cancer cells under hypoxic conditions

• Published in: PloS one Vol. 6; no. 8; p. e23752
• Main Authors: Cheng, Zhuo-Xin, Sun, Bei, Wang, Shuang-Jia, Gao, Yue, Zhang, Ying-Mei, Zhou, Hao-Xin, Jia, Guang, Wang, Yong-Wei, Kong, Rui, Pan, Shang-Ha, Xue, Dong-Bo, Jiang, Hong-Chi, Bai, Xue-Wei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2011; Public Library of Science (PLoS)
• Subjects: Biology; Cadherins; Cancer; Cancer therapies; Cell Line, Tumor; Chemotherapy; Collagen; Drug resistance; E-cadherin; Epithelial-Mesenchymal Transition; Gene Expression; Genotype & phenotype; Humans; Hypoxia; Hypoxia - complications; Hypoxia - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - administration & dosage; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factors; Invasiveness; Kinases; Localization; Medicine; Mesenchyme; Metastasis; Molecular modelling; N-Cadherin; NF-kappa B - physiology; NF-κB protein; Pancreatic cancer; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pharmacology; Phenotype; Phenotypes; Prostate cancer; Proteins; Rodents; Surgery; Tumor Cells, Cultured; China

Epithelial to mesenchymal transition (EMT) induced by hypoxia is one of the critical causes of treatment failure in different types of human cancers. NF-κB is closely involved in the progression of EMT. Compared with HIF-1α, the correlation between NF-κB and EMT during hypoxia has been less studied,...