PRMT1 is an important factor for medulloblastoma cell proliferation and survival

• Published in: Biochemistry and biophysics reports Vol. 32; p. 101364
• Main Authors: Gu, Xiao, He, Miao, Lebedev, Timofey, Lin, Cheng-Han, Hua, Zhong-Yan, Zheng, Y. George, Li, Zhi-Jie, Yang, Jer-Yen, Li, Xing-Guo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2022; Elsevier
• Subjects: Diamidine compounds; Medulloblastoma; PRMT1; PRMT1 inhibitors; PRMT1 inhibitors; Diamidine compounds; Dox; PRMT1; shRNA; Medulloblastoma; Dox, Doxycycline; shRNA, short hairpin RNA; PRMT1, protein arginine methyltransferase 1

Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of brain tumors, but the role of PRMT1 in medulloblastoma, the most common malignant pediatric brain tumor, remains unexplored. By examining the publicly available databases of pediatric brain tumor co...