The clinical impact of miRNA34a and P53 gene expression in colon cancer

To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of colorectal cancer. This study was carried out 30 patients with colon adenocarcinoma, 30 patients with benign colon polyp and 30 apparently healthy pe...

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Published inBiochemistry and biophysics reports Vol. 16; pp. 88 - 95
Main Authors Badr, Eman A.E., Ali Assar, Mohamed Farag, Gohar, Suzy F., Badr, Mohamed Hamdy, Hathout, Rawda Magdy, El-kousy, Salah Mohamed
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2018
Elsevier
Subjects
Cancer – colon/rectal
Cell – biology
Clinical research
Cancer – colon/rectal
Clinical research
Cell – biology
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Abstract To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of colorectal cancer. This study was carried out 30 patients with colon adenocarcinoma, 30 patients with benign colon polyp and 30 apparently healthy persons served as controls. All participants were subjected to full history taking, general clinical examination. Complete blood count, liver and kidney function, determination of serum tumor markers were done. Estimation of microRNA 34a and P53 Gene expression by real-time PCR were done. There was a significant negative relationship between serum tumor markers and micro RNA 34a gene expression in cancer patients. Also, there was a statistically significant positive relationship between miRNA34a gene expression and P53 gene expression in both patients groups. The diagnostic accuracy of miRNA34a gene expression was both sensitive and specific for colon cancer. MiRNA34a and P53 gene expression had statistically significant relation with tumor stage and presence of metastases. It can be concluded that the level of miRNA34a can be used to differentiate between colon cancers and begin adenomas. MiRNA34a can be used as a prognostic marker in colon cancer. •MiRNA34a has an important role in colon cancer.•Presence of correlation between P53 and miRNA34a gene expression.•MiRNA34a can be used as a prognostic marker in colon cancer.•MiRNA34a can be used to differentiate between colon cancer and benign adenoma.
AbstractList • MiRNA34a has an important role in colon cancer. • Presence of correlation between P53 and miRNA34a gene expression. • MiRNA34a can be used as a prognostic marker in colon cancer. • MiRNA34a can be used to differentiate between colon cancer and benign adenoma.
To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of colorectal cancer. This study was carried out 30 patients with colon adenocarcinoma, 30 patients with benign colon polyp and 30 apparently healthy persons served as controls. All participants were subjected to full history taking, general clinical examination. Complete blood count, liver and kidney function, determination of serum tumor markers were done. Estimation of microRNA 34a and P53 Gene expression by real-time PCR were done. There was a significant negative relationship between serum tumor markers and micro RNA 34a gene expression in cancer patients. Also, there was a statistically significant positive relationship between miRNA34a gene expression and P53 gene expression in both patients groups. The diagnostic accuracy of miRNA34a gene expression was both sensitive and specific for colon cancer. MiRNA34a and P53 gene expression had statistically significant relation with tumor stage and presence of metastases. It can be concluded that the level of miRNA34a can be used to differentiate between colon cancers and begin adenomas. MiRNA34a can be used as a prognostic marker in colon cancer. •MiRNA34a has an important role in colon cancer.•Presence of correlation between P53 and miRNA34a gene expression.•MiRNA34a can be used as a prognostic marker in colon cancer.•MiRNA34a can be used to differentiate between colon cancer and benign adenoma.
OBJECTIVETo study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of colorectal cancer. PATIENTS AND METHODSThis study was carried out 30 patients with colon adenocarcinoma, 30 patients with benign colon polyp and 30 apparently healthy persons served as controls. All participants were subjected to full history taking, general clinical examination. Complete blood count, liver and kidney function, determination of serum tumor markers were done. Estimation of microRNA 34a and P53 Gene expression by real-time PCR were done. RESULTSThere was a significant negative relationship between serum tumor markers and micro RNA 34a gene expression in cancer patients. Also, there was a statistically significant positive relationship between miRNA34a gene expression and P53 gene expression in both patients groups. The diagnostic accuracy of miRNA34a gene expression was both sensitive and specific for colon cancer. MiRNA34a and P53 gene expression had statistically significant relation with tumor stage and presence of metastases. CONCLUSIONIt can be concluded that the level of miRNA34a can be used to differentiate between colon cancers and begin adenomas. MiRNA34a can be used as a prognostic marker in colon cancer.
Objective: To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of colorectal cancer. Patients and methods: This study was carried out 30 patients with colon adenocarcinoma, 30 patients with benign colon polyp and 30 apparently healthy persons served as controls. All participants were subjected to full history taking, general clinical examination. Complete blood count, liver and kidney function, determination of serum tumor markers were done. Estimation of microRNA 34a and P53 Gene expression by real-time PCR were done. Results: There was a significant negative relationship between serum tumor markers and micro RNA 34a gene expression in cancer patients. Also, there was a statistically significant positive relationship between miRNA34a gene expression and P53 gene expression in both patients groups. The diagnostic accuracy of miRNA34a gene expression was both sensitive and specific for colon cancer. MiRNA34a and P53 gene expression had statistically significant relation with tumor stage and presence of metastases. Conclusion: It can be concluded that the level of miRNA34a can be used to differentiate between colon cancers and begin adenomas. MiRNA34a can be used as a prognostic marker in colon cancer. Keywords: Cancer – colon/rectal, Cell – biology, Clinical research
To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of colorectal cancer. This study was carried out 30 patients with colon adenocarcinoma, 30 patients with benign colon polyp and 30 apparently healthy persons served as controls. All participants were subjected to full history taking, general clinical examination. Complete blood count, liver and kidney function, determination of serum tumor markers were done. Estimation of microRNA 34a and P53 Gene expression by real-time PCR were done. There was a significant negative relationship between serum tumor markers and micro RNA 34a gene expression in cancer patients. Also, there was a statistically significant positive relationship between miRNA34a gene expression and P53 gene expression in both patients groups. The diagnostic accuracy of miRNA34a gene expression was both sensitive and specific for colon cancer. MiRNA34a and P53 gene expression had statistically significant relation with tumor stage and presence of metastases. It can be concluded that the level of miRNA34a can be used to differentiate between colon cancers and begin adenomas. MiRNA34a can be used as a prognostic marker in colon cancer.
Author El-kousy, Salah Mohamed
Ali Assar, Mohamed Farag
Hathout, Rawda Magdy
Badr, Eman A.E.
Badr, Mohamed Hamdy
Gohar, Suzy F.
AuthorAffiliation c Department of Clinical Oncology, Faculty of Medicine - Menoufia University, Egypt
a Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine - Menoufia University, Egypt
b Department of Chemistry, Biochemistry Division, Faculty of science - Menoufia University, Egypt
d Department of Internal Medicine, Faculty of Medicine - Menoufia University, Egypt
f Department of Organic chemistry, Faculty of science - Menoufia University, Egypt
e Chemist at Faculty of Science – Menoufia University, Egypt
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Keywords Cancer – colon/rectal
Clinical research
Cell – biology
Language English
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Snippet To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of...
OBJECTIVETo study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival of...
• MiRNA34a has an important role in colon cancer. • Presence of correlation between P53 and miRNA34a gene expression. • MiRNA34a can be used as a prognostic...
Objective: To study the potential role of miRNA34a gene expression and its relationship with P53 gene expression, fate, stage, metastasis and overall survival...
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StartPage 88
SubjectTerms Cancer – colon/rectal
Cell – biology
Clinical research
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Title The clinical impact of miRNA34a and P53 gene expression in colon cancer
URI https://dx.doi.org/10.1016/j.bbrep.2018.10.002
https://www.ncbi.nlm.nih.gov/pubmed/30377673
https://search.proquest.com/docview/2127660517
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