MU-LOC: A Machine-Learning Method for Predicting Mitochondrially Localized Proteins in Plants

• Published in: Frontiers in plant science Vol. 9; p. 634
• Main Authors: Zhang, Ning, Rao, R. S. P., Salvato, Fernanda, Havelund, Jesper F., Møller, Ian M., Thelen, Jay J., Xu, Dong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.05.2018
• Subjects: deep neural network; gene co-expression; machine learning; mitochondrial targeting; Plant Science; position weight matrix; support vector machine; position weight matrix; gene co-expression; support vector machine; machine learning; deep neural network; mitochondrial targeting

Targeting and translocation of proteins to the appropriate subcellular compartments are crucial for cell organization and function. Newly synthesized proteins are transported to mitochondria with the assistance of complex targeting sequences containing either an N-terminal pre-sequence or a multitud...