Static and Dynamic Changes in Local Brain Connectivity in Unilateral Sudden Sensorineural Hearing Loss

Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102...

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Published inBioengineering (Basel) Vol. 12; no. 6; p. 619
Main Authors Zeng, Junchao, Li, Jing, Liu, Bo, Yu, Qun, Lei, Ziqiao, Yang, Fan, Ding, Mingyue, Fan, Wenliang
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 05.06.2025
MDPI
Subjects
Audiometry
Auditory plasticity
Brain
Brain research
Comparative analysis
Correlation analysis
Development and progression
dynamic local metric
Education
Frontal gyrus
Hearing
Hearing loss
Homogeneity
Investigations
Liu Bo
local brain connectivity
Magnetic resonance imaging
Mental disorders
Neural networks
neuroimaging biomarkers
Neuroplasticity
Precentral gyrus
Quality of life
Synchronism
Synchronization
Tinnitus
unilateral sudden sensorineural hearing loss
China
Taiwan
neuroimaging biomarkers
local brain connectivity
dynamic local metric
unilateral sudden sensorineural hearing loss
Online AccessGet full text
ISSN2306-5354
2306-5354
DOI10.3390/bioengineering12060619

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Abstract Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, p < 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = −0.35, p < 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.
AbstractList Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, p < 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = -0.35, p < 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, p < 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = -0.35, p < 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.
Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, < 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = -0.35, < 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.
Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, p < 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = −0.35, p < 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.
Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, p < 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = −0.35, p < 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.
Audience Academic
Author Liu, Bo
Lei, Ziqiao
Yang, Fan
Yu, Qun
Li, Jing
Ding, Mingyue
Fan, Wenliang
Zeng, Junchao
AuthorAffiliation 5 Department of Otorhinolaryngology Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; liuboent@hust.edu.cn
2 Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; lijing80603@163.com (J.L.); boqun_002@163.com (Q.Y.); ziqiao_lei@hust.edu.cn (Z.L.); fyang@hust.edu.cn (F.Y.)
4 Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China
3 Hubei Provincial Clinical Research Center for Precision Radiology & Interventional Medicine, Wuhan 430022, China
1 Medical Ultrasound Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Advanced Bio-Medical Imaging Facility, Huazhong University of Science and Technology, Wuhan 430074, China; d202380995@hust.edu.cn
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Keywords neuroimaging biomarkers
local brain connectivity
dynamic local metric
unilateral sudden sensorineural hearing loss
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RelatedPersons Liu Bo
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Snippet Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood...
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SubjectTerms Audiometry
Auditory plasticity
Brain
Brain research
Comparative analysis
Correlation analysis
Development and progression
dynamic local metric
Education
Frontal gyrus
Hearing
Hearing loss
Homogeneity
Investigations
Liu Bo
local brain connectivity
Magnetic resonance imaging
Mental disorders
Neural networks
neuroimaging biomarkers
Neuroplasticity
Precentral gyrus
Quality of life
Synchronism
Synchronization
Tinnitus
unilateral sudden sensorineural hearing loss
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Title Static and Dynamic Changes in Local Brain Connectivity in Unilateral Sudden Sensorineural Hearing Loss
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Volume 12
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