TRAF4 acts as a fate checkpoint to regulate the adipogenic differentiation of MSCs by activating PKM2

• Published in: EBioMedicine Vol. 54; p. 102722
• Main Authors: Cen, Shuizhong, Li, Jinteng, Cai, Zhaopeng, Pan, Yiqian, Sun, Zehang, Li, Zhaofeng, Ye, Guiwen, Zheng, Guan, Li, Ming, Liu, Wenjie, Yu, Wenhui, Wang, Shan, Xie, Zhongyu, Wang, Peng, Shen, Huiyong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2020; Elsevier
• Subjects: Adipocytes - cytology; Adipocytes - metabolism; Adipogenesis; Adipogenic differentiation; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cells, Cultured; HEK293 Cells; Humans; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; PKM2; Protein Binding; Research paper; Thyroid Hormone-Binding Proteins; Thyroid Hormones - genetics; Thyroid Hormones - metabolism; TNF Receptor-Associated Factor 4 - genetics; TNF Receptor-Associated Factor 4 - metabolism; TRAF4; Adipogenic differentiation; TRAF4; PKM2; Mesenchymal stem cells

Mesenchymal stem cells (MSCs) selectively differentiate into adipocytes or osteoblasts, and several molecules control the fate determination of MSCs. Understanding these key checkpoints greatly contributes to the ability to induce specific MSC differentiation for clinical applications. In this study...