Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation - Ni, Wen; Mo, Hui; Liu, Yuanyuan; Xu, Yuanyuan; Qin, Chao; Zhou, Yunxia; Li, Yuhui; Li, Yuqing; Zhou, Aijun; Yao, Su; Zhou, Rong; Huo, Jianping; et al. (Molecular therapy, 2021)
Keywords: Adult; Aged; Aged, 80 and over; Animals; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Cell Line, Tumor; Cholesterol - biosynthesis; colorectal cancer; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Female; Gene Expression Regulation, Neoplastic - drug effects; HCT116 Cells; HT29 Cells; Humans; Hydroxymethylglutaryl CoA Reductases - metabolism; immune-checkpoint PD-L1; immunotherapy; lncRNA SNHG29; Male; Mice; Middle Aged; Original; Phosphorylation - drug effects; RNA, Long Noncoding - genetics; Signal Transduction - drug effects; simvastatin; Simvastatin - administration & dosage; Simvastatin - pharmacology; Tumor Microenvironment - drug effects; Ubiquitination - drug effects; Xenograft Model Antitumor Assays; YAP activation; YAP-Signaling Proteins - genetics; YAP-Signaling Proteins - metabolism; simvastatin; lncRNA SNHG29; YAP activation; colorectal cancer; immune-checkpoint PD-L1; immunotherapy