High Glucose Induces Mesangial Cell Apoptosis through miR-15b-5p and Promotes Diabetic Nephropathy by Extracellular Vesicle Delivery

• Published in: Molecular therapy Vol. 28; no. 3; pp. 963 - 974
• Main Authors: Tsai, Yi-Chun, Kuo, Mei-Chuan, Hung, Wei-Wen, Wu, Ling-Yu, Wu, Ping-Hsun, Chang, Wei-An, Kuo, Po-Lin, Hsu, Ya-Ling
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.03.2020; American Society of Gene & Cell Therapy
• Subjects: Animals; Apoptosis - genetics; BCL-2; Biological Transport; Biomarkers; Blood Glucose; Cell Line; Diabetic Nephropathies - etiology; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; diabetic nephropathy; Disease Susceptibility; extracellular vesicle; Extracellular Vesicles - metabolism; Gene Expression Profiling; Gene Expression Regulation; Genes, bcl-2; Glucose - metabolism; Humans; Immunohistochemistry; Immunophenotyping; mesangial cell apoptosis; Mesangial Cells - metabolism; Mesangial Cells - pathology; Mice; MicroRNAs - genetics; miR-15; Models, Biological; Original; RNA Interference; BCL-2; extracellular vesicle; miR-15; mesangial cell apoptosis; diabetic nephropathy

Diabetic nephropathy (DN) is an increasing threat to human health and is regarded as an important public issue. The pathophysiologic mechanisms of DN are complicated. The initiating molecular events triggering the loss function in mesangial cells (MCs) in DN are not well known. In this cross-discipl...