Autoantibodies against type I IFNs in patients with life-threatening COVID-19

• Published in: Science (American Association for the Advancement of Science) Vol. 370; no. 6515; p. 423
• Main Authors: Bastard, Paul, Rosen, Lindsey B., Zhang, Qian, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Zhang, Yu, Dorgham, Karim, Philippot, Quentin, Rosain, Jérémie, Béziat, Vivien, Manry, Jérémy, Shaw, Elana, Haljasmägi, Liis, Peterson, Pärt, Lorenzo, Lazaro, Bizien, Lucy, Trouillet-Assant, Sophie, Dobbs, Kerry, de Jesus, Adriana Almeida, Belot, Alexandre, Kallaste, Anne, Catherinot, Emilie, Tandjaoui-Lambiotte, Yacine, Le Pen, Jeremie, Kerner, Gaspard, Bigio, Benedetta, Seeleuthner, Yoann, Yang, Rui, Bolze, Alexandre, Spaan, András N., Delmonte, Ottavia M., Abers, Michael S., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Piemonti, Lorenzo, Ciceri, Fabio, Bilguvar, Kaya, Lifton, Richard P., Vasse, Marc, Smadja, David M., Migaud, Mélanie, Hadjadj, Jérome, Terrier, Benjamin, Duffy, Darragh, Quintana-Murci, Lluis, van de Beek, Diederik, Roussel, Lucie, Vinh, Donald C., Tangye, Stuart G., Haerynck, Filomeen, Dalmau, David, Martinez-Picado, Javier, Brodin, Petter, Nussenzweig, Michel C., Boisson-Dupuis, Stéphanie, Rodríguez-Gallego, Carlos, Vogt, Guillaume, Mogensen, Trine H., Oler, Andrew J., Gu, Jingwen, Burbelo, Peter D., Cohen, Jeffrey I., Biondi, Andrea, Bettini, Laura Rachele, D'Angio, Mariella, Bonfanti, Paolo, Rossignol, Patrick, Mayaux, Julien, Rieux-Laucat, Frédéric, Husebye, Eystein S., Fusco, Francesca, Ursini, Matilde Valeria, Imberti, Luisa, Sottini, Alessandra, Paghera, Simone, Quiros-Roldan, Eugenia, Rossi, Camillo, Castagnoli, Riccardo, Montagna, Daniela, Licari, Amelia, Marseglia, Gian Luigi, Duval, Xavier, Ghosn, Jade, Tsang, John S., Goldbach-Mansky, Raphaela, Kisand, Kai, Lionakis, Michail S., Puel, Anne, Zhang, Shen-Ying, Holland, Steven M., Gorochov, Guy, Jouanguy, Emmanuelle, Rice, Charles M., Cobat, Aurélie, Notarangelo, Luigi D., Abel, Laurent, Su, Helen C., Casanova, Jean-Laurent, Arias, Andrés Augusto
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 23.10.2020; American Association for the Advancement of Science (AAAS); American Association for the Advancement of Science
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing; Antibodies, Neutralizing - blood; Antiviral drugs; Asymptomatic; Asymptomatic Infections; Autoantibodies; Autoantibodies - blood; Autoimmunity; Betacoronavirus; Case-Control Studies; Control Groups; Coronaviridae; Coronavirus Infections; Coronavirus Infections - immunology; Coronaviruses; COVID-19; Critical Illness; Cytokines; Disease; Female; Genetics; Humans; Immune system; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulins; Immunology; Infections; Infectious diseases; Interferon alpha-2; Interferon alpha-2 - immunology; Interferon Type I; Interferon Type I - immunology; Life Sciences; Male; Males; Middle Aged; Mutation; Online; Pandemics; Patients; Pneumonia; Pneumonia, Viral; Pneumonia, Viral - immunology; Public health; Respiratory diseases; Risk factors; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Viral infections

The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induc...