MIC-1, a Novel Macrophage Inhibitory Cytokine, is a Divergent Member of the TGF-β superfamily

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 94; no. 21; pp. 11514 - 11519
• Main Authors: Bootcov, Michelle R., Bauskin, Asne R., Valenzuela, Stella M., Moore, Anthony G., Bansal, Mohinder, He, Xiao Yan, Zhang, Hong Ping, Donnellan, Melissa, Mahler, Stephen, Pryor, Kimberley, Walsh, Bradley J., Nicholson, Richard C., Fairlie, W. Douglas, Por, Suzanne B., Robbins, Joan M., Breit, Samuel N.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 14.10.1997; National Acad Sciences; National Academy of Sciences; The National Academy of Sciences of the USA
• Subjects: Amino Acid Sequence; Amino acids; Animals; Bacteriophages; Base Sequence; Biological Sciences; Cell Line; Cell lines; Cells, Cultured; Cellular biology; Chickens; Cytokines; Cytokines - biosynthesis; Cytokines - chemistry; Cytokines - pharmacology; Gene Library; Genes; Growth Differentiation Factor 15; Humans; Immunity (Disease); Kidney cells; Lipopolysaccharides - pharmacology; Macrophage activation; Macrophage Activation - drug effects; Macrophages; Messenger RNA; Molecular Sequence Data; Molecules; Monocytes - drug effects; Monocytes - immunology; Phylogeny; Proteins; Recombinant Proteins - biosynthesis; Recombinant Proteins - chemistry; Recombinant Proteins - pharmacology; Secretion; Sequence Alignment; Sequence Homology, Amino Acid; Transfection; Transforming Growth Factor beta - biosynthesis; Transforming Growth Factor beta - chemistry; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha - biosynthesis; Xenopus

Macrophages play a key role in both normal and pathological processes involving immune and inflammatory responses, to a large extent through their capacity to secrete a wide range of biologically active molecules. To identify some of these as yet not characterized molecules, we have used a subtracti...