VPO1 Modulates Vascular Smooth Muscle Cell Phenotypic Switch by Activating Extracellular Signal‐regulated Kinase 1/2 (ERK 1/2) in Abdominal Aortic Aneurysms

• Published in: Journal of the American Heart Association Vol. 7; no. 17; p. e010069
• Main Authors: Peng, Huihui, Zhang, Kai, Liu, Zhaoya, Xu, Qian, You, Baiyang, Li, Chan, Cao, Jing, Zhou, Honghua, Li, Xiaohui, Chen, Jia, Cheng, Guangjie, Shi, Ruizheng, Zhang, Guogang
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 04.09.2018; Wiley
• Subjects: abdominal aortic aneurysm; Aged; Animals; Aorta, Abdominal - cytology; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - physiopathology; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Hemeproteins - drug effects; Hemeproteins - metabolism; Humans; hydrogen peroxide; Hydrogen Peroxide - pharmacology; Hypochlorous Acid - pharmacology; Kruppel-Like Transcription Factors - metabolism; Male; MAP Kinase Signaling System; Matrix Metalloproteinase 2 - metabolism; Mice; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - physiopathology; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - metabolism; Original Research; Oxidants - pharmacology; oxidative stress; Peroxidases - drug effects; Peroxidases - metabolism; Phenotype; Reactive Oxygen Species; abdominal aortic aneurysm; oxidative stress; hydrogen peroxide

Background Hydrogen peroxide (H O ) is a critical molecular signal in the development of abdominal aortic aneurysm ( AAA ) formation. Vascular peroxidase 1 ( VPO 1) catalyzes the production of hypochlorous acid ( HOC l) from H O and significantly enhances oxidative stress. The switch from a contract...