Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis

• Published in: Redox biology Vol. 41; p. 101915
• Main Authors: Guo, Yuanyuan, Jia, Xiong, Cui, Yongzhi, Song, Yu, Wang, Siyuan, Geng, Yongtao, Li, Rui, Gao, Weihang, Fu, Dehao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2021; Elsevier
• Subjects: Advanced glycation end products; Aging; Cell senescence; Cellular Senescence; Humans; Mesenchymal Stem Cells; Mitophagy; Osteoporosis; Research Paper; Senile osteoporosis; Sirtuin 3; Sirtuin3; Sirtuin3; TRAP5b; ALP; AGEs; Mitophagy; ORO; PPARγ; rAAV; CsA; MMP; SA-β-gal; Col1; Advanced glycation end products; Cell senescence; CCCP; OC; SOP; ROS; Sirts; CCK-8; AZR; Senile osteoporosis; GAPDH; BMSCs

Senile osteoporosis (SOP) is widely regarded as one of the typical aging-related diseases due to a decrease in bone mass and the destruction in microarchitecture. The inhibition of mitophagy can promote bone marrow mesenchymal stem cells (BMSCs) senescence, and increasing studies have shown that int...