Non-AUG start codons: Expanding and regulating the small and alternative ORFeome

• Published in: Experimental cell research Vol. 391; no. 1; p. 111973
• Main Authors: Cao, Xiongwen, Slavoff, Sarah A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020
• Subjects: Codon, Initiator - chemistry; Codon, Initiator - metabolism; Computational Biology - methods; Eukaryota - genetics; Eukaryota - metabolism; Genome; Genomics; High-Throughput Nucleotide Sequencing; Molecular Sequence Annotation - methods; Non-AUG start Codon; Open Reading Frames; Peptide Chain Initiation, Translational; Prokaryotic Cells - metabolism; Protein Sorting Signals - genetics; Proteome - classification; Proteome - genetics; Proteome - metabolism; Proteomics; Ribosomes - classification; Ribosomes - genetics; Ribosomes - metabolism; Small ORF; sORF; Small ORF; sORF; Genomics; Proteomics; Non-AUG start Codon

Recent ribosome profiling and proteomic studies have revealed the presence of thousands of novel coding sequences, referred to as small open reading frames (sORFs), in prokaryotic and eukaryotic genomes. These genes have defied discovery via traditional genomic tools not only because they tend to be...