Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3

• Published in: Haematologica (Roma) Vol. 92; no. 4; pp. 440 - 449
• Main Authors: De Becker, Ann, Van Hummelen, Paul, Bakkus, Marleen, Vande Broek, Isabelle, De Wever, Joke, De Waele, Marc, Van Riet, Ivan
• Format: Journal Article
• Language: English
• Published: Pavia Haematologica 01.04.2007; Ferrata Storti Foundation
• Subjects: Adipocytes - cytology; Biological and medical sciences; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; Bone Marrow Cells - metabolism; Cell Count; Cell Differentiation - drug effects; Cell Movement - drug effects; Cell Movement - physiology; Cells, Cultured - physiology; Chondrocytes - cytology; Collagen; Drug Combinations; Endothelium; Gene Expression Profiling; Hematologic and hematopoietic diseases; Humans; Laminin; Matrix Metalloproteinase 2 - physiology; Matrix Metalloproteinase 9 - physiology; Medical sciences; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Oligonucleotide Array Sequence Analysis; Organ Specificity; Osteocytes - cytology; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering - pharmacology; Tissue Inhibitor of Metalloproteinase-3 - biosynthesis; Tissue Inhibitor of Metalloproteinase-3 - genetics; Tissue Inhibitor of Metalloproteinase-3 - pharmacology; Tissue Inhibitor of Metalloproteinase-3 - physiology; Transfection; Up-Regulation; Human; Cell culture; Tissue inhibitor metalloproteinase 3; TIMP-3; mesenchymal stem cell; Hematology; Enzyme; Stem cell; Migration; Tissue inhibitor metalloproteinase 2; Metalloendopeptidases; culture confluence; Mesenchymal cell; Endothelium; Gelatinase A; Peptidases; MMP-2; Confluence; Bone marrow; Hydrolases

From the Stem Cell Laboratory (ADB, IVB, JDW, IVR) and Laboratory of Hematology-Immunology, Academic Hospital Vrije Universiteit Brussel (VUB), Brussels, Belgium (MB, MDW); MicroArray Facility, Flanders Interuniversitary Institute for Biotechnology (VIB), Leuven, Belgium (PVH). Correspondence: Ivan...