New Butyroside D from Argan Press Cake Possess Anti-Melanogenesis Effect via MITF Downregulation in B16F10 and HEM Cells

• Published in: International journal of molecular sciences Vol. 23; no. 24; p. 16021
• Main Authors: Bouhoute, Meryem, Amen, Yhiya, Bejaoui, Meriem, Mizushima, Aprill Kee Oliva, Shimizu, Kuniyoshi, Isoda, Hiroko
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.12.2022; MDPI
• Subjects: Acids; Adenosine monophosphate; alpha-MSH - metabolism; alpha-MSH - pharmacology; Animals; Autophagy; Biosynthesis; Butyroside D; c-Kit protein; cAMP; Cell activation; Cell Line, Tumor; Cyclic AMP; Cyclic AMP - metabolism; Cytotoxicity; Down-Regulation; Enzymes; Gene expression; Homeostasis; Humans; Hyperpigmentation; Hyperpigmentation - metabolism; Impact analysis; Inflammation; Inhibition (psychology); Investigations; MAP kinase; MAPK; Melanin; Melanins - metabolism; Melanocortin; Melanocyte-stimulating hormone; Melanocytes; Melanocytes - metabolism; Mice; Microphthalmia-associated transcription factor; Microphthalmia-Associated Transcription Factor - genetics; Microphthalmia-Associated Transcription Factor - metabolism; MITF; Monophenol Monooxygenase - genetics; Monophenol Monooxygenase - metabolism; Protein-tyrosine kinase receptors; Proteins; Tyrosinase; Tyrosine; Ultraviolet radiation; Wnt; Wnt protein; β-Catenin; hyperpigmentation; MITF; MAPK; Wnt; cAMP; Butyroside D

Hyperpigmentation is a skin condition where patches of skin become darker in color due to excess melanin production upon UV exposure leading to melasma, which are lentigines or post inflammatory hyperpigmentation that psychologically affecting a great number of people. The present study investigates...