Canagliflozin Suppresses Atrial Remodeling in a Canine Atrial Fibrillation Model

• Published in: Journal of the American Heart Association Vol. 10; no. 2; p. e017483
• Main Authors: Nishinarita, Ryo, Niwano, Shinichi, Niwano, Hiroe, Nakamura, Hironori, Saito, Daiki, Sato, Tetsuro, Matsuura, Gen, Arakawa, Yuki, Kobayashi, Shuhei, Shirakawa, Yuki, Horiguchi, Ai, Ishizue, Naruya, Igarashi, Tazuru, Yoshizawa, Tomoharu, Oikawa, Jun, Hara, Yoshinobu, Katsumura, Takafumi, Kishihara, Jun, Satoh, Akira, Fukaya, Hidehira, Sakagami, Hiroyuki, Ako, Junya
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 19.01.2021; Wiley
• Subjects: atrial fibrillation; atrial remodeling; canagliflozin; Original Research; oxidative stress; sodium–glucose cotransporter 2 inhibitor; atrial remodeling; sodium–glucose cotransporter 2 inhibitor; atrial fibrillation; oxidative stress; canagliflozin

Background Recent clinical trials have demonstrated the possible pleiotropic effects of SGLT2 (sodium-glucose cotransporter 2) inhibitors in clinical cardiovascular diseases. Atrial electrical and structural remodeling is important as an atrial fibrillation (AF) substrate. Methods and Results The pr...