Geraniin Protects High-Fat Diet-Induced Oxidative Stress in Sprague Dawley Rats
Geraniin, a hydrolysable polyphenol derived from L. fruit rind, has been shown to possess significant antioxidant activity and recently been recognized for its therapeutic potential in metabolic syndrome. This study investigated its antioxidative strength and protective effects on organs in high-fat...
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Published in | Frontiers in nutrition (Lausanne) Vol. 5; p. 17 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
16.03.2018
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Subjects | |
Online Access | Get full text |
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Summary: | Geraniin, a hydrolysable polyphenol derived from
L. fruit rind, has been shown to possess significant antioxidant activity
and recently been recognized for its therapeutic potential in metabolic syndrome. This study investigated its antioxidative strength and protective effects on organs in high-fat diet (HFD)-induced rodents. Rats were fed HFD for 6 weeks to induce obesity, followed by 10 and 50 mg/kg of geraniin supplementation for 4 weeks to assess its protective potential. The control groups were maintained on standard rat chows and HFD for the same period. At the 10th week, oxidative status was assessed and the pancreas, liver, heart and aorta, kidney, and brain of the Sprague Dawley rats were harvested and subjected to pathological studies. HFD rats demonstrated changes in redox balance; increased protein carbonyl content, decreased levels of superoxide dismutase, glutathione peroxidase, and glutathione reductase with a reduction in the non-enzymatic antioxidant mechanisms and total antioxidant capacity, indicating a higher oxidative stress (OS) index. In addition, HFD rats demonstrated significant diet-induced changes particularly in the pancreas. Four-week oral geraniin supplementation, restored the OS observed in the HFD rats. It was able to restore OS biomarkers, serum antioxidants, and the glutathione redox balance (reduced glutathione/oxidized glutathione ratio) to levels comparable with that of the control group, particularly at dosage of 50 mg geraniin. Geraniin was not toxic to the HFD rats but exhibited protection against glucotoxicity and lipotoxicity particularly in the pancreas of the obese rodents. It is suggested that geraniin has the pharmaceutical potential to be developed as a supplement to primary drugs in the treatment of obesity and its pathophysiological sequels. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Specialty section: This article was submitted to Food Chemistry, a section of the journal Frontiers in Nutrition Edited by: Emmanouil Apostolidis, Framingham State University, United States Reviewed by: Suowen Xu, University of Rochester, United States; Hock Eng Khoo, Universiti Putra Malaysia, Malaysia; Viduranga Y. Waisundara, Rajarata University of Sri Lanka, Sri Lanka |
ISSN: | 2296-861X 2296-861X |
DOI: | 10.3389/fnut.2018.00017 |