Amyloid fibril formation is suppressed in microgravity

• Published in: Biochemistry and biophysics reports Vol. 25; p. 100875
• Main Authors: Matsushita, Hiroaki, Isoguchi, Aito, Okada, Masamitsu, Masuda, Teruaki, Misumi, Yohei, Ichiki, Yuko, Ueda, Mitsuharu, Ando, Yukio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2021; Elsevier
• Subjects: Amyloid fibrils; Amyloidosis; Aβ42; Insulin; Microgravity; TTR; PBS; Aβ; ThT; TTR; Aβ42; FSB; DMSO; TTRwt; Amyloid fibrils; Amyloidosis; Insulin; Microgravity; TTRwt, wild-type transthyretin; TTR, transthyretin; PBS, phosphate-buffered saline; Aβ, amyloid β; DMSO, dimethyl sulfoxide; ThT, thioflavin T; FSB, 1-fluoro-2,5-bis[(E)-3-carboxy-4-hydroxystyryl]benzene

In the future, humans may live in space because of global pollution and weather fluctuations. In microgravity, convection does not occur, which may change the amyloidogenicity of proteins. However, the effect of gravity on amyloid fibril formation is unclear and remains to be elucidated. Here, we an...