Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 27; pp. 11008 - 11013
• Main Authors: Wang, Caihong, Mendonsa, Graziella R, Symington, Jane W, Zhang, Qunyuan, Cadwell, Ken, Virgin, Herbert W, Mysorekar, Indira U
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 03.07.2012; National Acad Sciences
• Subjects: Acute Disease; Animal models; Animals; Autophagy; Autophagy - immunology; Bacteria; Bacteriuria; Bacteriuria - immunology; Bacteriuria - pathology; biofilm; Biofilms; Biological Sciences; Bone marrow; Bone Marrow Transplantation; Carrier Proteins - genetics; Carrier Proteins - immunology; Cell Division - immunology; Cells; chimerism; Cytokines; Disease Models, Animal; E coli; Epithelial cells; Escherichia coli Infections - immunology; Escherichia coli Infections - pathology; etiology; Female; Gene expression; genes; hematopoietic stem cells; Homeodomain Proteins - genetics; Humans; Infections; intestines; lysosomes; Mice; Mice, Mutant Strains; monocytes; Monocytes - immunology; mutation; Neutrophils; Neutrophils - immunology; Proteins; Rodents; Transplantation Chimera; Urinary bladder; Urinary Bladder - immunology; Urinary Bladder - microbiology; Urinary Bladder - pathology; urinary tract diseases; Urinary tract infections; Urinary Tract Infections - immunology; Urinary Tract Infections - pathology; Urine; uropathogenic Escherichia coli; Uropathogenic Escherichia coli - immunology; women

Urinary tract infection (UTI), a frequent and important disease in humans, is primarily caused by uropathogenic Escherichia coli (UPEC). UPEC forms acute cytoplasmic biofilms within superficial urothelial cells and can persist by establishing membrane-enclosed latent reservoirs to seed recurrent UTI...